{"id":309,"date":"2019-11-10T20:23:12","date_gmt":"2019-11-10T11:23:12","guid":{"rendered":"https:\/\/kumamoto-u-jrchri.jp\/?page_id=309"},"modified":"2024-04-10T10:19:21","modified_gmt":"2024-04-10T01:19:21","slug":"laureate","status":"publish","type":"page","link":"https:\/\/kumamoto-u-jrchri.jp\/en\/laureate\/","title":{"rendered":"Best Paper Award"},"content":{"rendered":"<div id=\"bloc-15\" class=\"bloc bgc-black bg-top-06 d-bloc\">\n<div class=\"container bloc-md\">\n<div class=\"row\">\n<div class=\"col\">\n<h1 class=\"text-lg-center text-center tc-white h1-style mg-clear mg-clear-xs\">Topics<\/h1>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- bloc-15 END --><\/p>\n<p><!-- bloc-16 --><\/p>\n<div id=\"bloc-16\" class=\"bloc tc-onyx l-bloc\">\n<div class=\"container bloc-lg\">\n<div class=\"row\">\n<div class=\"col-lg-12\">\n<h2 class=\"text-center mg-sm-xs mg-sm-md float-none tit-h2 mg-lg\">\u30d9\u30b9\u30c8\u30da\u30fc\u30d1\u30fc\u8cde<\/h2>\n<p class=\"text-lg-center mg-clear\">2002\u5e74\u3088\u308a\u8a2d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"text-center\" style=\"display: none;\"><a class=\"btn btn-d btn-sq btn-lg blue-button\" href=\"https:\/\/kumamoto-u-jrchri.jp\/recruitment\">2018\u5e74\u5ea6\u306e\u52df\u96c6\u306f\u7d42\u4e86\u3057\u307e\u3057\u305f<\/a><\/div>\n<h3 class=\"mg-md tit-h3\">\u53d7\u8cde\u8005\u4e00\u89a7<\/h3>\n<p><!-- \u30b7\u30e7\u30fc\u30c8\u30b3\u30fc\u30c9\u51fa\u529b File Directry: \/custom-shortcode\/laureate-en --><br \/>\n<!-- \u30d9\u30b9\u30c8\u30da\u30fc\u30d1\u30fc\u8cde\u306e\u30a2\u30a6\u30c8\u30d7\u30c3\u30c8 -->\n<!-- Custom filed name: \u30d9\u30b9\u30c8\u30d1\u30fc\u30d1\u30fc\u8cde -->\n\n<!--<h3 class=\"mg-md tit-h3\"><\/h3>-->\n<div>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2025\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u30b0\u30e9\u30f3\u30d7\u30ea  \u83c5\u7530\u3000\u8b19\u6cbb\uff08\u30b2\u30ce\u30df\u30af\u30b9\u30fb\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30df\u30af\u30b9\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/doi.org\/10.1038\/s41564-025-02006-7\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Intragenic viral silencer element regulates HTLV-1 latency via RUNX complex recruitment<\/p>\n<p>Kenji Sugata1,15, Akhinur Rahman1,15, Koki Niimura1,2, Kazuaki Monde 3,Takaharu Ueno 4, Samiul Alam Rajib1, Mitsuyoshi Takatori1, Wajihah Sakhor1,Md Belal Hossain 1, Sharmin Nahar Sithi 1, M. Ishrat Jahan1, Kouki Matsuda5,Mitsuharu Ueda 6, Yoshihisa Yamano7,8, Terumasa Ikeda 9, Takamasa Ueno 10,Kiyoto Tsuchiya 11, Yuetsu Tanaka12, Masahito Tokunaga 13, Kenji Maeda5, Atae Utsunomiya 13, Kazu Okuma4, Masahiro Ono 14 &amp; Yorifumi Satou<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        \n<\/div>\n<!--<h3 class=\"mg-md tit-h3\"><\/h3>-->\n<div>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2025\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6e96\u30b0\u30e9\u30f3\u30d7\u30ea\u3000\u5f8c\u85e4\u3000\u7531\u6bd4\u53e4\uff08\u718a\u672c\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u7814\u7a76\u90e8\u547c\u5438\u5668\u5185\u79d1\u5b66\u8b1b\u5ea7\u3000\u533b\u54e1\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-63288-3\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope<\/p>\n<p>Yoshihiko Goto1,2,16, You Min Ahn 3,4,16, Mako Toyoda1, Hiroshi Hamana5, Yan Jin1, Yoshiki Aritsu1, Takeshi Nakama1, Yuka Tajima1,2, Janesha C. Maddumage3,4, Huanyu Li1, Mizuki Kitamatsu6, Hiroyuki Kishi 5, Akiko Yonekawa7, Dhilshan Jayasinghe3,4, Nobuyuki Shimono7, Yoji Nagasaki8, Rumi Minami9, Takashi Toya10, Noritaka Sekiya 11,12, Yusuke Tomita2,<br \/>\nDemetra S. M. Chatzileontiadou3,4,13, Hirotomo Nakata14, So Nakagawa 15, Takuro Sakagami2, Takamasa Ueno 1, StephanieGras 3,4,13 &amp; Chihiro Motozono<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        \n<\/div>\n<!