研究成果一覧

   2012  2011  2010   2009   2008

2012


 

Chutiwitoonchai N, Hiyoshi M, Hiyoshi-Yoshidomi Y, Hashimoto M, Tokunaga K, Suzu S, Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins, Microbes and Infection, in press.

  Yagita Y*, Kuse N*, Kuroki K*, Gatanaga H, Carlson JM, Chikata T, Brumme ZL, Murakoshi H, Akahoshi T, Pfeifer N, Mallal S, John M, Ose T, Matsubara H, Kanda R, Fukunaga Y, Honda K, Kawashima Y, Ariumi Y, Oka S,  Maenaka K, and Takiguchi M, (*Equal contribution), Distinct HIV-1 Escape Patterns Selected by CTLs with Identical Epitope Specificity, J. Virol. In press.
  Koito A & Ikeda T, Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Front. Microbiol. In press
  Hagiwara S, Yotsumoto M, Odawara T, Ajisawa A, Uehira T, Nagai H, Tanuma J, and Okada S. Non-AIDS-defining hematological malignancies in HIV-infected patients: an epidemiological study in Japan. AIDS in press
  Maeda Y, Yoshimura K, Kodama E, Miyamoto F, Harada S, Yuan Y, Harada S, and Yusa K, Acquisition of resistance to HIV-1 entry inhibitors in vitro and in vivo. Journal of AIDS and Clinical Research,  in press
  Aoki M, Danish ML, Aoki-Ogata H, Amano M, Ide K, Das D, Koh Y and Mitsuya H, Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1. J. Virol. 86: 13384-13396, 2012
  Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H, Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. Bioorg Med Chem Lett. 22: 2308-11, 2012
  Ghosh AK, Anderson DD, Weber IT, Mitsuya H, Enhancing protein backbone binding: a fruitful concept for combating drug-resistant HIV. Angew Chem Int Ed Engl. 51(8): 1778-802, 2012
  Sato Y, Nagata S, and Takiguchi M, Effective elicitation of human effector CD8+ T cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1,  PLoS ONE 7: e42776, 2012
  Matthews PC*, Koyanagi M*, Kløverpris HN*, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Molina CJ, Ponce HV, Rios SA, Cole D, Carlson J, Payne RP, Ogwu A, Bere A, Ndung’u T, Gounder T, Chen F, Riddell L, Luzzi G, Shapiro R, Brander C, Walker B, Sewell A, Teran GR, Heckerman D, Hunter E, Buus S, Takiguchi M, and Goulder PJR (*Equal contribution), Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope,  J. Viro. 86: 12643-12654, 2012
  Yotsumoto M, Hagiwara S, Ajisawa A, Tanuma J, Uehira T, Nagai H, Fujikawa Y, Maeda S, Kitano K, Arima N, Uno K, Iwai T, Hongo I, Ota Y, Fukutake K, Okada S. Clinical characteristics of human immunodeficiency virus-associated Hodgkin lymphoma patients in Japan. Int J Hematol 96(2):247-253, 2012
  Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H, and Okada S. The antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway. Cancer Sci 103(4):775-781, 2012
  Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi Y, Matsuyama S, Okamoto Y, Shuto T, Kai H, and Okada S. Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway. Int J Oncol 40(4):1071-1078, 2012
  Nishijima T, Komastu H, Higasa K, Takano M, Tsuchiya K, Hayashida T, Oka S, and Gatanaga H. Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: A pharmacogenetic study. Clin Infect Dis 55 (11): 1558-1567, 2012.
  Nishijima T, Yazaki H, Hinoshita F, Tasato D, Hoshimoto K, Teruya K, Gatanaga H, Kikuchi Y, and Oka S. Drug-induced acute interstitial nephritis mimicking acute tubular necrosis after initiation of tenofovir-containing antiretroviral therapy in patient with HIV-1 infection. Intern Med (Case report) 51(17): 2469-2471, 2012.
  Yashiro S, Fujino Y, Tachikawa N, Inamochi K, Oka S. Long-term control of CMV retinitis in a patient with idiopathic CD4(+) T lymphocytopenia. J Infect Chemother 2012 Aug 31. [Epub ahead of print]
  Nishijima T, Teruya K, Yanase M, Tamori Y, Mezaki K, and Oka S. Infectious endocarditid caused by Lactobacillus acidophilus in a patient with mistreated dental caries. Intern Med 51: 1619-1621, 2012.
  Nishijima T, Teruya K, Komatsu H, Tsukada K, Gatanaga H, Kikuchi Y, and Oka S. Efficacy and safety of once-daily abacavir/lamivudine versus tenofovir/emtricitabine with ritonavir-boosted darunavir for treatment-naïve patients with baseline HIV-1 viral load >100,000 copies/mL. AIDS (Research Letter) 24: e32835, 2012.
  Kinai E, Hosokawa S, Gomibuchi H, Gatanaga H, Kikuchi Y, Oka S. Blunted fetal growth by tenofovir in late pregnancy. AIDS (correspondence) 2012 Vol. 26 (2119-2120)
  Mwimanzi P, Markle TJ, Ueno T, Brockman MR, HLA class I down-regulation by HIV-1 Nef: What might we learn from natural sequence variants? Viruses 4:1844-2416, 2012
 

