Pathogenesis-I
8:00-9:45
Chairpersons: S. Harada[Kumamoto Univ.], S. Suzu[Kumamoto Univ.]
Tatsuo Shioda [Osaka Univ.]
Viral determinant of TRIM5α sensitivity
Akihide Ryo [NIID]
Identification of host factors required for HIV-1 Gag trafficking
Ranya Hassan [Kumamoto Univ.]
More severe protein maturation interference by HIV-1 Nef and Hck: molecular mechanism
and its restoration by small molecule compound
Gary Thomas [Vollum Institute]
HIV-1 Nef assembles a multi-kinase cascade to downregulate cell-surface MHC-I
Immunology-I
10:00-11:25
Chairpersons: M. Takiguchi[Kumamoto Univ.], T. Kuwata[Kumamoto Univ.]
Tetsuro Matano [Univ. of Tokyo]
Impact of vaccine-induced Gag-specific CTL responses on SIV control
Takamasa Ueno [Kumamoto Univ.]
The balance of power: Nef and CTL
Victor Appay [INSERM]
The nature of CD8+ T cell efficacy in HIV-1 infection
Immunology-II
11:25-12:20
Chairpersons: T. Takiguchi[Kumamoto Univ.], T. Ueno[Kumamoto Univ.]
Hiroshi Takata [Kumamoto Univ.]
Detailed analysis of functionally distinct human effector CD8+ T cell subsets
Rafick-Pierre Sekaly [Universite de Montreal]
Systems Biology approaches to The understanding of memory T cell homeostasis and pathogenesis
Drug/resistance
13:25-14:55
Chairpersons: H. Mitsuya [Kumamoto Univ.], S. Oka [IMCJ]
Kenji Maeda [NCI, NIH]
Structure-guided approach for the development of AIDS therapeutics: Design of CCR5 inhibitors and the study of their interactions with CCR5
Yasuhiro Koh [Kumamoto Univ.]
Non-peptidyl small molecule protease dimerization inhibitors (PDIs): molecular and structural analysis of their HIV-1 inhibition and interactions with protease monomer subunit
Atsuko Hachiya [Kumamoto Univ./IMCJ]
Mutations in the connection and RNase H subdomains of HIV-1 reverse transcriptase in the antiretroviral treatment-naive patients.
Michael A. Parniak [Univ. of Pittsburgh]
HIV ribonuclease H as a target for antiretroviral drug discovery
Pathogenesis-II
15:05-16:30
Chairpersons: S. Matsushita [Kumamoto Univ.], T. Matano T [Univ. of Tokyo]
Jason Brenchley [NIAID, NIH]
Mucosal dysfunction and immune activation in lentiviral infections
Tatsuhiko Igarashi [Kyoto Univ.]
“Work In Progress” toward developing a better non-human primate model for AIDS
Takeo Kuwata [Kumamoto Univ./NIAID, NIH]
Two modes of disease progression in SIV infection: Implication of naive CD4+ T cell depletion and autoantibodies for progressive CD4+ T cell decline
Closing Remarks Hiroaki Mitsuya [Kumamoto Univ.]
