院生業績

大学院生業績

2002-

藤原　守（大学院博士課程2007年度修了）

■論文発表
2014	Xiaoming Sun, Mamoru Fujiwara*, Yi Shi, Nozomi Kuse, Hiroyuki Gatanaga, Victor Appay, George F. Gao, Shinichi Oka, and Masafumi Takiguchi (* Equal contribution), Superimposed epitopes restricted by the same HLA molecule drive distinct HIV-specific CD8+ T cell repertoires. J. Immunol. In press
2010	Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi, Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B5101. J. Virol. 84:7151-7160, 2010 (* equal contribution)
2010	Hirokazu Koizumi, Masao Hashimoto, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Different in vivo effects of HIV-1 immunodominant epitope-specific CTLs on selection of escape mutant viruses. J. Virol. 84: 5508-5519, 2010 (* equal contribution)
2009	Nan Zheng, Mamoru Fujiwara, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress HIV-1 replication in HIV-1-infected CD4+ T cells and macrophages, J. Virol. 83: 7668-7677, 2009
	Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung’u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder (*equally contribution) Adaptation of HIV-1 to Human Leukocyte Antigen class I . Nature, 458: 641-645, 2009
	Hirokazu Koizumi, Tomomi Iwatani, Junko Tanuma, Mamoru Fujiwara, Taisuke Izumi, Shinichi Oka, and Masafumi Takiguchi, Escape mutation selected by Gag28-36-specific cytotoxic T cells in HLA-A*2402-positive HIV-1-infected donors, Microbe and Infection,11: 198-204, 2009
2008	Junko Tanuma, Mamoru Fujiwara, Katsuji Teruya, Saori Matsuoka, Hikaru Yamanaka, Hiroyuki Gatanaga, Natsuo Tachikawa, Yoshimi Kikuchi, Masafumi Takiguchi, and Shinichi Oka HLA-A*2402-restricted HIV-1-specific cytotoxic T lymphocytes and escape mutation after ART with structured treatment interruptions, Microbes and Infection, 10:689-698, 2008
2008	Mamoru Fujiwara, Junko Tanuma, Hirokazu Koizumi, Yuka Kawashima, Kazutaka Honda, Saori Mastuoka-Aizawa, Sachi Dohki, Shinichi Oka and Masafumi Takiguchi, Different Ability of Escape Mutant-Specific Cytotoxic T Cells to Suppress Replication of Escape Mutant and Wild-type HIV-1 in New Hosts, J. Virol.,82: 138-147, 2008
2007	Mamoru Fujiwara and Masafumi Takiguchi:HIV-1-Specific CTLs Effectively Suppress Replication of HIV-1 in HIV-1-infected Macrophages, Blood 109:4832-4838, 2007
2005	Mamoru Fujiwara, Hiroshi Takata, Shinichi Oka, Hiroko Tomiyama, and Masafumi Takiguchi: Patterns of cytokine production in HIV-1-specific human CD8+ T cells after stimulation with HIV-1-infected CD4+ T cells, J. Virol. 79: 12536-12543. 2005 [PDF]
2004	Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi: Cutting Edge: Epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTLs to suppress HIV-1 replication , J. Immunol 174: 36-40, 2005. [PDF]
	Takamasa Ueno, Mamoru Fujiwara, Hiroko Tomiyama, Masafumi Onodera, Masafumi Takiguchi(2004) Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific αβ TCR genes, Eur. J. Immunol., 34(12): 3379-3388
	Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi (2004) Functionally impaired HIV-specific CD8 T cells show high-affinity T cell receptor-ligand interactions. J. Immunol. 173: 5451-5457. [PDF] [Abstract(日本語)]
	Hiroshi Takata, Hiroko Tomiyama, Mamoru Fujiwara, Naoki Kobayashi, and Masafumi Takiguchi (2004) Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells. J. Immunol. 173: 2231-2235.
2003	Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi, Oka, Masafumi Takiguchi (2003) HLA class I-restricted recognition of an HIV-derived epitope peptide by a human T cell receptor α chain having a Vδ1 variable segment. European Journal of Immunology, 33: 2910-2916.