--<h3 class=\"mg-md tit-h3\"><\/h3>-->\n<div>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2024\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6e96\u30b0\u30e9\u30f3\u30d7\u30ea Shashwata Biswas\uff08\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u30fb\u8840\u6db2\u75be\u60a3\u7814\u7a76\u5171\u540c\u7814\u7a76\u8b1b\u5ea7\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/wp-content\/uploads\/2025\/03\/Reprint_Shashwata-Biswas.pdf\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Idiotopes of antibodies against HIV-1 CD4-induced epitope shared with those against microorganisms<\/p>\n<p>Shashwata Biswas1 | Takeo Kuwata1 | Soichiro Yamauchi2 | Kyo Okazaki2 |<br \/>\nYu Kaku1 | Md Zahid Hasan1 | Hiroshi Morioka2 | Shuzo Matsushita1<\/p>\n<p>https:\/\/doi.org\/10.1111\/imm.13742<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2024\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6e96\u30b0\u30e9\u30f3\u30d7\u30ea  Omnia Reda\uff08\u30b2\u30ce\u30df\u30af\u30b9\u30fb\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30df\u30af\u30b9\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/wp-content\/uploads\/2025\/03\/Omnia-Reda_HIV-Tocky-system-to-visualize-proviral-expression-dynamics.pdf\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>HIV-Tocky system to visualize proviral expression dynamics<\/p>\n<p>Omnia Reda 1,2, Kazuaki Monde 3, Kenji Sugata1, Akhinur Rahman1, Wajihah Sakhor1,<br \/>\nSamiul Alam Rajib 1, Sharmin Nahar Sithi 1, Benjy Jek Yang Tan 1, KokiNiimura4,<br \/>\nChihiro Motozono 5, Kenji Maeda6, MasahiroOno 7, Hiroaki Takeuchi 8 &amp; Yorifumi Satou 1<\/p>\n<p>https:\/\/doi.org\/10.1038\/s42003-024-06025-8<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        \n<\/div>\n<!--<h3 class=\"mg-md tit-h3\"><\/h3>-->\n<div>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2023\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u30b0\u30e9\u30f3\u30d7\u30ea\u3000Emmanuel Nkuwi\uff08\u611f\u67d3\u514d\u75ab\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.00823-23\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Emmanuel Nkuwi, George P. Judicate, Toong Seng Tan, Godfrey Barabona, Mako Toyoda, Bruno Sunguya, Doreen Kamori, Takamasa Ueno.<\/p>\n<p>Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity<\/p>\n<p>Journal of Virology<\/p>\n<p>DOI: 10.1128\/jvi.00823-23<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2023\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6e96\u30b0\u30e9\u30f3\u30d7\u30ea\u3000\u6e05\u6c34  \u51cc\uff08\u5206\u5b50\u30a6\u30a4\u30eb\u30b9\u30fb\u907a\u4f1d\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/mbio.00782-23 \" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Terumasa Ikeda#, Ryo Shimizu#, Hesham Nasser, Michael A. Carpenter, Adam Z. Cheng, William L. Brown, Daniel Saute, Reuben S. Harris<\/p>\n<p>APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1<\/p>\n<p>mBio 14, e0078223 (2023)<\/p>\n<p>#contributed equally.<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2022\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u30b0\u30e9\u30f3\u30d7\u30ea\u3000\u672c\u5712\u3000\u5343\u5c0b\uff08\u611f\u67d3\u514d\u75ab\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/wp-content\/uploads\/2023\/03\/Motozono-et-al-Nat-Commun-2022.pdf\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><span lang=\"EN-US\">Chihiro Motozono (First &amp; Co-corresponding author), Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Yoshihiko Goto, Yoshiki Aritsu, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Seiji Okada, Keiko Udaka, Mizuki Kitamatsu, Hiroyuki Kishi &amp; Takamasa Ueno (Co-corresponding author)<\/span> <span lang=\"EN-US\">The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition.<\/span><span lang=\"EN-US\"> Nature Communications, 13(1):5440, 2022<\/span><\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2021\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u30b0\u30e9\u30f3\u30d7\u30ea\u3000\u672c\u5712\u3000\u5343\u5c0b\uff08\u611f\u67d3\u514d\u75ab\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/doi.org\/10.1016\/j.chom.2021.06.006\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*co-corresponding authors) SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. Cell Host and Microbe 29(7):1124-1136, 2021<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2021\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6e96\u30b0\u30e9\u30f3\u30d7\u30ea\u3000Benjy Tan Jek Yang\uff08\u30b2\u30ce\u30df\u30af\u30b9\u30fb\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30df\u30af\u30b9\u5b66\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/doi.org\/10.1172\/JCI150472\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Benjy J.Y. Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono, Yorifumi Satou. HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia\/lymphoma. Journal of Clinical Investigation, 2021;131(24):e150472.<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2020\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u8d64\u661f \u667a\u5bdb\uff08\u56fd\u969b\u9023\u643a\u5206\u91ce\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2019-2020.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Akahoshi, T., Gatanaga, H., Kuse,N., Chikata, T., Koyanagi, M., Ishizuka, N.,<br \/>\nBrumme, C. J., Murakoshi, H., Brumme, Z. L., Oka, S., and Takiguchi, M., T-cell<br \/>\nresponses to sequentially emerging viral escape mutants shape long-term HIV-1<br \/>\npopulation dynamics, PLoS Pathog. e1009177, 2020<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2019\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u52dd\u5c4b \u5f18\u96c4\uff08\u4f50\u85e4\u7814\u7a76\u5ba4\u3000\u7279\u4efb\u52a9\u6559\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p><strong>Hiroo Katsuya<\/strong>, Saiful Islam, Benjy Jek Yang Tan, Jumpei Ito, Paola Miyazato, Misaki Matsuo, Yuki Inada, Saori C. Iwase, Yoshikazu Uchiyama, Hiroyuki Hata, Tomoo Sato, NaokoYagishita, Natsumi Araya, Takaharu Ueno, Kisato Nosaka, Masahito Tokunaga, Makoto Yamagishi, Toshiki Watanabe, Kaoru Uchimaru, Jun-ichi Fujisawa, Atae Utsunomiya, Yoshihisa Yamano, Yorifumi Satou, The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach, <strong>Cell Reports<\/strong>, 724-735.e4, 2019<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2019\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u4e45\u4e16 \u671b\uff08\u6edd\u53e3\u7814\u7a76\u5ba4\u3000\u7279\u4efb\u8b1b\u5e2b\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2019-2020.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p class=\"p1\"><span class=\"s1\"><b>Nozomi Kuse<\/b>, Xiaoming Sun, Tomohiro Akahoshi, Anna Lissina, Takuya Yamamoto, Victor Appay, and Masafumi Takiguchi, Priming of HIV-1-specific CD8+ T cells with strong functional properties from na\u00efve T cells. <b>EBioMedicine<\/b>. 42:109-119, 2019<\/span><\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2018\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        Rokeya Siddiqui\uff08\u6709\u6d77\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000Doctoral Student\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p class=\"p1\"><span class=\"s1\"><b>Rokeya Siddiqui<\/b>, Shinya Suzu, Mikinori Ueno, Hesham Nasser, Ryota Koba, Farzana Bhuyan, Osamu Noyori, Sofiane Hamidi, Guojun Sheng, Mariko Yasuda-Inoue, Takayuki Hishiki, Sayaka Sukegawa, Eri Miyagi, Klaus Strebel, Shuzo Matsushita, Kunitada Shimotohno, Yasuo Ariumi, Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages, <b>PLoS Pathog.<\/b> 14(11): e1007372, 2018<\/span><\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2017\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u8fd1\u7530 \u8cb4\u656c\uff08\u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u7279\u5b9a\u4e8b\u696d\u7814\u7a76\u54e1\uff09<br>\n                                        \u6751\u8d8a \u52c7\u4eba\uff08\u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u7279\u4efb\u8b1b\u5e2b\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2017-2018.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Takayuki Chikata*, Hayato Murakoshi<\/strong>,* Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi\u3000(*Equal contribution), Control of HIV-1 by an HLA-B*52:01-C*12:02 protective haplotype, J. Infect. Dis. 216:1415-1424, 2017<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2016\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6797\u3000\u6e5b\u677e\uff08\u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u30ea\u30b5\u30fc\u30c1\u30fb\u30b9\u30da\u30b7\u30e3\u30ea\u30b9\u30c8\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2015-2016.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Zhansong Lin<\/strong>, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi, HIV-1 control by NK cells via reduced interaction between KIR2DL2 and HLA-C*12:02\/C*14:03, <strong>Cell Reports<\/strong> 17:2210-2220, 2016<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2015\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u6751\u8d8a \u52c7\u4eba\uff08\u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u7279\u4efb\u52a9\u6559\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2015-2016.