2017

Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayashi H, Danish M, Aoki M, Shiotsu C, Kawamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H.
Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice.
Antiviral Res, in press



Hassan WA, Takebayashi SI, Abdalla MOA, Fujino K, Kudoh S, Motooka Y, Sato Y, Naito Y, Higaki K, Wakimoto J, Okada S, Nakao M, Ishikawa Y, Ito T.
Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung carcinoma.
Lab Invest, in press



Goto H, Kariya R, Kudo E, Okuno Y, Ueda K, Katano H, Okada S.
Restoring PU.1 induces apoptosis amd modulates viral transactibation via interferon-stimulated genes in primary effusion lymphoma.
Oncogene, in press



Kojima Y, Hayakawa F, Morishita T, Sugimono K, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.
YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion Lymphoma.
Pharmacol Res, in press



Dana P, Kariya R, Vaeteewoottacharn K, Sawanyawisuth K, Seubwai W, Matsuda K, Okada S, Wongkham S.
Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the epithelial -to-Mesenchymal Transitional Process.
Oncol Res, in press



Dana P, Vaeteewoottacharn K, Kariya R, Matsuda K, Wongkham S, Okada S.
Repurposing cimetidine for cholangiocarcinoma:antitumor effects in vitro and in vivo.
Oncol lett, 13(3):1432-1436.2017


 2016
 
Koizumi Y, Uehira T, Ota Y, Ogawa Y, Yajima K, Tanuma J, Yotsumoto Y, Hagiwara S, Ikegaya S, Watanabe D, Minamiguchi H, Hodohara K, Mikamo H, Wada H, Ajisawa A, Shirasaka T, Nagai H, Kodama Y, Hisihima T, Mochizuki M, Katano H, Okada S.
Clinical and pathological aspests of human immunodeficiency virus-associated plasmablastic lymphoma - Analysis of 24 cased in Japan -
Int J Hematol, 104(6):669-681, 2016




Alam MM,Kariya R, Kawaguchi A,Matsuda K, Kudo E, Okada S.
Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic retivulum stress..
Apoptosis
, 21(10):1191-1201.2016



Uthaisar K, Vaeteewoottacharn K, Seubwai W, Talabnin C, Sawanyawisuth K, Obchoei S, Kraiklang R, Okada S, Wongkham S.
Establishment and characterization of a novel human cholangiocarcinoma cell line with high metastatic activity.
Oncol Rep
, 36(3):1435-1446.2016




Tsukamoto T, Yamamoto Y, Okada S, and Matano T.
Recursion-based depletion of human immunodeficiency virus-specific naive CD4+ T cells may facilitate persistent viral replication and chronic viraemia leading to acquired immunodeficiency syndrome.
Medical Hypotheses
, 94:81-5.2016



Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno N, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, and Shinkura R.

High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.
Nature Microbiology
,
4;1(9):16103.2016



Itamura H, Shindo T, Tawara I, Kubota Y, kariya R, Okada S, Komanduri KV, and Kimura S.

The MEK inhibitor Trametinib separates murine graft-versus-host diesease from Graft-versus-tumor effects.
JCI Insight
,
7;1(10):e86331. 2016



Kojima Y, Iwasaki N, Yanaga Y, Tanuma J, Koizumi Y, Uehira T, Yotsumoto M, Ajisawa A, Hagiwara S, Okada S, and Nagai H.

End of life care for human immunodeficiency virus-infected patients with malignancies: a questionnaire-based survey.
Palliative Med
,
30(9):869-76. 2016



Seubwai W, Vaeteewoottacharn K, Kraiklang R, Umezawa K, Okada S, and Wongkham S.

Inhibition of NF kB activity enhances sensitivity to anticancer drug in cholangiocarcinoma cells.
Oncology Res
,
23(1):21-28. 2016



Ueda N, Zhang R, Tatsumi M, Liu T-Y, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, and Uemura Y.

BCR -ABL-specific CD4+ T helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells.
Cell Mol Immunol
,
3(6):668-677. 2016



Suico MA, Taura M, Kudo E, Shuto T, Okada S, and
H Kai.

