{"id":15,"date":"2026-03-10T15:05:23","date_gmt":"2026-03-10T06:05:23","guid":{"rendered":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/?page_id=15"},"modified":"2026-03-11T13:56:12","modified_gmt":"2026-03-11T04:56:12","slug":"research","status":"publish","type":"page","link":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/research\/","title":{"rendered":"\u7814\u7a76"},"content":{"rendered":"<div class=\"page_nav\">\n<ul>\n<li><a href=\"#anc_research01\">\u4e00\u822c\u306e\u65b9\u3078<\/a><\/li>\n<li><a href=\"#anc_research02\">\u7814\u7a76\u8005\u306e\u65b9\u3078<\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"anc_research01\">\n<h3>\u4e00\u822c\u306e\u65b9\u3078<\/h3>\n<div class=\"research_content_box\">\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d2\u30c8\u306e\u304b\u3089\u3060\u3092\u5b88\u308b\u30d2\u30c8\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7279\u306b\u3001\u30d2\u30c8\u7d30\u80de\u6027\u514d\u75ab\u3092\u62c5\u3063\u3066\u3044\u308bT\u7d30\u80de\u306b\u7740\u76ee\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u306a\u3089\u3073\u306b\u816b\u760d\u306a\u3069\u306e\u7570\u7269\u3092\u611f\u77e5\u3059\u308b\u30d2\u30c8T\u7d30\u80de\u514d\u75ab\u53d7\u5bb9\u4f53\u3068\u305d\u306e\u30ea\u30ac\u30f3\u30c9\u3068\u306e\u5206\u5b50\u8a8d\u8b58\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u7814\u7a76\u3092\u7a4d\u307f\u91cd\u306d\u308b\u3053\u3068\u3067\u3001\u69d8\u3005\u306a\u611f\u67d3\u75c7\u306a\u3089\u3073\u306b\u304c\u3093\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u30ef\u30af\u30c1\u30f3\u306a\u3089\u3073\u306b\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u306b\u7e4b\u3052\u305f\u3044\u3068\u52aa\u529b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<hr \/>\n<div id=\"anc_research02\">\n<h3>\u7814\u7a76\u8005\u306e\u65b9\u3078<\/h3>\n<div class=\"research_content_box\">\n<div class=\"researcher_wrap\">\n<h4>\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u304a\u3051\u308b\u30d2\u30c8\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u6297\u539f\u8a8d\u8b58\u6a5f\u69cb\u306e\u89e3\u660e<\/h4>\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u304a\u3051\u308b\u30d2\u30c8\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306e\u6297\u539f\u8a8d\u8b58\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u7814\u7a76\u306e\u904e\u7a0b\u3067\u3001\u8fd1\u5e74\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u3064\u3044\u3066\u3001SARS-CoV-2\u5909\u7570\u682a\u306e\u514d\u75ab\u9003\u907f\u6a5f\u5e8f\u3001\u5909\u7570\u682a\u306b\u5bfe\u3059\u308b\u30ef\u30af\u30c1\u30f3\u8a98\u5c0e\u578bT\u7d30\u80de\u5fdc\u7b54\u3001\u65e5\u672c\u4eba\u3067\u5f37\u304f\u8a98\u5c0e\u3055\u308c\u308b\u6a5f\u80fd\u7684\u306aT\u7d30\u80de\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u4ed6\u306e\u30a6\u30a4\u30eb\u30b9\u3001\u7279\u306b\u96e3\u6cbb\u6027\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308bT\u7d30\u80de\u5fdc\u7b54\u306e\u89e3\u6790\u306b\u5c55\u958b\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<ul>\n<li>Motozono, C. et al. <em><strong>Cell Host &#038; Microbe<\/strong><\/em> 29(7):1124-1136.e11., 2021.<\/li>\n<li>Motozono, C* et al. <em><strong>Nature Communications<\/strong><\/em> 13(1):5440, 2022.<\/li>\n<li>Goto, Y#., Ahn, YM#., Gras, S*., Motozono, C* et al. <em><strong>Nature Communications<\/strong><\/em>, 16(1):8062, 2025.<\/li>\n<li>Nakama, T., Wall, A#., Dolton, G#. Sewell, AK*, Motozono, C.* et al. <em><strong>JCI insight<\/strong><\/em>, in press, 2026<\/li>\n<\/ul><\/div>\n<div