院生業績

大学院生業績

2010-

近田　貴敬 （大学院博士課程2014年6月修了）

■論文発表
2016	Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi, HIV-1 control by NK cells via reduced interaction between KIR2DL2 and HLA-C12:02/C14:03, Cell Reports 17:2210-2220, 2016
2016	Giang Van Tran,* Takayuki Chikata,* Jonathan M. Carson, Hayato Murakoshi, Dung Hoai Nguyen, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Keiko Sakai, Sachiko Sakai, Kyle Cobarrubias, Shinichi Oka, Zabrina L. Brumme, Kinh Van Nguyen, and Masafumi Takiguchi (*Equal contribution), A strong association of HLA-associated Pol and Gag mutations with clinical parameters in HIV-1 subtype A/E infection, AIDS 30:681-689, 2016
2015	Keiko Sakai, Takayuki Chikata, Zabrina L. Brumme, Chanson J. Brumme, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals, Retrovirology 12:98, 2015
	Nozomi Kuse, Mohammad Arif Rahman, Hayato Murakoshi, Giang Van Tran, Takayuki Chikata, Madoka Koyanagi, Kinh Van Nguyen, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections (Equal contribution), J. Virol. 89:7363-7372, 2015
	Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes, J. Virol. 89:5330-5339, 2015
2014	Takayuki Chikata, Jonathan M. Carlson, Yoshiko Tamura, Mohamed Ali Borghan, Takuya Naruto, Masao Hashimoto, Hayato Murakoshi, Anh Q. Le, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, Zabrina L. Brumme, and Masafumi Takiguchi, Host-specific adaptation of HIV-1 subtype B in the Japanese population, J.Virol. 88:4764-4775, 2014
2013	Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Identification of cross-clade CTL epitopes in HIV-1 clade A/E-infected individuals by using the clade B overlapping peptides(*Equal contribution), Microbes and Infection, 15:874-886, 2013
	Hiroyuki Gatanaga, Hayato Murakoshi, Atsuko Hachiya, Tsunefusa Hayashida, Takayuki Chikata, Hirotaka Ode, Kiyoto Tsuchiya, Wataru Sugiura, Masafumi Takiguchi, and Shinichi Oka, Naturally selected rilpivirine-resistant HIV-1 variants by host cellular immunity, Clinical Infectious Disease, 57:1051-1055, 2013
	Kristin Ladell, Masao Hashimoto, Maria Candela Iglesias, Pascal G. Wilmann, James E. McLaren, Stephanie Gras, Takayuki Chikata, Nozomi Kuse, Solene Fastenackels, Emma Gostick, John S. Bridgeman, Vanessa Venturi, Zaina Ait Arkoub, Henri Agut, David J. van Bockel, Jorge R. Almeida, Daniel C. Douek, Laurence Meyer, Alain Venet, Masafumi Takiguchi, Jamie Rossjohn, David A. Price and Victor Appay (,* Equal contribution), A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity. 38:425-436, 2013
	Yuichi Yagita, Nozomi Kuse, Kimiko Kuroki, Hiroyuki Gatanaga, Jonathan M. Carlson, Takayuki Chikata, Zabrina L. Brumme, Hayato Murakoshi, Tomohiro Akahoshi, Nico Pfeifer, Simon Mallal, Mina John, Toyoyuki Ose, Haruki Matsubara, Ryo Kanda, Yuko Fukunaga, Kazutaka Honda, Yuka Kawashima, Yasuo Ariumi, Shinichi Oka, Katsumi Maenaka, and Masafumi Takiguchi (Equal contribution), Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity, J. Virol. 87:2253-63, 2013
2012	Xiaoming Sun, Masumichi Saito, Yoshinori Sato, Takayuki Chikata, Takuya Naruto, Tatsuhiko Ozawa, Eiji Kobayashi, Hiroyuki Kishi, Atsushi Muraguchi, and Masafumi Takiguchi, Unbiased analysis of TCRα/β chains at the single-cell level in human CD8+ T-cell subsets. PLoS ONE. 7(7):e40386, 2012.
2012	Tomohiro Akahoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific CTLs recognizing wild-type and/or escape mutant epitopes. J. Virol. 86(4):1971-1981, 2012
2011	Takuya Naruto, Hayato Murakoshi, Takayuki Chikata, Madoka Koyanagi, Yuka Kawashima, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Selection of HLA-B57-associated Gag A146P mutant by HLA-B*48:01-resticted Gag140-147-specific CTLs in chronically HIV-1-infected Japanese. Microbes and Infection 13: 766-770, 2011
2011	Kazutaka Honda, Nan Zheng, Hayato Murakoshi, Masao Hashimoto, Keiko Sakai, Mohamed Ali Borghan, Takayuki Chikata, Madoka Koyanagi, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes carrying strong ability to suppress HIV-1 replication. Eur. J. Immunol.　41:97-106, 2011
2010	Hirokazu Koizumi, Masao Hashimoto, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Different in vivo effects of HIV-1 immunodominant epitope-specific CTLs on selection of escape mutant viruses. J. Virol. 84: 5508-5519, 2010 (* equal contribution)

