{"id":472,"date":"2022-09-30T11:53:59","date_gmt":"2022-09-30T02:53:59","guid":{"rendered":"https:\/\/kumamoto-u-jrchri.jp\/satou\/?page_id=472"},"modified":"2022-09-30T11:54:54","modified_gmt":"2022-09-30T02:54:54","slug":"%e9%81%8e%e5%8e%bb%e3%81%ae%e7%99%ba%e8%a1%a8%e8%ab%96%e2%bd%82","status":"publish","type":"page","link":"https:\/\/kumamoto-u-jrchri.jp\/satou\/achievements\/old_thesis\/","title":{"rendered":"\u904e\u53bb\u306e\u767a\u8868\u8ad6\u2f42"},"content":{"rendered":"<div class=\"page_nav\">\n<ul>\n<li class=\"active\"><a href=\"\/satou\/achievements\/\">\u767a\u8868\u8ad6\u6587<\/a><\/li>\n<li><a href=\"\/satou\/achievements\/publications\/\">\u5b66\u4f1a\u767a\u8868<\/a><\/li>\n<li><a href=\"\/satou\/achievements\/award\/\">\u53d7\u8cde\u6b74<\/a><\/li>\n<\/ul>\n<\/div>\n<h3>\u904e\u53bb\u306e\u767a\u8868\u8ad6\u2f42<\/h3>\n<h4>2019\u5e74<\/h4>\n<ul>\n<li>Miyazato P, Matsuo M, Tan BJY, Tokunaga M, Katsuya H, Islam S, Ito J, Murakawa Y, <span class=\"auto-style1\">Satou Y<\/span>. HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP. <em><strong>Retrovirology<\/strong><\/em>, 16(1):38, doi: 10.1186\/s12977-019-0500-3,2019.<\/li>\n<li>Katsuya H, Islam S, Tan BJY, Ito J, Miyazato P, Matsuo M, Inada Y, Iwase SC, Uchiyama Y, Hata H, Sato T, Yagishita N, Araya N, Ueno T, Nosaka K, Tokunaga M, Yamagishi M, Watanabe T, Uchimaru K, Fujisawa JI, Utsunomiya A, Yamano Y, <span class=\"auto-style1\">Satou Y<\/span>. The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. <em><strong>Cell Reports<\/strong><\/em>, 29(3):724-735.e4, doi: 10.1016\/j.celrep.2019.09.016, 2019.<\/li>\n<li>Iwase S, Miyazato P, Katsuya H, Islam S, Tan BJY, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K and <span class=\"auto-style1\">Satou Y<\/span>. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus.<br \/>\n<em><strong>Scientific Reports<\/strong><\/em>, 29(3):724-735.e4, doi: 10.1016\/j.celrep.2019.09.016, 2019.<\/li>\n<li>Baba M, Furuya M, Motoshima T, Martin L, Funasaki S, Wenjuan M, Hong-Wei S, Hasumi H, Ying H, Kato I,<br \/>\nKadomatsu T, <span class=\"auto-style1\">Satou Y<\/span>, Nicole MN, Baktiar OK, Lilia I, Joseph DK, Luh AWK, Hasumi Y, Sugiyama A,<br \/>\nKurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T,<br \/>\nOike Y, Laura SS and W. Marston L. TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.<br \/>\n<em><strong>Molecular Cancer Research<\/strong><\/em>, 17(8):1613-1626, doi: 10.1158\/1541-7786.MCR-18-1235, 2019.<\/li>\n<li><u>\u677e\u5c3e\u7f8e\u6c99\u5e0c<\/u>\u3001<u>\u5bae\u91cc\u30d1\u30aa\u30e9<\/u>\u3001<u>\u4f50\u85e4\u8ce2\u6587<\/u><br \/>\n<a class=\"blank\" style=\"text-decoration: none;\" href=\"image\/2019\u30a6\u30a4\u30eb\u30b9\u8a8c\u7dcf\u8aac.pdf\" target=\"_blank\" rel=\"noopener\">\u300cHTLV-1\u611f\u67d3\u7d30\u80de\u30af\u30ed\u30fc\u30f3\u9078\u629e\u306b\u304a\u3051\u308b\u30a6\u30a4\u30eb\u30b9\u7d44\u307f\u8fbc\u307f\u90e8\u4f4d\u306e\u610f\u7fa9<br \/>\n\u301c\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9HTLV-1\u3068\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u8a71\u984c\u301c\u300d<\/a> <strong>\u30a6\u30a4\u30eb\u30b9<\/strong>\u3000\u7b2c69\u5dfb \u7b2c1\u53f7\u30002019\u5e74<\/li>\n<li><u>\u4f50\u85e4\u8ce2\u6587<\/u><a class=\"blank\" style=\"text-decoration: none;\" href=\"image\/2019\u30a8\u30a4\u30ba\u5b66\u4f1a\u8a8c\u7dcf\u8aac.pdf\" target=\"_blank\" rel=\"noopener\">\u300cHIV-1\u30a6\u30a4\u30eb\u30b9\u30ea\u30b6\u30fc\u30d0\u306e\u6210\u7acb\u30fb\u7dad\u6301\u306e\u4ed5\u7d44\u307f\u300d<\/a> <strong>\u65e5\u672c\u30a8\u30a4\u30ba\u5b66\u4f1a\u8a8c<\/strong>\u300021:167-172\u30002019\u5e74<\/li>\n<\/ul>\n<h4>2018\u5e74<\/h4>\n<ul>\n<li>Miura M, Miyazato P, <span class=\"auto-style1\">Satou Y<\/span>, Tanaka Y, Bangham CRM. Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5&#8242; and 3&#8242; long terminal repeats.<br \/>\n<em><strong>Wellcome Open Research<\/strong><\/em>, 3:105, doi: 10.12688\/wellcomeopenres.14741.2. eCollection 2018, 2018.<\/li>\n<li>Katsuya H, Cook LBM, Rowan AG, <span class=\"auto-style1\">Satou Y<\/span>, Taylor GP, Bangham CRM. Phosphatidylinositol 3-kinase-\u03b4 (PI3K-\u03b4) is a potential therapeutic target in adult T-cell leukemia-lymphoma.<br \/>\n<em><strong>Biomarker Research<\/strong><\/em>, 6:24, doi: 10.1186\/s40364-018-0138-7, 2018.<\/li>\n<li>Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T,<br \/>\n<u>Satou Y<\/u>, Matsushita S. Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: retrospective longitudinal analysis.<br \/>\n<em><strong>Journal of Acquired Immune Deficiency Syndromes<\/strong><\/em>, 78(2):239-247, doi: 10.1097\/QAI.0000000000001662, 2018.<\/li>\n<\/ul>\n<h4>2017\u5e74<\/h4>\n<ul>\n<li><u>Satou Y<\/u>, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y,<br \/>\nMiyazato P,<br \/>\nIslam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K. Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.<br \/>\n<em><strong>Scientific Reports<\/strong><\/em>, 7(1):6913, doi: 10.1038\/s41598-017-07307-4, 2017.<\/li>\n<\/ul>\n<h4>2016\u5e74<\/h4>\n<ul>\n<li>Miyazato P, Katsuya H,<br \/>\nFukuda A, Uchiyama Y, Matsuo M, Tokunaga M, Hino S , Nakao M, <span class=\"auto-style1\">Satou Y<\/span>. Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome. <em><strong>Scientific Reports<\/strong><\/em>, 6:28324, doi: 10.1038\/srep28324, 2016.<\/li>\n<li>Miyazato P, Matsuo M, Katsuya H, <span class=\"auto-style1\">Satou Y<\/span>. Transcriptional and Epigenetic Regulatory Mechanisms affecting HTLV-1 provirus.<em><strong> Viruses, <\/strong><\/em>8(6):171, doi: 10.3390\/v8060171, 2016.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M,<br \/>\nFukuda A, Nosaka K, Watanabe T, Rowan A, Nakao M, Bangham C. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. <em><strong>Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em>, 113(11):3054-9, doi: 10.1073\/pnas.1423199113, 2016.<br \/>\n<strong>[<a class=\"blank\" style=\"text-decoration: none;\" href=\"http:\/\/ewww.kumamoto-u.ac.jp\/en\/news\/230\/\" target=\"_blank\" rel=\"noopener\">\u718a\u5927HP<\/a>][<a class=\"blank\" style=\"text-decoration: none;\" href=\"https:\/\/www.eurekalert.org\/pub_releases_ml\/2016-06\/ku-g060816.php\" target=\"_blank\" rel=\"noopener\">EurekAlert!HP<\/a>][<a class=\"blank\" style=\"text-decoration: none;\" href=\"http:\/\/htlv.umin.jp\/nl\/26929370.html\" target=\"_blank\" rel=\"noopener\">HTLV-1\u5b66\u4f1a<\/a>]<br \/>\n<\/strong><\/li>\n<\/ul>\n<h4>2014\u5e74<\/h4>\n<ul>\n<li>Zhao T, <span class=\"auto-style1\">Satou Y<\/span>, Matsuoka M. Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice. <em><strong>Archives of Virology<\/strong><\/em>. 159(7):1849-56, doi: 10.1007\/s00705-014-2099-y, 2014.<\/li>\n<\/ul>\n<h4>2013\u5e74<\/h4>\n<ul>\n<li>Sato K, Misawa N, Iwami S, <span class=\"auto-style1\">Satou Y<\/span>, Matsuoka M, Ishizaka Y, Ito M, Aihara K, Dong Sung An and Koyanagi Y. HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo. <em><strong>PLoS Pathogens,<\/strong><\/em> 9(12):e1003812, doi: 10.1371\/journal.ppat.1003812, 2013.