大学院生業績

2008-

赤星　智寛　（大学院博士課程2011年度修了）

■論文発表
2016	Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi, HIV-1 control by NK cells via reduced interaction between KIR2DL2 and HLA-C*12:02/C*14:03, Cell Reports 17:2210-2220, 2016
	Xiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schonbach, Nozomi Kuse, Victor Appay, George F. Gao, Shinichi Oka, and Masafumi Takiguchi, Effects of a single escape mutation on T cell and HIV-1 co-adaptation, Cell Reports, 15:2279-2291, 2016
	Giang Van Tran,* Takayuki Chikata,* Jonathan M. Carson, Hayato Murakoshi, Dung Hoai Nguyen, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Keiko Sakai, Sachiko Sakai, Kyle Cobarrubias, Shinichi Oka, Zabrina L. Brumme, Kinh Van Nguyen, and Masafumi Takiguchi (*Equal contribution), A strong association of HLA-associated Pol and Gag mutations with clinical parameters in HIV-1 subtype A/E infection, AIDS 30:681-689, 2016
2015	Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes, J. Virol. 89:5330-5339, 2015
2014	Nozomi Kuse, Tomohiro Akahoshi, Hiroyuki Gatanaga, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Selection of TI8-8V Mutant Associated with Long-Term Control of HIV-1 by Cross-Reactive HLA-B*51:01-restricted Cytotoxic T Cells, J. Immunol. 193:4814-4822, 2014
2013	Yuichi Yagita*, Nozomi Kuse*, Kimiko Kuroki*, Hiroyuki Gatanaga, Jonathan M. Carlson, Takayuki Chikata, Zabrina L. Brumme, Hayato Murakoshi, Tomohiro Akahoshi, Nico Pfeifer, Simon Mallal, Mina John, Toyoyuki Ose, Haruki Matsubara, Ryo Kanda, Yuko Fukunaga, Kazutaka Honda, Yuka Kawashima, Yasuo Ariumi, Shinichi Oka, Katsumi Maenaka, and Masafumi Takiguchi (*Equal contribution), Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity, J. Virol. 87:2253-2263, 2013
2012	Philippa C. Matthews*, Madoka Koyanagi*, Henrik N. Kloverpris*, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung’u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Soren Buus, Masafumi Takiguchi, and Philip J. R. Goulder (*Equal contribution), Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope. J. Virol. 86:12643-12654, 2012
	Masao Hashimoto, Tomohiro Akahoshi, Hayato Murakoshi, Naoki Ishizuka, Shinichi Oka, and Masafumi Takiguchi, CTL recognition of HIV-1-infected cells via cross-recognition of multiple overlapping peptides from a single 11-mer Pol sequence Eur. J. Immunol. 42:2621-2631,2012
	Tomohiro Akahoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific CTLs recognizing wild-type and/or escape mutant epitopes. J. Virol. 86(4):1971-1981, 2012
2010	Yuka Kawashima*, Nozomi Kuse*, Hiroyuki Gatanaga*, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi, Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101. J. Virol. 84:7151-7160, 2010 (* equal contribution)
2009	Hayato Murakoshi, Mitsutaka Kitano, Tomohiro Akahoshi, Yuka Kawashima, Sachi Dohki, Shinichi Oka and Masafumi Takiguchi, Identification and characterization of 2 HIV-1 Gag immunodominant epitopes restricted by Asian HLA allele HLA-B*4801, Human Immunol. 70:170-174, 2009
2008	Mitsutaka Kitano, Naoki Kobayashi, Yuka Kawashima, Tomohiro Akahoshi, Kiyoshi Nokihara, Shinichi Oka and Masafumi Takighuchi, Identification and characterization of HLA-B*5401-restricted HIV-1-Nef and Pol-specific CTL epitopes, Microbe and Infection, 10:764-772, 2008