The ETS factor Myeloid Elf-1-like Factor(MEF/Elf4) is transcriptionally and functionally activated by hypoxia.
Biol Pharm Bull
,
39(4):641-647. 2016



Goto H, Kariya R, Matsuda K, Kudo E, Katatno H, Okada S.

A potential role of the NOD genetic background in mouse peritoneal macrophages for the development of primary effusion lymphoma.
Leuk Res
,
42(1):37-42. 2016



Vaeteewoottacharn K, Kariya R, Dana P, Fujikawa S, Matsuda K, Ohkuma K. Kudo R, Kraiklang R, Wongkham C, Wongkham S, and Okada S.

Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma. Tumor Biol, 37(7):9023-9035. 2016



Hattori S, Matsuda K, Kariya R, Harada H, and Okada S.

Expansion of functional human Natural Killer cells with anti-HIV-1 activity in NOD/SCID/Jak3null mice.
Microbiol Immunol
,
60(2):106-113. 2016

 
2015
 
Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y.Nakano K, Ishida T, Okada S, and Watanabe T.
Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma.
Sci Rep , 7(5):17868. 2015



Kojima A, Gotoh K, Shimamoto M, Hasegawa K, and Okada S.

Iodine-131 imaging using 284 keV photons with a small animal CZT-SPECT system dedicated to low-medium-energy photon detection.
Ann Nucl Med , 30(2):169-175. 2016



Hiyoshi M, Okuma K, Tateyama S, Takizawa K, Saito M, Kuramitsu M, Araki K, Morishita K, Okada S, Yamamoto N, Biragyn A, Yamaguchi K, and Hamaguchi I.
Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo.
Retroviology , 12:73. 2015



Nakamura D, Yoshimitsu M, Kuroki A, Hachiman M, Kamada Y, Ezinnne CC, Arai A, Inoue H, Hamada H, Hayashida M, Suzuki S, Fujino S, Arima N, Arima M, Tabuchi T, Okada S, Arima N.
A new ATL xenograft model and evaluation of
pyrrolidine dithiocarbamate as potential ATL therapeutic agent.
Exp Hematol , 43(11):944-950. 2015



Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, and Seya T. PolyI:C-induced, TLR3/RIP3-dependent necroptosis backs up immune effector-mediated tumor elimination in vivo.
Cancer Immunol Res , 3(8):902-914. 2015



Ohkuma K, Matsuda K, Kariya R, Gotoh H,
Kamei S, Hamamoto T, and Okada S.
Anti-inflammatory effects of activated protein C on human dendritic cells.
Microbiol Immunol ,
59(7):381-388. 2015



Okuma Y, Tanuma J, Kamiryo H, Kojima Y, Yotsumoto Y, Ajisawa A, Uehira T, Nagai H, Takeda Y, Setoguchi Y , and Okada S.
A multi-institutional study of clinicopathological features and molecular epidemiology of epidermal growth factor receptor mutations in lung cancer patients living with human immunodeficiency virus infection.
J Cancer Res Clin Oncol , 141(9):1669-1678. 2015



Terahara K, Ishige M, Ikeno S, Okada S, Kobayashi-ishihara M, Ato M, and Tsunetsugu-Yokota Y.
Humanized mice dually challenged with R5 and X4 HIV-1 show preferential R5 viremia and restricted X4 infection of CCR5+CD4+ T cells.
Microbes Infect, 17(5):378-386. 2015



Motoyama K, Onodera R, Tanaka N, Kameyama K, Higashi T, Kariya R, Okada S, and Arima H.
Evaluation of antitumor Effect of Folate-conjugated Methyl-β-cyclodextrin for melanoma.
Chem Pharm Bull, 38(3):374-379. 2015



Matsuda K, Hattori S, Kariya R, Komizu Y, Kudo R, Goto H, Taura M, Ueoka R, Kimura S, and Okada S
Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity.
Biochem Biophys Res Comm, 475:288-294. 2015



Taura M, Kudo E, Kariya R, Goto H, Matsuda K, Hattori S, Vaeteewoottacharn K, McDonald F, Suico MA, Shuto T, Kai H, and Okada S.
COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization .J Virol .89(5):2643-2658. 2015


 2014
 
Sueoka-Aragane N, Sato A, Kobayashi N, Ide M, Yokoo M,Nagano Y, Sueoka E, Okada S, and Kimura S.
Correlation between plasma DNA and tumor status in an animal mode.PloS One, 9(12):e111881. 2014



