{"id":69,"date":"2022-04-26T14:05:59","date_gmt":"2022-04-26T05:05:59","guid":{"rendered":"https:\/\/kumamoto-u-jrchri.jp\/satou\/?post_type=topics&#038;p=69"},"modified":"2022-05-13T17:03:13","modified_gmt":"2022-05-13T08:03:13","slug":"htlv-1%e6%84%9f%e6%9f%93%e3%81%af%e9%81%8e%e5%89%b0%e3%81%aat%e7%b4%b0%e8%83%9e%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%97%e3%80%81%e6%84%9f%e6%9f%93","status":"publish","type":"topics","link":"https:\/\/kumamoto-u-jrchri.jp\/satou\/news\/topics\/htlv-1%e6%84%9f%e6%9f%93%e3%81%af%e9%81%8e%e5%89%b0%e3%81%aat%e7%b4%b0%e8%83%9e%e3%81%ae%e6%b4%bb%e6%80%a7%e5%8c%96%e3%82%92%e5%bc%95%e3%81%8d%e8%b5%b7%e3%81%93%e3%81%97%e3%80%81%e6%84%9f%e6%9f%93\/","title":{"rendered":"HTLV-1\u611f\u67d3\u306f\u904e\u5270\u306aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u611f\u67d3\u7d30\u80de\u306e\u304c\u3093\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002"},"content":{"rendered":"<h4>\u30dd\u30a4\u30f3\u30c8<\/h4>\n<ul>\n<li>\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b\uff08HTLV-1\uff09\u304cCD4<sup>+<\/sup>T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u6a5f\u5e8f\u3092\u5229\u7528\u3057\u3001\u3055\u3089\u306b\u904e\u5270\u306aCD4<sup>+<\/sup>T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u3066\u3001\u304c\u3093\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>HTLV-1\u306b\u611f\u67d3\u3057\u305fCD4<sup>+<\/sup>T\u7d30\u80de\u306f\u3001\u904e\u5270\u306a\u6d3b\u6027\u5316\u306b\u4f34\u3063\u3066\u3001\u672c\u6765T\u7d30\u80de\u306e\u3054\u304f\u4e00\u90e8\u3067\u3057\u304b\u767a\u73fe\u3057\u306a\u3044HLA\u30af\u30e9\u30b9\u2161\u3068\u3088\u3070\u308c\u308b\u5206\u5b50\u3092\u767a\u73fe\u3057\u3066\u3001\u5bbf\u4e3b\u514d\u75ab\u304b\u3089\u9003\u907f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/li>\n<li>\u3053\u308c\u3089\u306e\u767a\u898b\u306f\u3001HTLV-1\u306b\u3088\u308b\u611f\u67d3\u7d30\u80de\u304c\u3093\u5316\u306e\u672c\u614b\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u77e5\u898b\u3067\u3042\u308a\u3001\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3084\u6cbb\u7642\u6a19\u7684\u306e\u5275\u51fa\u306b\u5411\u3051\u5927\u304d\u304f\u524d\u9032\u3059\u308b\u7814\u7a76\u6210\u679c\u3067\u3059\u3002<\/li>\n<\/ul>\n<h4>\u7814\u7a76\u6982\u8981<\/h4>\n<p>\u3000\u79c1\u9054\u306e\u8eab\u4f53\u306f\u3001\u75c5\u539f\u4f53\u3084\u304c\u3093\u7d30\u80de\u306b\u5bfe\u3057\u3066\u3001\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u305d\u308c\u3089\u3092\u6392\u9664\u3059\u308b\u3053\u3068\u3067\u75c5\u6c17\u3092\u672a\u7136\u306b\u9632\u3044\u3067\u5065\u5eb7\u306a\u72b6\u614b\u3092\u4fdd\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u969b\u306b\u3001\u767d\u8840\u7403\u306e\u4e00\u7a2e\u3067\u3042\u308bCD4<sup>+<\/sup>T\u7d30\u80de\u306f\u3001\u75c5\u539f\u4f53\u3084\u304c\u3093\u7d30\u80de\u306e\u6297\u539f\u3092\u8a8d\u8b58\u3057\u3066\u30a8\u30d5\u30a7\u30af\u30bf\u30fcCD4<sup>+<\/sup>T\u7d30\u80de\u3068\u3057\u3066\u6d3b\u6027\u5316\u30fb\u5897\u6b96\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u514d\u75ab\u5fdc\u7b54\u306e\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u5fdc\u7b54\u6d3b\u6027\u5316\u306e\u5f79\u5272\u3092\u7d42\u3048\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fcCD4<sup>+<\/sup>T\u7d30\u80de\u306f\u3001\u7d30\u80de\u6b7b\u306b\u3088\u308a\u6d88\u5931\u3059\u308b\u304b\u3001\u30e1\u30e2\u30ea\u30fcCD4<sup>+<\/sup>T\u7d30\u80de\u3068\u306a\u3063\u3066\u3001\u518d\u5ea6\u51fa\u73fe\u3059\u308b\u75c5\u539f\u4f53\u3084\u304c\u3093\u7d30\u80de\u306b\u5099\u3048\u3066\u751f\u4f53\u5185\u3092\u5faa\u74b0\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4e00\u9023\u306e\u6d41\u308c\u304c\u300c\u6b63\u5e38\u306aCD4<sup>+<\/sup>T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3068\u5206\u5316\u300d\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u56f31\uff09\u3002<\/p>\n<div class=\"topic_img_box\"><img src=\"\/satou\/wp\/wp-content\/uploads\/2022\/05\/topics1_img01.png\" alt=\"\" \/><\/div>\n<div 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class=\"topic_img_box\"><img src=\"\/satou\/wp\/wp-content\/uploads\/2022\/05\/topics1_img02.png\" alt=\"\" \/><\/div>\n<div