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Hayato Murakoshi<\/strong>, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. <strong>J. Virol<\/strong>. 89:5330-5339, 2015<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2014\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u8fd1\u7530 \u8cb4\u656c\uff08\u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u7814\u7a76\u54e1\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2013-2014.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Takayuki Chikata<\/strong>, Jonathan M. Carlson, Yoshiko Tamura, Mohamed Ali Borghan, Takuya Naruto, Masao Hashimoto, Hayato Murakoshi, Anh Q. Le, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, Zabrina L. Brumme, and Masafumi Takiguchi, Host-specific adaptation of HIV-1 subtype B in the Japanese population, <strong>J.Virol<\/strong>. 88:4764-4775, 2014<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2013\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u7aef\u672c \u660c\u592b\uff082012\u5e742\u6708\u307e\u3067\uff1a \u6edd\u53e3\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u52a9\u6559\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2013-2014.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p>Kristin Ladell*, <strong>Masao Hashimoto<\/strong>*, Maria Candela Iglesias*, Pascal G. Wilmann*, James E. McLaren, Stephanie Gras, Takayuki Chikata, Nozomi Kuse, Solene Fastenackels, Emma Gostick, John S.<br \/>\nBridgeman, Vanessa Venturi, Zaina Ait Arkoub, Henri Agut, David J.van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi**, Jamie Rossjohn**, David A.<br \/>\nPrice** and Victor Appay** (*,** Equal contribution), A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. <strong>Immunity<\/strong> 38:425-436, 2013<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2012\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u897f\u5cf6 \u5065\uff08\u5ca1\u30fb\u6f5f\u6c38\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u7814\u7a76\u5ba4\u3000\u535a\u58eb\u8ab2\u7a0b2\u5e74\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p><strong>Takeshi Nishijima<\/strong>, Hirokazu Komatsu, Koichiro Higasa, Misao Takano, Kiyoto Tsuchiya, Tsunefusa Hayashida,Shinichi Oka, and Hiroyuki Gatanaga, Single Nucleotide Polymorphisms in ABCC2 Associate With Tenofovir-Induced Kidney Tubular Dysfunction in Japanese Patients With HIV-1 Infection: A Pharmacogenetic Study, <strong>Clin Infect Dis<\/strong>. 55(11):1558-67, 2012<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2009\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u5ddd\u5cf6 \u5915\u4f73\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u30002007\u5e74\u5ea6\u535a\u58eb\u8ab2\u7a0b\u4fee\u4e86\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2009-2010.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Yuka Kawashima<\/strong>, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung\u2019u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi*, and Philip Goulder* (*equally contribution) Adaptation of HIV-1 to Human Leukocyte Antigen class I . <strong>Nature<\/strong> 458: 641-645, 2009<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2008\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u8702\u8c37 \u6566\u5b50\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u3000\u535a\u58eb\u8ab2\u7a0b4\u5e74\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p><strong>Atsuko Hachiya<\/strong>, Eiichi N. Kodama, Stefan G. Sarafianos, Matthew M. Schuckmann, Yasuko Sakagami, Masao Matsuoka, Masafumi Takiguchi, Hiroyuki Gatanaga, Shinichi Oka. Amino Acid Mutation N348I in the Connection Subdomain of HIV-1 Reverse Transcriptase Confers Multi-class Resistance to Nucleoside and Non-nucleoside Reverse Transcriptase Inhibitors. <strong>J. Virol<\/strong>. 82:3261-3270, 2008<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2007\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u4e0a\u91ce \u8cb4\u5c06\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u3000\u51c6\u6559\u6388\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2007-2008.