Gotoh K, Kariya R, Alam MM, Matsuda K, Hattori S, Maeda Y, Motoyama K,Kojima A, Arima H, and Okada S
The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts.
Biochem Biophys Res Comm,
455(3-4):285-289. 2014



Kariya R, Matsuda K, Gotoh K, Vaeteewoottacharn K,Hattori S, and Okada S
Establishment of Nude Mice with Complete Loss of Lymphocytes and NK Cells and Application for In Vivo Bio-imaging.In Vivo, 28(5):779-784. 2014



Gotoh K, Kariya R, Matsuda K, Hattori S,Vaeteewoottacharn K, and Okada S.
A novel EGFP-expressing nude mice with complete loss of lymphocytes and NK cells to study tumor-host interanctions.Bio Science Trends. 8(4):202-205. 2014



Vaeteewoottacharn K, Seubwai W, Bhudhisawasdi V,Okada S, Wongkham S.
Potential targeted therapy for liver fluke associated cholangiocarcinoma.J Hepatobilliary Pancreat Sci.21(6):362-370. 2014



Matsuda K, Hattori S
, Komizu Y, Kariya R, Ueoka R and Okada S

Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity
Bioorg Med Chem Lett, 1:24(9):2115-7. 2014



Goto H, Kojima Y, Matsuda K, Kariya R, Taura M, Kuwahara K, Nagai H, Katano H and Okada S
Efficacy of anti-CD47 antibody-mediated phagocytosis with macrophages against primary effusion lymphoma.
Eur J Cancer, 50(10):1836-46. 2014.



Kariya R, Taura M, Suzu S, Kai H, Katano H, Okada S.
HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.
CancerLetters, 1;342(2):52-9,2014



Suwannalert P, Kariya R, Suzu Iand Okada S
The effects of Salacia reticulate on anti-cellular oxidants and melanogenesisi inhibition in α-MSH-stimulated and UV irradiated B16 melanoma cells .
Natural Product Communications 9(4):551-554 2014


 2013
 
Puthdee N, Vaeteewoottacharn K, Seubwai W,Wonkchchalee O, Kaewkong W, J Uasook A, Pinlaor S, Pairojkul C, Okada S, Boonmars T, Wongkham S.
Establishment of an allo-transplantable hamster cholangiocarcinoma cell line and its application for in vivo screening of ant-cancer drugs.Korean J.Parasitol 51(6):711-7. 2013



Taura M, Kariya R, Kudo E, Goto H, Iwawaki T.Amano M, Suico MA, Kai H,Mitsuya H, Okada S.
Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway.
Free Radic Biol Med .65:778-88 2013



Vaeteewoottacharn K, Mitchai M, Srikoon P, Hattori S, Kariya R, Matsuda K Wongkuham S, Okada S.
Potent reative oxygen species JNK-p38 activation by sodium salicylate potentiates death of primary effusion lymphoma cells.
Anticancer Res, 34(4):1865-71, 2013



Srikoon P, Kariya R, Kudo E, Goto H, Vaeteewoottacharn K, Taura M,Wongkham S, Okada S
Diethyldithiocarbamate suppress NF-κB dependent matastatic pathway in cholangiocarcinoma cell line.
Asian Pacific Journal of Cancer Prevention, 14(7);4441-6, 2013



Vaeteewoottacharn K, Kariya R, Matsuda K, Taura M, Wongkham C, Wongkham S, Okada S.
Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.
J. Cancer Res. Clin Oncol, 139(9);1551-62, 2013




Goto H, Kojima Y, Nagai H, and Okada S.
Establishment of a CD4-positive cell line from an AIDS-related primary effusion lymphoma.
Int J Hematol. 97(5)623-33, 2013



Onodera R, Motoyama K, Okamatsu A, Higashi T, Kariya R, Okada S, and Arima H.
Involvementof cholesterol depletion from lipid rafits in apoptosis induced by methyl-β-cyclodextrin.
Int J Pharm 452(1-2):116-23,2013



Ohsugi T,m Ishida T, Shimasaki T, Okada S, and Umezawa K.
p53dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressin Tax, a human T-cell leukemia virus type 1 oncoprotein.
Carcinogenesis Sep;34(9):2129-36 2013