■学会発表
2007	藤原守、田沼順子、小泉寛和、川島夕佳、本田一貴、松岡佐織、岡慎一、滝口雅文(2007)HLA-A*2402拘束性HIV-1 Nef由来免疫ドミナントエピトープ領域のエスケープ変異に対する細胞傷害性T細胞の応答第55回日本ウイルス学会学術集会(札幌) 10月21日-23日
	Mamoru Fujiwara, Tanuma, J., Yuka Kawashima, Hirokazu Koizumi, Kazutaka Honda, Shinichi Oka and Masafumi Takiguchi, Responses of cytotoxic T cells to escape mutation of immunodominant HIV-1 Nef epitope, Keystone Symposia HIV Vaccines(Whistler, Canada) March 25-30, 2007
2006	藤原守、小泉寛和、本田一貴、岡慎一、滝口雅文(2006)Strong ability of HLA-A*2402-restricted Nef138-10-specific CTLs to suppress HIV-1 replication　第３６回日本免疫学会学術集会・総会（大阪）12月11日～12月13日
	M. Fujiwara, H. Koizumi, K. Honda, S. Oka, and M. Takiguchi, Strong suppression of HIV-1 replication by HLA-A*2402-restricted Nef138-10-specific CTLs, 7th AIDS Seminar in Kumamoto. (Kumamoto, Japan) September 21-22, 2006.
2005	藤原　守、高田比呂志、岡　慎一、滝口　雅文 (2005)　HIV-1特異的CD8<SUP>+</SUP>T細胞によるHIV-1感染CD4<SUP>+</SUP>T細胞認識とサイトカイン産生　第19回日本エイズ学会学術集会(熊本)12月1日～3日
	藤原　守、滝口　雅文 (2005) HIV-1感染初期における免疫誘導の解析：HIV-1感染マクロファージに対するHIV-1特異的CD8+T細胞応答第53回日本ウイルス学会学術集会(横浜)11月20日～22日
	Mamoru Fujiwara and Masafumi Takiguchi, Different cytokine production patterns in CD8+ T cells specific for the same and different HIV-1 epitopes, Keystone symposia HIV Pathogenesis (Keystone, Canada) April 9-15, 2005→学会の様子はこちら
2004	藤原守、富山宏子、岡慎一、滝口雅文 (2004) HLA-B*5101拘束性HIV-1特異的CTLのHIV-1増殖抑制能と病態進行への関与に関する解析第５２回日本ウイルス学会学術集会(横浜) ２００４年１１月２１日～２３日
	Mamoru Fujiwara, Hiroko Tomiyama, Shinichi Oka, and Masafumi Takiguchi, Epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTL to suppress HIV-1 replication: HLA-B*5101-restricted, HIV-1-specific cytotoxic T cells effectively suppress HIV-1 replication, 5th AIDS Seminar in Kumamoto. (Kumamoto, Japan) September 9-10, 2004.
	AIDS Vaccine 2004 International Conference(Lausanne, Switzerland) August 30- September 1, 2004 Travel Grant HLA-B*5101-restricted, HIV-1-specific cytotoxic T cells effectively suppress HIV-1 replication and control HIV-1 in long-term non-progressors and slow progressors→ 発表の様子はこちらから
2003	藤原守、冨山宏子、滝口雅文(2003) 同じ特異性を持つHIV-1特異的CTLクローンのサイトカイン産生プロフィール. 第33回日本免疫学会（福岡）平成15年12月8-10日
	7th Asia-Oceania Hitocompatibility Workshop and Conference (Karuizawa, Japan) September 16 - 19 , 2003.　 Best abstracts Best-1 Effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-1specific CD8+ T cells to suppress HIV-1 replication. (Oral Presentation)
	第4回熊本エイズセミナー、熊本、平成15年9月5日～6日 NefタンパクによるHLA ClassⅠ分子の発現低下とHIV-1特異的CD8T細胞のウイルス制御能への影響
2002	第５回白馬シンポジウム報告会（最新エイズ研究2002）抗原刺激によるHIV-1特異的CTLクローンの各種サイトカイン産生能の差異
	第32回日本免疫学会（東京） 2002年12月4日～6日 TCRからのシグナルを介したHIV-1特異的CTL cloneの各種サイトカインの産性能の差異


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