■学会発表
2016	Tomohiro Akahoshi, Masao Hashimoto, Takayuki Chikata, Hayato Murakoshi, Nozomi Kuse, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Co-evolution between HIV-1 escape mutant and HIV-1-specific T cells, 2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar (Kumamoto, Japan), October 31 - November 2, 2016
2015	Tomohiro Akahoshi, Madoka Koyanagi, Hayato Murakoshi, Nozomi Kuse, and Masafumi Takiguchi, An escape mutation selected by HIV-1-specific CTLs generates a novel CTL epitope, 第44回日本免疫学会学術集会（札幌）, 2015年11月18-20日
	Tomohiro Akahoshi, Madoka Koyanagi, Hayato Murakoshi, Nozomi Kuse, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HIV-1-specific CD8+ T cells restricted by the most frequent HLA haplotype in Japan may shape viral polymorphism at RT135, 16th KUMAMOTO AIDS Seminar (Kumamoto, Japan) October 7-9, 2015
2014	Tomohiro Akahoshi, Hayato Murakoshi, and Masafumi Takiguchi, Conflicting viral selection by HIV-1-specific CTLs, 第43回日本免疫学会学術集会（京都）, 2014年12月10-12日
	Tomohiro Akahoshi, Masao Hashimoto, Hayato Murakoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Conflicting viral selection by HIV-1-specific CTLs, 15th KUMAMOTO AIDS Seminar (Kumamoto, Japan) October 1-3, 2014
2013	Tomohiro Akahoshi, Hayato Murakoshi and Masafumi Takiguchi, Reversion of a CTL escape mutation byescape mutant-specific CTLs, 第42回日本免疫学会学術集会（千葉）, 2013年12月11-13日
	Tomohiro Akahoshi, Masao Hashimoto, Hayato Murakoshi, Takayuki Chikata, Shinichi Oka and Masafumi Takiguchi, Reversion of a CTL escape mutation by escape mutant-specific CTLs, 14th KUMAMOTO AIDS Seminar (Kumamoto, Japan) October 29-31, 2013
2012	Tomohiro Akahoshi, Masao Hashimoto, Hayato Murakoshi, and Masafumi Takiguchi, CTL recognition of HIV-1-infected cells via cross-recognition of multiple overlapping peptides from a single 11-mer Pol sequence, 第41回日本免疫学会学術集会（神戸）, 2012年12月5-7日
2011	赤星 智寛, 近田 貴敬, 田村 美子, 潟永 博之, 岡 慎一, 滝口 雅文, HIV-1 特異的細胞傷害性T 細胞(CTL)による逃避変異の選択と蓄積の機序の解明, 第25回日本エイズ学会学術集会・総会（東京）, 2011年11月30日-12月2日
	Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Role of cross-reactive CTLs in selection of HIV-1escape mutant, 12th KUMAMOTO AIDS Seminar-GCOE Joint International Symposium (Kumamoto, Japan) October19-21, 2011
	AIDS Vaccine 2011 Scholarship 受賞 Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HIV-1-specific cytotoxic T lymphocytes cross-recognizing an escape mutation at early phase of HIV-1 infection, AIDS Vaccine 2011 (Bangkok, Thailand) September12-15, 2011
	Bill & Melinda Gates Foundation Scholarship受賞 Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Antiviral activities of HIV-1-specific T lymphocytes cross-recognizing an escape mutation, Keystone symposia−Protection from HIV: Targeted Intervention Strategies (Whistler, Canada) March21-25, 2011
2010	赤星 智寛, 滝口 雅文, 免疫逃避変異と交差反応性を有するHIV-1特異的細胞傷害性T細胞（CTL）の解析, 第58回日本ウイルス学会学術集会（徳島）2010年11月6-9日
	Tomohiro Akahoshi, Shinichi Oka, and Masafumi Takiguchi ,HIV-1-specific cytotoxic T lymphocytes having cross-recognition for escape mutation, 11th Kumamoto AIDS Seminar- GCOE joint International Symposium (Kumamoto, Japan) Oct. 6-8, 2010

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