Nakamura T, Aizawa T, Kariya R, Okada S, Demura M, Kawano K, Makabe K, and Kuwajima K.
Molecular mechanisms of the cytotoxicity of HAMLET and other protein-oleic acid complexes.
J Biol Chem 288(20):14408-14416,2013



Suzu I, Goto H, Hiwatashi N, Hattori S, Rotjanapan K, Leeanansaksiri W, and Okada S.
Antioxidant an Antityrosinase Activity of Cissus quadrangularis Extract.
Nat ProdCommun 8(5):629-630, 2013



Tanaka A, Takeda S, Kariya R, Matsuda K, Urano E, Okada S, and Komano J.
A novel therapeutic molecule against HTLV-1 infection targeting provirus.
Leukemia Aug.27(8):1621-72013



Goto H, Matsuda K, Srikoon P, Kariya R, Hattori S, Taura M, Katano H, and Okada S.
Protein antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma.
CancerLett 1;331(2):174-82.2013



Kudo E, Taura M, Matsuda K, Shimamoto M, Kariya RGoto H, Hattori S, Kimura S, and Okada S.
Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in actuely and chronically infected cells.
Bioorg Med Chem Lett 23(1):606-609, 2013



Tsuruoka N, Arima M, Okada S, Sakamoto A, Hatano M, Arguni E, O-Wang J, Jing-Hua Y, Sekiya S, Shozu M, and Tokuhisa T.
ADAR1 induces adenosine-targeted DNA mutations in senescent Bcl6-deficient cells.
J Bio Chem 288(2):826-836, 2013



Terahara K, Ishige M, Ikeno S, Mitsuki Y, Okada S, Kobayashi K, and Tsunetsugu-Yokota Y.
Evaluation of a Humanized NOD/SCID/JAK3null Mouse Model: Expansion of CD4+ T cells with an Activated Memory Phenotype Affects Infectivity of CCR5-Tropic HIV-1 in vivo.
PLoS ONE 8(1):e53495, 2013



Yuki H, Ueno S, Tatetsu H, Kawano Y, Niiro H, Ino T, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H, and OkunoY.
PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells.
Blood 7;121(6):962-70,2013



Uthaisar K, Sebwai W, Srikoon P, Vaeteewoottacharn K, Sawanyawisuth K, Okada S, and Wongkham S.
Cepharanthine supresses metastatic potential of human cholangiocarcinoma cell lines.
Asian Pac J Cancer Prev 13(KKSuppl):149-154, 2012


Komizu Y, Yukihira M, Ichihara H, Matsumoto Y, Okada S, and Ueoka R.
Therapeutic effects of hybrid liposomes for mouse model of adult T-cell leukemia/lympgoma in vivo.
Nano Bulletin 1(1):120105, 2012



Hagiwara S, Yotsumoto M, Odawara T, Ajisawa A, Uehara T, Nagai H, Tanuma J, and Okada S.
Non-AIDS-defining hematological malignancies in HIV-infected patients: an epidemio;ogical study in Japan.
AIDS 27(2):279-283, 2013


 2012
 
Mitchai M, Goto H, Hattori S, Vaeteewoottacharn K, Wongkham C, Wongkham S, and Okada S.
Soluble CD30: a possible serum tumor marker for primary effusion lymphoma.
Asian Pac J Cancer Prev 13(10):4939-4941, 2012



Khaenam P, Niibori A, Okada S, Jearanaikoon P, Araki N, and Limpaiboon T.
Contribution of RIZ1 in proliferation and migration of liver fluke-related cholangiocarcinoma cell line.
Asian Pac J Cancer Prev 13(8):4007-4011, 2012



Yotsumoto M, Hagiwara S, Ajisawa A, Tanuma J, Uehara T, Nagai H, Fujiwara Y, Maedda S, Kitano K, Arima N, Uno K, Iwai T, Hongo I, Ota Y, Fukutake K, Okada S.
Clinical charactaristics of human immunodeficiency virus-associated Hodgkin lymphoma patients in Japan.
Int J Hematol 96(2):247-253, 2012



