Publications


2021年度

Yu Zhang, Takayuki Chikata, Nozomi Kuse, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Immunological control of HIV-1 disease progression by rare protective HLA allele. J. Virol. 96 e01248-22, 2022

 

 

Toong Seng Tan, Mako Toyoda, Hirotaka Ode, Godfrey Barabona, Hiroshi Hamana, Mizuki Kitamatsu, Hiroyuki Kishi, Chihiro Motozono, Yasumasa Iwatani, Takamasa Ueno, Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike, Journal of Virology, Vol. 96,  2001162-22, 2022

 

詳しくはこちら→

Nozomi Kuse,* Yu Zhang,* Takayuki Chikata,* Hung The Nguyen, Shinichi Oka, Hiroyuki Gatanaga, and Masafumi Takiguchi (*equal contribution), Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine, Nat. Commun. 13: 5251, 2022

詳しくはこちら

Hung The Nguyen*, Nozomi Kuse*, Yu Zhang, Hayato Murakoshi, Yosuke Maeda, Yoshiko Tamura, Rie Maruyama, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Shinichi Oka, Takayuki Chikata, and Masafumi Takiguchi (*equal contribution), Control of HIV-1 replication by CD8+ T cells specific for two novel Pol protective epitopes in HIV-1 subtype A/E infection, J. Virol, 96: e00811-22, 2022

詳しくはこちら

本園千尋 講師、豊田真子 特任助教、Tan Toong Seng研究員らの新型コロナウイルスオミクロン株に対するT細胞応答に関する研究成果が、Nature Communications誌に公開されました!

 

プレスリリース:オミクロンBA.1株のG446S変異がワクチン誘導型T細胞の抗ウイルス機能を高めることを発見

 

Nasser H, Takahashi N, Eltalkhawy YM, Reda O, Lotfi S, Nasu K, Sakuragi J, Suzu S. Inhibitory and stimulatory effects of IL-32 on HIV-1 infection. J Immunol 209:970-978, 2022

 

URL: https://www.jimmunol.org/content/early/2022/08/05/jimmunol.2200087

Takayuki Chikata, Wayne Paes, Nozomi Kuse, Thomas Partridge, Hiroyuki Gatanaga, Yu Zhang, Kimiko Kuroki, Katsumi Maenaka, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Impact of micropolymorphism outside the peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection, J. Virol. 96: e00432-22, 2022

詳しくはこちら

Daichi Yamasoba#, Izumi Kimura#, Hesham Nasser#, Yuhei Morioka#, Naganori Nao#, Jumpei Ito#, Keiya Uriu#, Masumi Tsuda#, Jiri Zahradnik#, Kotaro Shirakawa, Rigel Suzuki, Mai Kishimoto, Yusuke Kosugi, Kouji Kobiyama, Teppei Hara, Mako Toyoda, Yuri L. Tanaka, Erika P. Butlertanaka, Ryo Shimizu, Hayato Ito, Lei Wang, Yoshitaka Oda, Yasuko Orba, Michihito Sasaki, Kayoko Nagata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Jin Kuramochi, Motoaki Seki, Ryoji Fujiki, Atsushi Kaneda, Tadanaga Shimada, Taka-aki Nakada, Seiichiro Sakao, Takuji Suzuki, Takamasa Ueno, Akifumi Takaori-Kondo, Ken J. Ishii, Gideon Schreiber, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hirofumi Sawa, Akatsuki Saito*, Takashi Irie*, Shinya Tanaka*, Keita Matsuno*, Takasuke Fukuhara*, Terumasa Ikeda*, Kei Sato*.   (#Equal contribution; *Corresponding author)

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. 2022

DOI: 10.1016/j.cell.2022.04.035

URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00533-5

Yasuo Ariumi, Host cellular RNA helicases regulate SARS-CoV-2 infection, J. Virol. 2022.

