{"id":17,"date":"2026-03-10T15:08:54","date_gmt":"2026-03-10T06:08:54","guid":{"rendered":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/?page_id=17"},"modified":"2026-05-12T10:41:16","modified_gmt":"2026-05-12T01:41:16","slug":"publications","status":"publish","type":"page","link":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/publications\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"<ul>\n<li>Aritsu, Y., Kitabatake, M., Kurose, A., Hamana, H., Nakama, T., Yamada, K., Furukawa, R., Ouji-Sageshima, N., Hara, A., Yasuike, K., Itami, S., Li, H., Udaka, K., Kishi, H., Ueno, T., Nakagawa, S., Ito, T., Kawashita, N., Kitamatsu, M., Motozono, C*. N-terminal pyroglutamylation of an HLA-A24-restricted immunodominant epitope enhances SARS-CoV-2-specific T cell responses, <em><strong>Frontiers in Immunology<\/strong><\/em>,17:1758642, 2026. doi: 10.3389\/fimmu.2026.1758642<span draggable=\"true\"><br \/>\n<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2026.1758642\/full\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2026.1758642\/full<\/a><\/span><\/li>\n<li>Nakama, T#., Wall, A#., Dolton G#., Tan, LR., Thomas, H., Hamana, H., Aritsu, Y., Tan, TS., Toyoda, M., Goto, Y., Li, H., Kitamatsu, K., Udaka, K., Miyashita, Y., Oshiumi, H., Nakamura, K., Nagasaki, Y., Minami, R., Nakata, .H, Rizkallah, PJ., Kishi, H., Ueno, T., Sewell, AK*., Motozono, C*. Position-5\u2013driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T cell escape.\u00a0<em><strong>JCI Insight<\/strong><\/em>, 11(9):e202235, 2026. \u00a0doi: 10.1172\/jci.insight.202235.<br \/>\n<span draggable=\"true\"><a href=\"https:\/\/insight.jci.org\/articles\/view\/202235\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/insight.jci.org\/articles\/view\/202235<\/a><\/span><\/li>\n<li>Goto, Y#., Dolton, G#., Thomas, H., Morin, T., Tajima, Y., Imamura, K, Sakata, S., Oka, K., Hayashi, A., Takahashi, M., Ueno, T., Sakagami, T., Tomita, Y*., Sewell, AK*, and Motozono, C*. A probiotic bacterium modulates antitumor \u03b3\u03b4 T-cell responses in lung cancer. <em><strong>Frontiers in Immunology<\/strong><\/em>, 17:1750569, 2026. doi: 10.3389\/fimmu.2026.1750569<span draggable=\"true\"><br \/>\n<a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2026.1750569\/full\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2026.1750569\/full<\/a><\/span>.<\/li>\n<li>Goto, Y., Ahn, YM., Toyoda, M., Hamana, H., Jin, Y., Aritsu, Y., Nakama, T., Tajima, Y., Maddumage, JC., Li, H., Kitamatsu, M., Kishi, H., Yonekawa, A., Jayasinghe, D., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Tomita, Y., Chatzileontiadou, DSM., Nakata, H., Nakagawa, S., Sakagami, T., Ueno, T., Gras, S*., Motozono, C*. Molecular basis of potent antiviral HLA-C-restricted CD8+ T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope. <em><strong>Nature Communications<\/strong><\/em>, 16(1):8062, 2025. doi: 10.1038\/s41467-025-63288-3.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-63288-3\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-025-63288-3<\/a><\/li>\n<li>Motozono, C*., Toyoda, M., Tan, TS., Hamana, H., Aritsu, Y., Miyashita, Y., Oshiumi, H., Nakamura, K., Okada, S., Udaka, K., Kitamatsu, M., Kishi, H., Ueno, T*. The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T cell recognition. <em><strong>Nature Communications<\/strong><\/em> 13(1):5440, 2022. *Corresponding equally. doi: 10.1038\/s41467-022-33068-4.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-33068-4\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-022-33068-4<\/a><\/li>\n<li>Shibata, K, Motozono, C., Nagae M., Shimizu, T., Ishikawa, E., Motooka, D., Okuzaki, D., Izumi, Y., Takahashi, M., Fujimori N., Wing JB., Hayano, T., Asai Y., Bamba, T., Ogawa Y., Furutani-Seiki M., Shirai M., Yamasaki S. Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. <em><strong>Nature Communications<\/strong><\/em>, 13(1):6948, 2022. doi: 10.1038\/s41467-022-34802-8.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-34802-8\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/s41467-022-34802-8<\/a><\/li>\n<li>Motozono, C., Toyoda., M, Zahradnik, J., Saito, A., Nasser, H., Tan, TS., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y, Shimizu., R, Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, T*., Nakagawa, S*., Ueno, T*., Sato, K*. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity. <em><strong>Cell Host &amp; Microbe<\/strong><\/em> 29(7):1124-1136.e11., 2021. *Corresponding equally. doi: 10.1016\/j.chom.2021.06.006.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1931312821002845?via%3Dihub\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1931312821002845?via%3Dihub<\/a><\/li>\n<li>Takano, T., Motozono, C*., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S*. Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity. <em><strong>J. Biol. Chem<\/strong><\/em>. 292(41):16933-16941, 2017. *Corresponding equally.\u00a0<span class=\"citation-doi\">doi: 10.1074\/jbc.M117.800847.<\/span>\u00a0<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925820339272?via%3Dihub\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925820339272?via%3Dihub<\/a><\/li>\n<li>Motozono, C#., Pearson, JA#., De Leenheer, E., Rizkallah, PJ., Beck, K., Trimby, A., Sewell, AK., Wong, FS., Cole, DK. Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide. <em><strong>J. Biol. Chem<\/strong><\/em>. 290(31): 18924-18933, 2015. #Contributed equally. doi: 10.1074\/jbc.M114.622522.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925820422616?via%3Dihub\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925820422616?via%3Dihub<\/a><\/li>\n<li>Motozono, C., Bridgeman, JS., Price, DA., Sewell, AK., Ueno, T. Clonotypically similar hybrid \u03b1\u03b2 T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. <em><strong>Clin. Exp. Immunol<\/strong><\/em>. 180(3): 560-570, 2014. doi: 10.1111\/cei.12610.<br \/>\n<a href=\"https:\/\/academic.oup.com\/cei\/article\/180\/3\/560\/6422157\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/cei\/article\/180\/3\/560\/6422157<\/a><\/li>\n<li>Motozono, C#, Kuse, N#., Sun, X., Rizkallah, PJ., Fuller, A., Oka, S., Cole, DK., Sewell, AK., Takiguchi, M. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. <em><strong>J. Immunol<\/strong><\/em>. 192(7): 3428-3434, 2014. #Contributed equally. doi: 10.4049\/jimmunol.1302667.<br \/>\n<a href=\"https:\/\/academic.oup.com\/jimmunol\/article\/192\/7\/3428\/8001551\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/jimmunol\/article\/192\/7\/3428\/8001551<\/a><\/li>\n<li>Motozono, C., Yokoyama, M., Sato, H., Ueno, T. Cross-reactivity analysis of T cell receptors specific for overlapping HIV-1 Nef epitopes of different lengths. <em><strong>Microbes. Infect<\/strong><\/em>. 16(4): 320-327, 2014. <span class=\"citation-doi\">doi: 10.1016\/j.micinf.2013.12.005.<br \/>\n<\/span> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1286457913002669?via%3Dihub\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1286457913002669?via%3Dihub<\/a><\/li>\n<li>Motozono, C., Miles, JJ., Hasan, Z., Gatanaga, H., Meribe, SC., Price, DA., Oka, S., Sewell, AK., Ueno, T. CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. <em><strong>PLoS One<\/strong><\/em>. 8(6): e66152, 2013. <span class=\"citation-doi\">doi: 10.1371\/journal.pone.0066152.<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0066152\" target=\"_blank\" rel=\"noopener\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0066152<\/a><br \/>\n<\/span><\/li>\n<li>Motozono, C., Yanaka, S., Tsumoto, K., Takiguchi, M., Ueno, T. Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral activity of HIV-specific CTL. <em><strong>J. Immunol<\/strong><\/em>. 182(9): 5528-5536, 2009. doi: 10.4049\/jimmunol.0803471.<br \/>\n<a href=\"https:\/\/academic.oup.com\/jimmunol\/article\/182\/9\/5528\/8007681\" target=\"_blank\" rel=\"noopener\">https:\/\/academic.oup.com\/jimmunol\/article\/182\/9\/5528\/8007681<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"Aritsu, Y., Kitabatake, M., Kurose, A., Hamana, H., Nakama, T., Yamada, K., Furukawa, R., Ouji-Sageshima, N., &#8230; <a class=\"view-article\" href=\"https:\/\/kumamoto-u-jrchri.jp\/motozono\/publications\/\">View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":10,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":247,"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/pages\/17\/revisions\/247"}],"wp:attachment":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/motozono\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}