9th AIDS Seminar in KUMAMOTO
■ 18 September

Opening Remarks Masafumi Takiguchi [Director of CAIDS, Kumamoto Univ.]



SessionT
10:30-11:30
Chairpersons: A. Koito[Kumamoto Univ.], Y. Kikuchi[IMCJ]

Kazuhisa Yoshimura [Kumamoto Univ.]
In vitro induction of human immunodeficiency virus type 1 variants resistant to a low-molecular CD4 mimic compound



Shogo Misumi [Kumamoto Univ.]
Tetragalloyl-D-trilysinyldiethylamine (TGDK)-mediated vaccine delivery system represents a potential approach for enabling M-cell-targeted mucosal vaccine in primates




Hiroyuki Gatanaga
[IMCJ]
Impact of polymorphic mutations on the emergence of drug-resistant HIV-1




Session II
11:30-12:45
Chairpersons: S. Okada[Kumamoto Univ.], M. Fujita[Kumamoto Univ.]

Masateru Hiyoshi [Kumamoto Univ.]
Dys-regulated activation of a Src tyrosine kinase Hck at the Golgi apparatus by Nef impairs protein Glycosylation and trafficking



Kenji Ohba [NIID]

Follicular dendritic cells activate HIV-1 replication through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand-1



Masayuki Amano
[Kumamoto Univ.]
Spontaneous degradation of Gag proteins in multi-drug-resistant HIV-1 variants containing insertions in Gag proteins



Hirokazu Koizumi
[Kumamoto Univ.]
Different effects of HIV-1-specific CTLs having a strong ability to suppress HIV-1 replication on selection of escape mutant viruses



Chihiro Motozono
[Kumamoto Univ.]
The decay of peptide-MHC complex influences antiviral activity of HIV-specific CTLs


Young Investigator SessionT
14:00-14:36
Chairpersons: M. Hiyoshi[Kumamoto Univ.], H. Koizumi[Kumamoto Univ.]

Yuzuru Minemoto [IMCJ]
An association between HIV-1 Vpr and Snf2h, a chromatin remodeling factor, facilitates viral integration into pericentromeric heterochromatin



Terumasa Ikeda
[Kumamoto Univ.]
The anti-retroviral potency of APOBEC1 cytidine deaminase from small animal species



Taisuke Izumi [Kyoto Univ.]
HIV-1 Vif Causes G2 Cell Cycle Arrest via the p53 Pathway


Young Investigator Session II
14:36-15:00
Chairpersons:T. Ikeda[Kumamoto Univ.], N. Kuse[Kumamoto Univ.],

Makiko Hatada [Kumamoto Univ.]
The impact of an N-linked glycosylation site insertion in HIV-1 gp120 V2 region to escape from a potent neutralization anti-V3 monoclonal antibody



Manabu Aoki [Kumamoto Univ.]
Role of Gag mutations in HIV in its replication fitness and acquisition of resistance to protease inhibitors




Young Investigator Session III
15:00-15:36

Chairpersons: N. Kobayashi[Kumamoto Univ.], C. Motozono[Kumamoto Univ.]

Takuya Yamamoto
[NIID]
SIV-specific functional T-cell induction after passive neutralizing antibody immunization postinfection



Katsuhisa Inaba
[Kyoto Univ.]
CD4+ cell reduction and enteropathy in small intestine can be occurred irrespective of viral load in simian/human immunodeficiency virus infection.



Nan Zheng
[Kumamoto Univ.]
Killing of HIV-1-infected CD4+ T cells and macrophages by an HIV-1 Nef-specific CD4+ CTL


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