■学会発表
2016	Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Madoka Koyanagi, Sachiko Sakai, Keiko Sakai, Kinh Van Nguyen, and Masafumi Takiguchi, Contribution of HLA class I alleles to clinical outcome in HIV-1 subtype A/E infected Vietnamese individuals, 2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar (Kumamoto, Japan), October 31 - November 2, 2016
	Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Keiko Sakai, Kinh Van Nguyen, and Masafumi Takiguchi, Contribution of HLA class I alleles to clinical outcome in HIV-1 subtype A/E infected Vietnamese individuals, 第64回日本ウイルス学会学術集会（札幌）, 2016年10月23-25日
2015	近田貴敬, Giang Van Tran, Jonathan Carlson, 村越勇人, Dung Hoai Nguyen, 田村美子, 赤星智寛, 久世望, 阪井恵子, 小柳円, 酒井幸子, Kyle Cobarrubias, 岡慎一, Zabrina Brumme, Kinh Van Nguyen, 滝口雅文, ベトナム人慢性HIV-1感染者におけるHIV-1特異的細胞傷害性T細胞の網羅的解析, 第29回日本エイズ学会学術集会・総会（東京）, 2015年11月30-12月1日
	Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, and Masafumi Takiguchi, The impact of one amino-acid substitution outside the binding groove between HLA-C*03 subtypes in binding of HIV-1 peptide to the HLA molecules, 第44回日本免疫学会学術集会（札幌）, 2015年11月18-20日
2014	Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Shinichi Oka, and Masafumi Takiguchi, The impact of amino-acid substitution at a position outside the peptide binding groove of HLA-C subtypes in HIV-1-specific T cell recognition, 15th KUMAMOTO AIDS Seminar (Kumamoto, Japan) October 1-3, 2014
	近田貴敬, Jonathan M Carlson, 田村美子, Mohamed Ali Borghan, 成戸卓也, 端本昌夫, 村越勇人, Anh Q. Le, Simon Mallal, Mina John, 潟永博之, 岡慎一, Zabrina L Brumme, 滝口雅文, 日本人HIV-1慢性感染者におけるHLAに関連したHIV-1多型の解析と非アジア人コホートとの比較解析, 第16回白馬シンポジウム（熊本）, 2014年6月13-14日
2013	近田貴敬, Jonathan M Carlson, 田村美子, Mohamed Ali Borghan, 成戸卓也, 端本昌夫, 村越勇人, Simon Mallal, Mina John, 潟永博之, 岡慎一, Zabrina L Brumme, 滝口雅文, 日本人と白人におけるHIV-1サブタイプBのHLA-Associated Polymorphismの比較解析, 第27回日本エイズ学会学術集会・総会（熊本）, 2013年11月20-22日
	Takayuki Chikata, Jonathan M Carlson, Yoshiko Tamura, Mohamed Ali Borghan, Takuya Naruto, Masao Hashimoto, Hayato Murakoshi, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, Zabrina L. Brumme and Masafumi Takiguchi, Host-specific adaptation of HIV-1 subtype B in the Japanese population, 14th KUMAMOTO AIDS Seminar (Kumamoto, Japan) October 29-31, 2013
	Takayuki Chikata, Jonathan M Carlson, Yoshiko Tamura, Mohamed Ali Borghan, Takuya Naruto, Masao Hashimoto, Hayato Murakoshi, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, Zabrina L. Brumme and Masafumi Takiguchi, HIV-1 polymorphisms associated with 4-digit HLA alleles in Japanese individuals chronically infected with the clade B virus, AIDS Vaccine 2013 (Barcelona, Spain) October 7-10, 2013