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Takamasa Ueno<\/strong>, Yuka Idegami, Chihiro Motozono, Shinichi Oka and Masafumi Takiguchi, Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs <strong>J. Immunol<\/strong>. 178: 5513-5523, 2007<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2006\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u9ad8\u7530 \u6bd4\u5442\u5fd7\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u3000\u535a\u58eb\u8ab2\u7a0b3\u5e74\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2005-2006.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Hiroshi Takata<\/strong> and Masafumi Takiguchi, Three memory subsets of human CD8+ T cells differently expressing 3 cytolytic effector molecules. <strong>J Immunol<\/strong>. 177: 4330-4340, 2006<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2005\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u9234 \u4f38\u4e5f\uff08\u4e88\u9632\u958b\u767a\u5206\u91ce\u3000\u8b1b\u5e2b\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p><strong>Shinya Suzu<\/strong>, Hideki Harada, Takahiro Matsumoto, and Seiji Okada, HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities, <strong>Blood<\/strong>, 105: 3230 &#8211; 3237, 2005<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2004\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u9ad8\u7530 \u6bd4\u5442\u5fd7\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u3000\u535a\u58eb\u8ab2\u7a0b1\u5e74\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/laureate\/%E2%98%85\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Hiroshi Takata<\/strong>, Hiroko Tomiyama, Mamoru Fujiwara, Naoki Kobayashi, and Masafumi Takiguchi, Cutting edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells.\u3000<strong>J Immunol<\/strong>. 173(4):2231-2235, 2004<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2003\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u5c0f\u7cf8 \u539a\uff08\u75c5\u614b\u5236\u5fa1\u5206\u91ce\u3000\u8b1b\u5e2b\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                    <\/td>\n                <td>\n                    <p><strong>Atsushi Koito<\/strong>, Yuichi Kameyama, Cecilia Cheng-Mayer, and Shuzo Matsushita , Susceptibility of mink (Mustera vision)-derived cells to replication by human immunodeficiency virus type 1, <strong>J. Virol<\/strong>. 77, 5109-5117, 2003<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        <table class=\"ta-type1\">\n        <thead>\n            <tr>\n                <th width=\"15%\">2002\u5e74\u53d7\u8cde<\/th>\n                <th>\n                                        \u4e0a\u91ce \u8cb4\u5c06\uff08\u30a6\u30a4\u30eb\u30b9\u5236\u5fa1\u5206\u91ce\u3000\u8b1b\u5e2b\uff09<br>\n                                    <\/th>\n            <\/tr>\n            <tr>\n                <td>\n                                            <a href=\"https:\/\/kumamoto-u-jrchri.jp\/takiguchi\/viral\/gyouseki\/omo\/gyouseki2001-2004.htm\" target=\"_blank\">\u8981\u65e8<\/a>\n                                    <\/td>\n                <td>\n                    <p><strong>Takamasa Ueno<\/strong>, Hiroko Tomiyama, Masafumi Takiguchi, Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA calss I molecules. <strong>J.Immunol<\/strong>. 169:4961-4969. 2002<\/p>\n                <\/td>\n            <\/tr>\n        <\/thead>\n    <\/table>\n        \n<\/div>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!-- bloc-16 END --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Topics \u30d9\u30b9\u30c8\u30da\u30fc\u30d1\u30fc\u8cde 2002\u5e74\u3088\u308a\u8a2d\u7f6e\u3057\u3066\u3044\u307e\u3059\u3002 2018\u5e74\u5ea6\u306e\u52df\u96c6\u306f\u7d42\u4e86\u3057\u307e\u3057\u305f \u53d7\u8cde\u8005\u4e00\u89a7<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-309","page","type-page","status-publish","hentry","en-US"],"_links":{"self":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/pages\/309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/comments?post=309"}],"version-history":[{"count":12,"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/pages\/309\/revisions"}],"predecessor-version":[{"id":2173,"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/pages\/309\/revisions\/2173"}],"wp:attachment":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/wp-json\/wp\/v2\/media?parent=309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}