class=\"researcher_wrap\">\n<h4>\u975e\u30da\u30d7\u30c1\u30c9\u6210\u5206\u3092\u611f\u77e5\u3059\u308b\u30d2\u30c8\u81ea\u7136\u514d\u75ab\u578bT\u7d30\u80de\u306e\u6297\u539f\u8a8d\u8b58\u6a5f\u69cb\u306e\u89e3\u660e<\/h4>\n<p>\u4e0a\u8a18\u306e\u75c5\u539f\u4f53\u306b\u7279\u7570\u7684\u306a\u30d2\u30c8\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\u306f\u3001HLA\uff08\u30d2\u30c8\u767d\u8840\u7403\u6297\u539f\uff09\u5206\u5b50\u306b\u63d0\u793a\u3055\u308c\u305f\u75c5\u539f\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u7531\u6765\u306e\u6297\u539f\u30da\u30d7\u30c1\u30c9\uff088-14\u30a2\u30df\u30ce\u9178\u304b\u3089\u6210\u308b\uff09\u3092\u8a8d\u8b58\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u8fd1\u5e74\u3001\u7570\u5e38\u306a\u4ee3\u8b1d\u7523\u7269\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u4f53\u306e\u4ee3\u8b1d\u7570\u5e38\u3092\u611f\u77e5\u3059\u308b\u3001\u65b0\u305f\u306a\u30d2\u30c8\u81ea\u7136\u514d\u75ab\u578bT\u7d30\u80de\uff08\u03b3\u03b4T\u7d30\u80de\u3001MAIT\u7d30\u80de\u3001NKT\u7d30\u80de\u306a\u3069\uff09\u304c\u811a\u5149\u3092\u6d74\u3073\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u6700\u8fd1\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u6210\u5206\u306b\u53cd\u5fdc\u3059\u308b\u81ea\u7136\u514d\u75ab\u578bT\u7d30\u80de\u3092\u540c\u5b9a\u3057\u3001\u305d\u308c\u3089\u304c\u816b\u760d\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u3001\u6bba\u50b7\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u611f\u67d3\u75c7\u7814\u7a76\u306b\u5c55\u958b\u3057\u3001\u6a5f\u80fd\u7684\u306a\u30d2\u30c8\u81ea\u7136\u514d\u75ab\u578bT\u7d30\u80de\u306b\u5099\u308f\u3063\u305fT\u7d30\u80de\u53d7\u5bb9\u4f53\u306a\u3089\u3073\u306b\u305d\u306e\u30ea\u30ac\u30f3\u30c9\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u3084\u30ef\u30af\u30c1\u30f3\u3001\u306a\u3089\u3073\u306b\u3001\u65b0\u305f\u306a\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u306b\u7e4b\u3052\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<ul>\n<li>Shibata, K, Motozono, C., et al. <em><strong>Nature Communications<\/strong><\/em>, 13(1):6948, 2022.<\/li>\n<li>Goto, Y#., Dolton, G#., Tomita, Y*., Sewell, AK*, and Motozono, C*. <em><strong>Frontiers in Immunology<\/strong><\/em>, In press, 2026.<\/li>\n<\/ul><\/div>\n<div class=\"researcher_wrap\">\n<h4>\u6a5f\u80fd\u7684\u306aT\u7d30\u80de\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u4eba\u5de5T\u7d30\u80de\u6297\u539f\u306e\u958b\u767a<\/h4>\n<p>\u30d2\u30c8T\u7d30\u80de\u304c\u8a8d\u8b58\u3059\u308b\u6297\u539f\u3092\u65b0\u305f\u306a\u30e2\u30c0\u30ea\u30c6\u30a3\u3068\u3057\u3066\u6349\u3048\u3001\u305d\u308c\u3089\u3092T\u7d30\u80de\u304b\u3089\u8a8d\u8b58\u3055\u308c\u3084\u3059\u3044\u3088\u3046\u306b\u5408\u7406\u7684\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u3001\u6a5f\u80fd\u7684\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u65b0\u305f\u306aT\u7d30\u80de\u8a98\u5c0e\u578b\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u82f1\u56fd\u306eOxford\u5927\u5b66\u3068\u306e\u56fd\u969b\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001AI\uff08Artificial intelligence: \u4eba\u5de5\u77e5\u80fd\uff09\u3092\u6d3b\u7528\u3057\u3001\u6a5f\u80fd\u7684\u306aT\u7d30\u80de\u3092\u5408\u7406\u7684\u306b\u30c7\u30b6\u30a4\u30f3\u3059\u308b\u6b21\u4e16\u4ee3\u306e\u30ef\u30af\u30c1\u30f3\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u69cb\u7bc9\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n<ul>\n<li>Aritsu, Y, Motozono, C*., et al. <em><strong>Frontiers in Immunology<\/strong><\/em>, In press, 2026.<\/li>\n<\/ul><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u4e00\u822c\u306e\u65b9\u3078 \u7814\u7a76\u8005\u306e\u65b9\u3078 \u4e00\u822c\u306e\u65b9\u3078 \u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d2\u30c8\u306e\u304b\u3089\u3060\u3092\u5b88\u308b\u30d2\u30c8\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002 \u7279\u306b\u3001\u30d2\u30c8\u7d30\u80de\u6027\u514d\u75ab\u3092\u62c5\u3063\u3066\u3044\u308bT\u7d30\u80de\u306b\u7740\u76ee\u3057\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u7d30\u80de\u306a\u3089\u3073\u306b\u816b\u760d\u306a\u3069\u306e\u7570\u7269\u3092\u611f\u77e5\u3059\u308b\u30d2\u30c8T\u7d30&#8230; <a class=\"view-article\" href=\"https:\/\/kumamoto-u-jrchri.jp\/motozono\/research\/\">View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":4,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":68,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/15\/revisions\/68"}],"wp:attachment":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}