Hashimoto M, Akahoshi T, Murakoshi H, Ishizuka N, Oka S, and Takiguchi M, CTL recognition of HIV-1-infected cells via cross-recognition of multiple overlapping peptides from a single 11-mer Pol sequence. Eur. J. Immunol. 42:2621-2631,2012

  Naruto T, Gatanaga H, Nelson G, Sakai K, Carrington M, Oka S, and Takiguchi M, HLA class I mediated control of HIV-1 in Japanese, where the protective HLA-B*57 and -B*27 are absent. J. Virol, 86:10870-10872, 2012
 

Hamada Y, Nishijima T, Watanabe K, Komatsu H, Tsukada K, Teruya K, Gatanaga H, Kikuchi Y, and Oka S. High incidence of renal stones in HIV-infected patients on ritonavir-boosted atazanavir- than in those on other protease inhibitors-containing antiretroviral therapy. Clin Infect Dis,  55 (9): 1262-1269, 2012

 

Toda T, Kuwahara K, Kondo N, Matsuda Z, Maeda Y, Maeda K, and Sakaguchi N. Dynamic appearance of antigenic epitopes effective for viral neutralization during membrane fusion initiated by interactions between HIV-1 envelope proteins and CD4/CXCR4. Immunobiology,  217, 864-872, 2012

  Maeda, K., Das, D. Nakata, H., and Mitsuya, H. CCR5 inhibitors: emergence, success, and challenges. Expert Opinion on Emerging Drugs. 17:135-45, 2012
 

Koito A, and Ikeda T. Apolipoprotein B mRNA-editing, catalytic polypeptide cytidine deaminases and retroviral restriction. Wiley Interdisciplinary Reviews (WIREs) RNA. 3(4): 529-541, 2012.

 

Hasan Z, Carlson JM, Gatanaga H, Le AQ, Brumme CJ, Oka S, Brumme ZL, and Ueno T, Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu. Biochem. Biophys. Res. Comm. 421: 291-295, 2012

 

Chihara T, Hashimoto M, Osman MA, Hiyoshi-Yoshidomi Y, Suzu I, Chutiwitoonchai N, Hiyoshi M, Okada S, and Suzu S, HIV-1 Proteins Preferentially Activate Anti-inflammatory M2-type Macrophages. J Immunol, 188: 3620-3627, 2012

 

Hiyoshi M, Takahashi-Makise N, Yoshidomi Y, Chutiwitoonchai N, Chihara T, Okada M, Nakamura N, Okada S, and Suzu S. HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src kinase Hck. J Cell Physiol, 227: 1090-1097, 2012

 

Takano M, Okada M, Oka S, and Wagastuma Y, The relationship between HIV testing and CD4 counts at HIV diagnosis among newly diagnosed HIV-1 patients in Japan. Int J STD AIDS, 23:262-266, 2012

  Akahoshi T,  Chikata T, Tamura Y, Gatanaga H, Oka S, and Takiguchi M, Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific CTLs recognizing wild-type and/or escape mutant epitopes. J. Virol. 86:1971-1981,2012.
 

Nishijima T, Tsukada K, Teruya K, Gatanaga H, Kikuchi Y, and Oka S, Efficacy and safety of once-daily ritonavir-boosted darunavir plus abacavir/lamivudine for treatment-naïve patients: A pilot study. AIDS (Research letter) 26: 649-651, 2012.

 

Nishijima T, Gatanaga H, Komatsu H, Tsukada K, Shimbo T, Aoki T, Watanabe K, Kinai E, Honda H, Tanuma J, Yazaki H, Honda M, Teruya K, Kikuchi Y, and Oka S, Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection. PLoS One 7: e29977, 2012.

 

Hamada Y, Nagata N, Honda H, Asayama N, Teruya K, Ikari T, Kikuchi Y, and Oka S, Epstein–Barr virus associated colitis in an HIV-infected patient. AIDS (Correspondence) 26: 400-402, 2012.

  Hayashida T, Gatanaga H, Takahashi Y, Negishi F, Kikuchi Y, and Oka S, Trends in early identification of HIV-1 infection in Tokyo from 2002 to 2009 analyzed with BED assay. Int J Infect Dis 16: e172-e177, 2012.
 
 


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