<\/li>\n<li>Nanae Yamamoto-Taguchi, <span class=\"auto-style1\">Yorifumi Satou<\/span>, Paola Miyazato, Koichi Ohshima, Masanori Nakagawa, Koko Katagiri, Tatsuo Kinashi, Masao Matsuoka.HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. <em><strong>PLoS Pathog.<\/strong><\/em>, 9(9):e1003630, doi: 10.1371\/journal.ppat.1003630, 2013.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Matsuoka M. Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1.<em><strong>Reviews in Medical Virology<\/strong><\/em>, 10:885, doi: 10.3389\/fmicb.2019.00885, 2013.<\/li>\n<\/ul>\n<h4>2012\u5e74<\/h4>\n<ul>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, Matsuoka M. HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. <em><strong>Retrovirology<\/strong><\/em>, 9:46, doi: 10.1186\/1742-4690-9-46, 2012.<\/li>\n<li>Sugata K,<span class=\"auto-style1\"> Satou Y<\/span>, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, and Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines, <em><strong>Blood<\/strong><\/em>, 119(2):434-44, doi: 10.1182\/blood-2011-05-357459, 2012.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Matsuoka M. Molecular and cellular mechanism of leukemogenesis of ATL; emergent evidence of significant role of HBZ in HTLV-1-induced pathogenesis. <em><strong>Leukemia Research and Treatment<\/strong><\/em>, 2012:213653, doi: 10.1155\/2012\/213653, 2012.<\/li>\n<\/ul>\n<h4>2011\u5e74<\/h4>\n<ul>\n<li>Zhao T, <span class=\"auto-style1\">Satou Y<\/span>, Sugata K, Miyazato P, Green PL, Imamura T, and Matsuoka M. HTLV-1 bZIP factor enhances TGF-\u03b2 signaling through p300 coactivator. <em><strong>Blood<\/strong><\/em>, 118: 118(7):1865-76, doi: 10.1182\/blood-2010-12-326199, 2011.<\/li>\n<li>Shimizu-Kohno K, <span class=\"auto-style1\">Satou Y<\/span>, Arakawa F, Kiyasu J, Kimura Y, Niino D, Sugita Y, Ishikawa F, Matsuoka M, Ohshima K. Detection of human T-cell leukemia virus type 1 by means of HBZ in situ hybridization in formalin-fixed and paraffin-embedded tissues. <em><strong>Cancer Science<\/strong><\/em>, 102(7):1432-6, doi: 10.1111\/j.1349-7006.2011.01946.x, 2011.<\/li>\n<li>Sato K, Misawa N, Nie C, <span class=\"auto-style1\">Satou Y<\/span>, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, and Koyanagi Y. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. <em><strong>Blood<\/strong><\/em>, 117(21):5663-73, doi: 10.1182\/blood-2010-09-305979, 2011.<\/li>\n<li>Hagiya K, Yasunaga J, <span class=\"auto-style1\">Satou Y<\/span>, Oshima K and Matsuoka M. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. <em><strong>Retrovirology<\/strong><\/em>, 8:19, doi: 10.1186\/1742-4690-8-19, 2011.<\/li>\n<li><span class=\"auto-style1\">Satou Y,<\/span> Yasunaga J, Zhao T, Yoshida M, <span class=\"auto-style1\">Miyazato P<\/span>, Takai K, Shimizu K, Ohshima K, Green P, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M, HTLV-1 bZIP Factor Induces T-cell Lymphoma and Systemic Inflammation In Vivo.<em><strong>PLoS Pathogens<\/strong><\/em>, 7(2):e1001274, doi: 10.1371\/journal.ppat.1001274, 2011.<\/li>\n<\/ul>\n<h4>2010\u5e74\u4ee5\u524d<\/h4>\n<ul>\n<li><span class=\"auto-style1\">Satou Y<\/span> and Matsuoka M. HTLV-1 and the host immune system: How the virus disrupts immune regulation, leading to HTLV-1 associated diseases. <em><strong>Journal of Clinical and Experimental Hematopathology<\/strong><\/em>, 50(1):1-8, doi: 10.3960\/jslrt.50.1, 2010.