Benjy Jek Yang Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono and Yorifumi Satou

DOI:10.1172/JCI150472

JCI
熊本大学
Imperial College
London

Masateru Hiyoshi, Naofumi Takahashi, Youssef M. Eltalkhawy, Osamu Noyori, Sameh Lotfi, Jutatip Panaampon, Seiji Okada, Yuetsu Tanaka, Takaharu Ueno, Jun-ichi Fujisawa, Yuko Sato, Tadaki Suzuki, Hideki Hasegawa, Shinya Suzu, M-Sec induced by HTLV-1 mediates an efficient viral transmission, Plos Pathogens, 2021

DOI:org/ 10.1371/journal.ppat.1010126

著者:齊藤暁#, 入江崇#, 鈴木理滋#, 前村忠#, Hesham Nasser#, 瓜生慧也#, 小杉優介#, 白川康
太郎, 貞升健志, 木村出海, 伊東潤平, 呉佳齊, 岩附研子, 伊藤睦美, 山吉誠也, Samantha Loeber,
津田真寿美, Lei Wang, 大園誠也, バトラー田中英里佳, 田中友理, 清水凌, 清水健太, 吉松組子,
川端涼子, 坂口剛正, 徳永研三, 吉田勲, 浅倉弘幸, 長島真美, 数馬安浩, 野村亮介, 堀澤欣史, 吉村
和久, 高折晃史, 今井正樹, The Genotype to Phenotype Japan (G2P-Japan) Consortium, 田中
伸哉*, 中川草*, 池田輝政*, 福原崇介*, 河岡義裕*, 佐藤佳*
(#Equal contribution; *Corresponding author)
熊大プレスリリース

Nozomi Kuse,* Hayato Murakoshi,* Tomohiro Akahoshi,* Takayuki Chikata, Katherine L James, Hiroyuki Gatanaga, Sarah L Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi (*equal contribution), Collaboration of a detrimental HLA-B*35:01 allele with HLA-A*24:02 in co-evolution of HIV-1 with T-cells leading to poorer clinical outcomes, J. Virol. 95: e01259-21, 2021

 

Nozomi Kuse, Tomohiro Akahoshi, and Masafumi Takiguchi, STING ligand-mediated priming of functional CD8+ T-cells specific for HIV-1 protective epitopes from naive T-cells, J. Virol. 95: e00699-21, 2021

 

新型コロナに感染して回復した症例から中和抗体を分離し、ウイルスへの強い結合活性をもった中和抗体が変異株へも有効であることを発表しました。

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Yu Kaku, Takeo Kuwata* Hasan Md Zahid, Takao Hashiguchi, Takeshi Noda, Noriko Kuramoto, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Kazuya Shimura, Chiho Onishi, Yukiko Muramoto, Tateki Suzuki, Jiei Sasaki, Yoji Nagasaki, Rumi Minami, Chihiro Motozono, Mako Toyoda, Hiroshi Takahashi, Hiroto Kishi, Kazuhiko Fujii, Tsuneyuki Tatsuke, Terumasa Ikeda, Yosuke Maeda, Takamasa Ueno, Yoshio Koyanagi, Hajime Iwagoe, and Shuzo Matsushita*

Web site (Cell reports)

プレスリリース (熊本大学)

 

ウイルスの感染力を高め、日本人に高頻度な細胞性免疫応答から免れるSARS-CoV-2変異の発見した論文を発表しました。

Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*corresponding authors)
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.
Cell Host and Microbe (2021)

→ Web site (Cell Host and Microbe 2021 )

→ プレスリリース (熊本大学)

Joint research about bovine leukemia virus with Tokyo University of Agriculture and Tokai University has been published in Scientific Reports. (Division of Genomics and Transcriptomics)

[A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP]

2020年度

Yu Zhang, Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Giang Van Tran, Trung Vu Nguyen, Hiroyuki Gatanaga, Kinh Van Nguyen, Shinichi Oka, Nozomi Kuse, and Masafumi Takiguchi, Effect of difference in consensus sequence between HIV-1 subtype A/E and subtype B viruses on elicitation of Gag-specific CD8+ T cells and accumulation of HLA-associated escape mutations, J. Virol. 95: e02061-20, 2021

Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Chengcheng Zou, Mohamed Ali Borghan, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Nozomi Kuse, and Masafumi Takiguchi, Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15:05 on clinical outcome in HIV-1 subtype A/E infection, AIDS 35: 33-43, 2021  (Division of International Collaboration Research / Takiguchi Lab.)

Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J. Brumme, Hayato Murakoshi, Zabrina L. Brumme, Shinichi Oka, and Masafumi Takiguchi, T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics, PLoS Pathog. 16(12): e1009177, 2020

Joint research with Imperial College London was published in Frontiers in Immunology. [T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis]

→ Web site (Frontiers in Immunology)

→ プレスリリース(AMED)

→ プレスリリース (熊本大学)

Yu Zhang, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Hayato Murakoshi, and Masafumi Takiguchi, Role of escape mutant-specific T cells in suppression of HIV-1 replication and co-evolution with HIV-1, J. Virol. 94:e01151, 2020  (Division of International Collaboration Research / Takiguchi Lab.)

Yamamoto N*, Ariumi Y*(*co-first), Nishida Y, Yamamoto R, Bauer G, Gojobori T, Shimotohno K, Mizokami M.    SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene Jul 3:144944,  2020   (Division of Retrolelement)

2019年度

Katsuya, H., Islam, S., Tan, B., Ito, J., Miyazato, P., Matsuo, M., Inada, Y., Iwase, S., Uchiyama, Y., Hata, H., Sato, T., Yagishita, N., Araya, N., Ueno, T., Nosaka, K., Tokunaga, M., Yamagishi, M., Watanabe, T., Uchimaru, K., Fujisawa, J., Utsunomiya, A., Yamano, Y. and Satou, Y.   The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 29(3), pp.724-735.e4. ,  2019  (Division of Genomics and Transcriptomics)

Iwase SC, Miyazato P, Katsuya H, Islam S, Tan B, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K, and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus. Sci Rep, 9(1):12326, 2019   (Division of Genomics and Transcriptomics)

Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S. Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma. Clinical & Translational Immunology 8 (8): e1074, 2019.   (Division of Infection and Hematopoiesis)

G Barabona, M Mahiti, S Masoud, P Mbelele, A Shaban Mgunya, L Minja, B Sunguya, U Shigemi, M Matsuda, A Hachiya, Y Iwatani, E Lyamuya, T Ueno.  Pre-treatment and acquired HIV drug resistance in Dar es Salaam, Tanzania in the era of tenofovir and routine viral load monitoring. J Antimicrob Chemother https://doi.org/10.1093/jac/dkz272 , 2019  (Division of Infection and Immunity)

Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Identification of immunodominant HIV-1 epitopes presented by HLA-C*12:02, a protective allele, using an immunopeptidomics approach, J. Virol, 93(17), e00634-19,2019   (Division of International Collaboration Research / Takiguchi Lab.)

Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Kato N, Ikeda M, Okimura T, Isaka S, Oda T, Ariumi Y. Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection. Int. J. Biol. Macromol. 124:282-290, 2019.(Division of Retroelement)


Smita Kulkarni, Alexandra Lied, Viraj Kulkarni, Marijana Rucevic, Maureen P. Martin, Victoria Walker-Sperling, Stephen K. Anderson, Rodger Ewy, Sukhvinder Singh, Hoang Nguyen, Paul J. McLaren, Mathias Viard, Vivek Naranbhai, Chengcheng Zou, Zhansong Lin, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi, Chloe L. Thio, Joseph Margolick, Gregory D. Kirk, James J. Goedert, W. Keith Hoots, Steven G. Deeks, David W. Haas, Nelson Michael, Bruce Walker, Sylvie Le Gall, Fatema Z. Chowdhury, Xu G. Yu and Mary Carrington, CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome, Nat Immunol. 20:824-834, 2019(Division of International Collaboration Research / Takiguchi Lab)


Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Anna Lissina, Takuya Yamamoto, Victor Appay, and Masafumi Takiguchi, Priming of HIV-1-specific CD8+ T cells with strong functional properties from naive T cells, EBioMedicine 42:109-119, 2019(Division of International Collaboration Research / Takiguchi Lab)


Chengcheng Zou*, Hayato Murakoshi*, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomas Hanke, and Masafumi Takiguchi (*Equal contribution), Effective suppression of HIV-1 replication by CTLs specific for Pol epitopes in conserved mosaic vaccine immunogens, J. Virol. 93:e02142-18, 2019(Division of International Collaboration Research / Takiguchi Lab)

ヒトレトロウイルス学共同研究センター
ヒトレトロウイルス学共同研究センター 鹿児島大学キャンパス
熊本大学キャンパス
生命化学研究部・教育部
IRCMS
ヒトレトロウイルス学共同研究センター 熊本キャンパス

Copyright @ 2019 Joint Research Center for Human Retrovirus Infection, Kumamoto University