Mitsuki Y, Terahara K, Shibusawa K, Yamamoto T, Tsuchiya T, Mizukoshi F, Ishige M, Okada S, Kobayashi K, Morikawa Y, Nakayama T, Takeda M, Yanagi Y, and Tsunetsugu-Yokota Y.
HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4+ T cells.
J Virol
86(13):7227-7234, 2012



Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, Okada S, and Kai H.
Rb/E2F1 regulate innate immune receptor Toll-like receptor 3 in epithelial cells.
Mol Cell Biol 32(8):1581-1590, 2012



Chihara T, Hashimoto M, Osman A, Hiyoshi-Yoshidomi Y, Suzu I, Chutiwitoonchai N, Hiyoshi M, Okada S, Suzu S.
HIV-1 Proteins Preferentially Activate Anti-Inflammatory M2-Type Macrophages.
J Immunol 188(8):3620-3627, 2012



Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Matsuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, and Oike Y.
Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis
Cancer Res 72(7):1784-1894, 2012



Tanimoto S, Sakai S, Kudo E, Okada S, Matsunuma S, Takahashi D, and Toshima K.
Target-selective photo-degradation of HIV-1 protease and inhibition of HIV-1 replication in living cells by designed fullerene-sugar hybrids
Chemistry- An Asian Journal 7(5):911-914, 2012



Phimsen S, Kuwahara K, Nakaya T, Ohata K,Suda T, Rezano A, Kitabatake M, Vaeteewoottacharn K, Okada S, Tone S, and Sakaguchi N.
Selective cell death of p53-insufficient cancer cells in induced by knockdowun of the mRNA export molecule GANP.
Apoptosis 17(7):679-90. 2012



Xi Y, Watanabe S, Hino Y, Sakamoto C, Nakatsu Y, Okada S, and Nakao M.
Hmga1 is differentially expressed and mediates transcriptional silencing of the Cd4/Cd8 loci in T cell lineages and leukemic cells.
Cancer Sci 103(3): 439-447. 2012



Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa I, Nagata K, Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M ,and Saya H.
Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.
Oncogene doi:10.1038/onc.2011.462, 2011



Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi Y, Matsuyama S, Okamoto Y, Shuto T, Kai H, and Okada S.
Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway.
Int J Oncol 40(4):1071-1078, 2012



Kasama Y, Satoh M, Saito M, Okada S, Kai C, and K Tsukiyama-Kohara.
Evaluation of a recombinant measles virus as the expresstion vector of hepatitis C virus envelope proteins.
World Vaccines in press


2011

Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H, and Okada S.
The antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway.
Cancer Sci 103(4) 775-781, 2011



Chutiwitoonchai N, Hiyoshi M, Mwinanzi P, Ueno T, Adachi A, Ode H, Sato H, Fackler OT, Okada S, and Suzu S.
The Identification of a Small Molecule Compound that Reduce HIV-1 Nef-mediated Viral Infectivity Enhancement.
ProS. ONE 6(11):e27696, 2011



Komizu Y, Yukihara M, Kariya R, Goto K, Okada S and Ueoka R.
Selective accumulation of hybrid liposomes into adult T-cell lukemia cells along with induction of apoptosis.
Bioorg Med Chem Lett 21(13):3962-3965, 2011



Hiyoshi M, Takahashi-Makise N, Yoshidomi Y, Chutiwitoonchai N, Chihara T, Okada M, Nakamura N, Okada S and Suzu S.
HIV-1 Nef Perturbs the Function, Structure, and Signaling of the Golgi through the Src Kinase Hck.
J Cell Physiol 227(3): 1090-1097, 2011



Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H,
Suzu S, Okada S.
Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice.
J Biomed Biotechnol 2011:539748, 2011




Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M,
Hatano M, Okada S and Tokuhisa T.

Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells.
J Immunol 186(1):255-263, 2011




Taura M, Suico MA, Koga R, Shuto T, Sato T, Morino-Koga S,
Okada S and Kai H.

MEF/ELF4 transactivation by E2F1 is inhibited by p53.
Nucleic Acid Res 39(1):76-88, 2011

 
2010

Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M,
Motoyoshi K, Kimura F, and Okada S.

