Topics

Emmanuel Nkuwi, George P. Judicate, Toong Seng Tan, Godfrey Barabona, Mako Toyoda, Bruno Sunguya, Doreen Kamori, Takamasa Ueno.

Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity

Journal of Virology

DOI: 10.1128/jvi.00823-23

Terumasa Ikeda#, Ryo Shimizu#, Hesham Nasser, Michael A. Carpenter, Adam Z. Cheng, William L. Brown, Daniel Saute, Reuben S. Harris

APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1

mBio 14, e0078223 (2023)

#contributed equally.

Chihiro Motozono (First & Co-corresponding author), Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Yoshihiko Goto, Yoshiki Aritsu, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Seiji Okada, Keiko Udaka, Mizuki Kitamatsu, Hiroyuki Kishi & Takamasa Ueno (Co-corresponding author) The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition. Nature Communications, 13(1):5440, 2022

Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*co-corresponding authors) SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. Cell Host and Microbe 29(7):1124-1136, 2021

Benjy J.Y. Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono, Yorifumi Satou. HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma. Journal of Clinical Investigation, 2021;131(24):e150472.

Akahoshi, T., Gatanaga, H., Kuse,N., Chikata, T., Koyanagi, M., Ishizuka, N.,
Brumme, C. J., Murakoshi, H., Brumme, Z. L., Oka, S., and Takiguchi, M., T-cell
responses to sequentially emerging viral escape mutants shape long-term HIV-1
population dynamics, PLoS Pathog. e1009177, 2020

Hiroo Katsuya, Saiful Islam, Benjy Jek Yang Tan, Jumpei Ito, Paola Miyazato, Misaki Matsuo, Yuki Inada, Saori C. Iwase, Yoshikazu Uchiyama, Hiroyuki Hata, Tomoo Sato, NaokoYagishita, Natsumi Araya, Takaharu Ueno, Kisato Nosaka, Masahito Tokunaga, Makoto Yamagishi, Toshiki Watanabe, Kaoru Uchimaru, Jun-ichi Fujisawa, Atae Utsunomiya, Yoshihisa Yamano, Yorifumi Satou, The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach, Cell Reports, 724-735.e4, 2019

Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Anna Lissina, Takuya Yamamoto, Victor Appay, and Masafumi Takiguchi, Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells. EBioMedicine. 42:109-119, 2019

Rokeya Siddiqui, Shinya Suzu, Mikinori Ueno, Hesham Nasser, Ryota Koba, Farzana Bhuyan, Osamu Noyori, Sofiane Hamidi, Guojun Sheng, Mariko Yasuda-Inoue, Takayuki Hishiki, Sayaka Sukegawa, Eri Miyagi, Klaus Strebel, Shuzo Matsushita, Kunitada Shimotohno, Yasuo Ariumi, Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages, PLoS Pathog. 14(11): e1007372, 2018

Takayuki Chikata*, Hayato Murakoshi,* Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi　(*Equal contribution), Control of HIV-1 by an HLA-B*52:01-C*12:02 protective haplotype, J. Infect. Dis. 216:1415-1424, 2017

Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi, HIV-1 control by NK cells via reduced interaction between KIR2DL2 and HLA-C*12:02/C*14:03, Cell Reports 17:2210-2220, 2016

Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol. 89:5330-5339, 2015

Takayuki Chikata, Jonathan M. Carlson, Yoshiko Tamura, Mohamed Ali Borghan, Takuya Naruto, Masao Hashimoto, Hayato Murakoshi, Anh Q. Le, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, Zabrina L. Brumme, and Masafumi Takiguchi, Host-specific adaptation of HIV-1 subtype B in the Japanese population, J.Virol. 88:4764-4775, 2014

Kristin Ladell*, Masao Hashimoto*, Maria Candela Iglesias*, Pascal G. Wilmann*, James E. McLaren, Stephanie Gras, Takayuki Chikata, Nozomi Kuse, Solene Fastenackels, Emma Gostick, John S.
Bridgeman, Vanessa Venturi, Zaina Ait Arkoub, Henri Agut, David J.van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi**, Jamie Rossjohn**, David A.
Price** and Victor Appay** (*,** Equal contribution), A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38:425-436, 2013

Takeshi Nishijima, Hirokazu Komatsu, Koichiro Higasa, Misao Takano, Kiyoto Tsuchiya, Tsunefusa Hayashida,Shinichi Oka, and Hiroyuki Gatanaga, Single Nucleotide Polymorphisms in ABCC2 Associate With Tenofovir-Induced Kidney Tubular Dysfunction in Japanese Patients With HIV-1 Infection: A Pharmacogenetic Study, Clin Infect Dis. 55(11):1558-67, 2012

Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung’u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi*, and Philip Goulder* (*equally contribution) Adaptation of HIV-1 to Human Leukocyte Antigen class I . Nature 458: 641-645, 2009

Atsuko Hachiya, Eiichi N. Kodama, Stefan G. Sarafianos, Matthew M. Schuckmann, Yasuko Sakagami, Masao Matsuoka, Masafumi Takiguchi, Hiroyuki Gatanaga, Shinichi Oka. Amino Acid Mutation N348I in the Connection Subdomain of HIV-1 Reverse Transcriptase Confers Multi-class Resistance to Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitors. J. Virol. 82:3261-3270, 2008

Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka and Masafumi Takiguchi, Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs J. Immunol. 178: 5513-5523, 2007

Hiroshi Takata and Masafumi Takiguchi, Three memory subsets of human CD8+ T cells differently expressing 3 cytolytic effector molecules. J Immunol. 177: 4330-4340, 2006

Shinya Suzu, Hideki Harada, Takahiro Matsumoto, and Seiji Okada, HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities, Blood, 105: 3230 – 3237, 2005

Hiroshi Takata, Hiroko Tomiyama, Mamoru Fujiwara, Naoki Kobayashi, and Masafumi Takiguchi, Cutting edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells.　J Immunol. 173(4):2231-2235, 2004

Atsushi Koito, Yuichi Kameyama, Cecilia Cheng-Mayer, and Shuzo Matsushita , Susceptibility of mink (Mustera vision)-derived cells to replication by human immunodeficiency virus type 1, J. Virol. 77, 5109-5117, 2003

Takamasa Ueno, Hiroko Tomiyama, Masafumi Takiguchi, Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA calss I molecules. J.Immunol. 169:4961-4969. 2002