2012	近田貴敬, Jonathan M Carlson, 田村美子, Zabrina Brumme, 成戸卓也, 端本昌夫, Mohamed Ali Borghan, Mina John, Simon Mallal, 滝口雅文, 日本人慢性HIV-1感染者におけるHLA-Associated Polymorphismの解析, 第60回日本ウイルス学会学術集会（大阪）, 2012年11月13-15日
	Takayuki Chikata, Jonathan M Carlson, Yoshiko Tamura, Zabrina L. Brumme, Mohamed Ali　Borghan, Takuya Naruto, Masao Hashimoto, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-clade B-Infected Japanese Individuals: Analysis of Four-Digit HLA Allele Level, 13th KUMAMOTO AIDS Seminar-GCOE Joint International Symposium (Kumamoto, Japan) October24-26, 2012
	AIDS Vaccine 2012 Scholarship 受賞 Takayuki Chikata, Jonathan M Carlson, Yoshiko Tamura, Zabrina L. Brumme, Takuya Naruto, Masao Hashimoto, Mohamed Ali　Borghan, Simon Mallal, Mina John, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-Infected Japanese Cohort: Analysis of Four-Digit HLA Allele Level, AIDS Vaccine 2012 (Boston, USA) September 9-12, 2012
2011	Takayuki Chikata, Masao Hashimoto, Yoshiko Tamura, Takuya Naruto, Mohamed Ali　Borghan, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-Infected Japanese Cohort, 12th KUMAMOTO AIDS Seminar-GCOE Joint International Symposium (Kumamoto, Japan) October19-21, 2011
	The 59th Japanese society for virology Scholarship 受賞 Takayuki Chikata, Masao Hashimoto, Yoshiko Tamura, Takuya Naruto, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-Infected Japanese Cohort, IUMS 2011-XV International Congress of Virology (Sapporo, Japan) September11-16, 2011
	IAS 2011 International Scholarship 受賞 Takayuki Chikata, Masao Hashimoto, Yoshiko Tamura, Takuya Naruto, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-Infected Japanese Cohort, 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention (Rome, Italy) July17-20, 2011
	Takayuki Chikata, Masao Hashimoto, Yoshiko Tamura, Takuya Naruto, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1-Infected Japanese Cohort, Keystone symposia－HIV Evolution, Genomics and Pathogenesis (Whistler, Canada) March21-25, 2011
2010	近田貴敬, 端本昌夫, 成戸卓也, 田村美子, Mohamed Ali Borghan, 滝口雅文, 日本人HIV-1慢性感染者におけるHLA-Associated Polymorphismの解析, 第58回日本ウイルス学会学術集会（徳島）2010年11月6-9日
	Takayuki Chikata, Masao Hashimoto, Yoshiko Tamura, Takuya Naruto, Mohamed Ali Borghan, Sayaka Nagata, Mari Hasegawa, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi, HLA-Associated Viral Polymorphism in Chronically HIV-1 Infected Japanese Cohort, 11th Kumamoto AIDS Seminar- GCOE joint International Symposium (Kumamoto, Japan) October 6-8, 2010


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