class=\"topic_img_suggest\">\u56f32\uff1a\u5065\u5e38\u8005\u3068HTLV-1\u611f\u67d3\u8005\u306e\u672b\u68a2\u8840\u7d30\u80de\u3092\u7528\u3044\u305f\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc<\/div>\n<p>\u3000\u6b21\u306b\u3001\u53d6\u5f97\u3057\u305f\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30c7\u30fc\u30bf\u3092\u5148\u7aef\u7684\u306a\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u624b\u6cd5\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u69d8\u3005\u306a\u767a\u304c\u3093\u30b9\u30c6\u30c3\u30d7\u306e\u304c\u3093\u7d30\u80de\uff08ATL\u7d30\u80de\uff09\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u304c\u3093\u5316\u306e\u904e\u7a0b\u3067\u7d30\u80de\u306b\u751f\u3058\u308b\u5909\u5316\u306e\u8a73\u7d30\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001HTLV-1\u306f\u5bbf\u4e3b\u306eCD4<sup>+<\/sup>T\u7d30\u80de\u304c\u672c\u6765\u6301\u3064T\u7d30\u80de\u6d3b\u6027\u5316\u306e\u4ed5\u7d44\u307f\u3092\u5229\u7528\u3057\u3066\u3001HTLV-1\u306b\u611f\u67d3\u3057\u305fCD4<sup>+<\/sup>T\u7d30\u80de\u3092\u5897\u6b96\u30fb\u751f\u5b58\u3078\u3068\u8a98\u5c0e\u3057\u3001\u305d\u306e\u6d3b\u6027\u5316\u304c\u66f4\u306b\u904e\u5270\u306b\u8d77\u3053\u3063\u305f\u7d50\u679c\u3001HTLV-1\u306b\u611f\u67d3\u3057\u305fCD4<sup>+<\/sup>T\u7d30\u80de\u304c\u304c\u3093\u5316\uff08ATL\u7d30\u80de\u5316\uff09\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08\u56f33\uff09\u3002<\/p>\n<div class=\"topic_img_box\"><img src=\"\/satou\/wp\/wp-content\/uploads\/2022\/05\/topics1_img03.png\" alt=\"\" \/><\/div>\n<div class=\"topic_img_suggest\">\u56f33\uff1aHTLV-1\u306b\u3088\u308b\u304c\u3093\u5316\u904e\u7a0b\u3092\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u30c7\u30fc\u30bf\u4e0a\u3067\u518d\u69cb\u7bc9<\/div>\n<p>\u3000\u3055\u3089\u306b\u3001HTLV-1\u306b\u611f\u67d3\u3057\u305fCD4<sup>+<\/sup>T\u7d30\u80de\u306f\u3001\u904e\u5270\u306a\u6d3b\u6027\u5316\u306b\u4f34\u3044\u3001\u672c\u6765T\u7d30\u80de\u306e\u3054\u304f\u4e00\u90e8\u3067\u3057\u304b\u51fa\u3066\u3053\u306a\u3044HLA\u30af\u30e9\u30b9\u2161<sup>\u203b7<\/sup>\u3068\u3044\u308f\u308c\u308b\u5206\u5b50\u3092\u7d30\u80de\u8868\u9762\u306b\u51fa\u3059\u3053\u3068\u3067\u3001\u6297\u539f\u63d0\u793a\u7d30\u80de\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001ATL\u7d30\u80de\u306fT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u523a\u6fc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u5171\u523a\u6fc0\u5206\u5b50\uff08CD80\/CD86\uff09\u3092\u767a\u73fe\u3057\u306a\u3044\u305f\u3081\u3001ATL\u7d30\u80de\u306b\u3088\u308aHTLV-1\u90e8\u5206\u30da\u30d7\u30c1\u30c9\u306e\u6297\u539f\u523a\u6fc0\u3092\u53d7\u3051\u305fHTLV\u7279\u7570\u7684CD4<sup>+<\/sup>T\u7d30\u80de\u306f\u3001\u514d\u75ab\u5bdb\u5bb9\u306b\u95a2\u308f\u308b\u5206\u5b50(EGR\u3084CBL-B\u306a\u3069)\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3067\u4e0d\u5fdc\u7b54\u6027\u72b6\u614b\uff08T\u7d30\u80de\u30a2\u30ca\u30b8\u30fc\uff09\u306b\u9665\u308a\u3001\u5bbf\u4e3b\u306e\u6297HTLV-1\u514d\u75ab\u3092\u8a98\u5c0e\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\uff08\u56f34\uff09\u3002<\/p>\n<div class=\"topic_img_box\"><img src=\"\/satou\/wp\/wp-content\/uploads\/2022\/05\/topics1_img04.png\" alt=\"\" \/><\/div>\n<div 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class=\"topic_ronbun\">\n<dt>\u8ad6\u6587\u540d\uff1a<\/dt>\n<dd>HTLV-1 infection promotes excessive T-cell activation and malignant transformation into adult T-cell leukemia\/lymphoma<\/dd>\n<dt>\u8457\u8005\uff1a<\/dt>\n<dd>Benjy Jek Yang Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono and Yorifumi Satou<\/dd>\n<dt>\u63b2\u8f09\u8a8c\uff1a<\/dt>\n<dd>Journal of Clinical Investigation 2021<\/dd>\n<\/dl>\n","protected":false},"featured_media":0,"template":"","acf":[],"_links":{"self":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/topics\/69"}],"collection":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/topics"}],"about":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/types\/topics"}],"wp:attachment":[{"href":"https:\/\/kumamoto-u-jrchri.jp\/satou\/wp-json\/wp\/v2\/media?parent=69"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}