<\/li>\n<li>Fan J, Ma G, Nosaka K, Tanabe J, <span class=\"auto-style1\">Satou Y<\/span>, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M. APOBEC3G Generates Nonsense Mutations in HTLV-1 Proviral Genomes In Vivo. <em><strong>Journal of Virology<\/strong><\/em>, 84(14):7278-87, doi: 10.1128\/JVI.02239-09, 2010.<\/li>\n<li>Saito M, Matsuzaki T, <span class=\"auto-style1\">Satou Y<\/span>, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y. In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). <em><strong>Retrovirology<\/strong><\/em>, 6:19, doi: 10.1186\/1742-4690-6-19, 2009.<\/li>\n<li>Zhao T, Yasunaga J, <span class=\"auto-style1\">Satou Y<\/span>, Nakao M, Takahashi M, Fujii M, Matsuoka M. Human T-cell Leukemia virus type 1 bZIP factor selectively suppresses classical pathway of NF-kB. <em><strong>Blood<\/strong><\/em>, 113(12):2755-64, doi: 10.1182\/blood-2008-06-161729, 2009.<\/li>\n<li>Yoshida M, <span class=\"auto-style1\">Satou Y<\/span>, Yasunaga JI, Fujisawa JI, Matsuoka M. Transcriptional control of spliced and unspliced HTLV-1 bZIP factor gene. <em><strong>Journal of Virology<\/strong><\/em>, 86(2):107-12, doi: 10.1532\/IJH97.07103, 2008.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Matsuoka M. Implication of the HTLV-I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia. <em><strong>International Journal of hematology<\/strong><\/em>, 107-12, doi: 10.1532\/IJH97.07103, 2007.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Yasunaga JI, Yoshida M, Matsuoka M. HTLV- I bZIP factor gene mRNA supports proliferation of adult T-cell leukemia cells. <em><strong>Proceedings of the National Academy of Sciences of the United States of America<\/strong><\/em>, 113(12):2755-64, doi: 10.1182\/blood-2008-06-161729, 2006.<\/li>\n<li>Doi K, Wu X, Taniguchi Y, Yasunaga JI,<span class=\"auto-style1\"> Satou Y<\/span>, Okayama A, Nosaka K, Matsuoka M. Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states. <em><strong>Blood<\/strong><\/em>, 106(3):1048-5, doi: 10.1182\/blood-2004-11-4350, 2005.<\/li>\n<li>Yasunaga JI, Taniguchi Y, Nosaka K, Yoshida M, <span class=\"auto-style1\">Satou Y<\/span>, Sakai T, Mitsuya H, Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. <em><strong>Cancer Research<\/strong><\/em>, 64(17):6002-9, doi: 10.1158\/0008-5472.CAN-04-1422, 2004.<\/li>\n<li><span class=\"auto-style1\">Satou Y<\/span>, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both <span style=\"font-style: italic;\">in vivo<\/span> and <span style=\"font-style: italic;\">in vitro.<\/span> <em><strong>Leukemia<\/strong><\/em>, 18(8):1357-63, doi: 10.1038\/sj.leu.2403400, 2004.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"\u767a\u8868\u8ad6\u6587 \u5b66\u4f1a\u767a\u8868 \u53d7\u8cde\u6b74 \u904e\u53bb\u306e\u767a\u8868\u8ad6\u2f42 2019\u5e74 Miyazato P, Matsuo M, Tan BJY, Tokunaga M, Katsuya H, Islam S, Ito J, Murakawa Y, &#8230; <a class=\"view-article\" href=\"https:\/\/kumamoto-u-jrchri.jp\/satou\/achievements\/old_thesis\/\">View Article<\/a>","protected":false},"author":1,"featured_media":0,"parent":15,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/pages\/472"}],"collection":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/comments?post=472"}],"version-history":[{"count":3,"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/pages\/472\/revisions"}],"predecessor-version":[{"id":475,"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/pages\/472\/revisions\/475"}],"up":[{"embeddable":true,"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/pages\/15"}],"wp:attachment":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/media?parent=472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}