IL-34 and M-CSF share the receptor Fms but are not indentical in biological activity and signal activation.
Cell Death Differ 17(12) 1917-1927, 2010



Satoh M, Saito M, Tanaka K, Iwanaga S, Nagla S, Seki T, Okada S, Kohara M, Harada S, Kai C, and Tsukiyama-Kohara K.
Evaluation of a recombinant measeles virus expressing hempatitis C virus envelope proteins by infection of human PBMC-NOD/Scid /Jak3null mouse.
Comp Immunol Microbiol Infect Dis 33(6):e81-88, 2010


Seubwai W, Wongkham C, Puapairoj A, Okada S and Wongkham S.
22-oxa-1,25-dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculutre of Cholangiocarcinoma.
Cancer 116(23):5535-5543, 2010



Shimasaki S, Koga T, Shuto T, Suico M A, Sato T, Watanabe K,
Morino-Koga S, Taura M, Okada S, Mori K, and Kai H.

Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells.
Biochem Biophys Res Comm 402(2):235-240, 2010


Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y,
Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E,
Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda S,
Suda T, and Saya H.

c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
Oncogene 29(42):5687-5699, 2010



Subimerb C, Pinlaor S, Lulitanond V, Khuntikeo N, Okada S, McGrath MS,
Wongkham S.

Circulating CD14(+)CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma.
Clin Exp Immunol 161(3):471-479, 2010



Seubwai W, Vaeteewoottacharn K, Hiyoshi M, Suzu S, Puapairoj A,
Wongkham C, Okada S and Wongkham S.

Cepharanthine exerts anti-tumor activity on cholangiocarcinoma by inhibiting NF-κB.
Cancer Sci 101(7):1590-1595, 2010



Towata T, Komizu Y, Suzu S, Ueoka R, and Okada S.
Highly selective fusion and accumulation of hybrid liposomes into Primary Effusion Lymphoma Cells along with induction of apoptosis.
Biochem Biophys Res Comm 393(3):445-448, 2010



Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu S, Sasaki Y, and Okada S.
Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by antiviral treatment.
Biochem Biophys Res Comm 393(2):331-337, 2010



Towata T, Komizu Y, Kariya R, Suzu S, Matsumoto Y, Kobayashi N,
Wongkham C, Wongkham S, Ueoka R, and Okada S.

Hybrid liposomes inhibit the growth of Cholangiocarcinoma by induction of cell cycle arrest in G1 phase.
Bioorg Med Chem Lett 20(12):3680-3682, 2010



Nagai H, Odawara T, Ajimsawa A, Hagiwara S, Watanabe T, Uehira T, Uchiumi H, Yotsumoto M, Miyakawa T, Watanabe A, Kanbe T, Konishi M, Saito S, Takahama S, Tateyama M, and Okada S.
Whole Brain radiation alone produces favorable outcomes for AIDS-related primary central nervous system llymphoma in the HAART era.
Eur J Haematol 84(6):499-505, 2010



Towata T, Komizu Y, Suzu S, Matsumoto Y, Ueoka R, and Okada S.
Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo.
Leukemia Res 34(7):906-911, 2010



Shiraishi Y, Gotoh K, Towata T, Shimasaki T, Suzu S, Kojima A, and Okada S.
Therapeutic effects of γ-irradiation in a primary effusion lymphoma mouse model.
Exp Therap Med 1(1):79-84, 2010


2009

Hattori S, Ide K, Nakata H, Harada H, Suzu S, Ashida N, Kohgo S, Hayakawa H, Mitsuya H, and Okada S.
Potent activity of a Nucleoside Reverse Transcriptase Inhibitor, 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine, against HIV-1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Antimicrob Agents Chemother 53(9):3887-3893,2009


Hassan R, Suzu S,Hiyoshi M,Takahashi-Makise N, Ueno T, Agatsuma T, Akari H, Komano J, Takebe Y, Motoyoshi K, and Okada S.
Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbes N-glycosylation of a cytokine receptor Fms.
J Cell Physiol 221(2):458-468, 2009


Takahashi-Makise N, Suzu S, Hiyoshi M, Ohsugi T, Katano H, Umezawa K, and Okada S.
Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apotosis via suppression of the NK-κB pathway.
Int J Cancer 125(6):1464-1472, 2009



2008

Okada S,Harada H
, Ito T, Saito T, and
Suzu S.
Early development of human hematopoietic and acquired immune systems in NOD/Scid/Jack3null mice intrahepatic engrafted with cord blood-derived CD34+ cells.
Int J Hematol 88(5):476-482, 2008


Murakami T, Harada H, Suico MA, Shuto T, Suzu S, Kai H, and Okada S.
Ephedrae herba, a component of Japanese herbal medicin Mao-to, efficiently activates the replication of latent HIV-1 in a monocytic cell line.
Biol Pharm Bull 31(12):2334-2337, 2008


Wang X, Xiao G, Zhang Y, Gao X, Okada S, and Liu X.
Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition.
Nature Immunol 9(7):794-801, 2008



Nagai H, Iwasaki N, Odawara T, and Okada S.
Actual status of AIDS-related lymphoma management in Japan
Int J Hematol 87(5):442-443, 2008


Hiyoshi M,Suzu S,Yoshidomi Y, Hassan R, Harada H, Sakashita N, Akari H, Motoyoshi K, and Okada S.
Intraction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.
Blood 111(1):52-58, 2008



2007











Harada H, Murakami T, Tea SS, Takeuchi A, Koga T,
Okada S, Suico MA, Shuto T and Kai H

Heat shock suppresses human NK cell cytotoxicity via regulation of perforin.
Int J Hyperthermia 23(8):657-665, 2007




Yamamoto K, Suzu S, Yoshidomi Y, Hiyoshi M, Harada H, Okada S.
Erythroblasts highly express the ABC transporter Bcrp1/ABCG2 but do not show the side population (SP) phenotype.
Immunol Lett. 114(1):52-58,2007



Harada H, Goto Y, Ohno T, Suzu S and Okada S
Proliferative activation up-regulates the expression of CD4 and HIV-1 co-receptors on NK cells and induces HIV-1 infection of NK cells
.
Eur J Immunol.
37(8):2148-2155. 2007.




Suzu S, Hiyoshi M, Yoshidomi Y, Harada H, Takeya M, Kimura F, Motoyoshi K and Okada S
M-CSF-mediated macrophage differentiation but not proliferation is correlated with increased and prolonged ERK activation.
J Cell Physiol. 212(2):519-525. 2007.

2005













Harada H, Suzu S, Ito T and Okada S.
Selective expansion and engraftment of human CD16+ NK cells in NOD/Scid mice.
Eur J Immunol.
35(12):3599-3609. 2005.




Koga T, Harada H, Shi TS, Okada S, Suico MA, Shuto S and Kai H.
Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression.
Biochem Biophys Res Commun. 337(4):1319-1323. 2005.




Harada H
, Suzu S, Hayashi Y and Okada S
.
BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.
J Cell Physiol. 204(3):919-926. 2005.




Suzu S, Harada H, Matsumoto T
, and Okada S
.
HIV-1 Nef interferes with M-CSF receptor signalling through Hck activation and inhibits M-CSF bioactivities.
Blood. 105(8):3230-3237, 2005
.

  2004

Koshizuka S, Okada S, Okawa A, Koda M, Murasawa M, Hashimoto M, Kamada T, Yoshinaga K, Murakami M, Moriya H, and Yamazaki M; Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice.
J Neuropath Exp Neur 63(1):64-72,2004

Kawamura K, O-Wang J, Ogawa R, Bahar R, Seimiya M, Chiyo M, Wada A, Okada S, Hatano M, Tokuhisa T, Kimura H, Watanabe S, Honda I, Sakiyama S, and Tagawa M. DNA polymerase is preferentially expressed in lymphoid tissues and upregulated in human cancers.
Int J Cancer 109(1):9-16,2004

Seimiya M, Wada A, Kawamura K, Sakamoto A, Ohkubo Y, Okada S, Hatano M, Tokuhisa T, Watanabe T, Saisho H, Tagawa M, and O-Wang J; Impaired lymphocyte development and function in Clast5/Stra13/DEC1 transgenic mice.
Eur J Immunol 34(5):1322-32, 2004

Asari S, Okada S, Ohkubo Y, Sakamoto A, Arima M, Hatano M, Kuroda Y, and Tokuhisa T; Beta-galactosidase of ROSA26 mice is a useful marker for detecting the definitive erythropoiesis after stem cell transplantation.
Transplantation 78(4):516-523, 2004