大学院生業績

2004-2010

小泉　寛和 （大学院博士課程2008年度修了）

■論文発表
2010	Jimmy D. Dikeakos, Katelyn M. Atkins, Laurel Thomas, Lori Emert-Sedlak, In-Ja L. Byeon, Jinwon Jung, Jinwoo Ahn, Matthew D. Wortmann, Ben Kukull, Masumichi Saito, Hirokazu Koizumi, Danielle M. Williamson, Masateru Hiyoshi, Eric Barklis, Masafumi Takiguchi, Shinya Suzu, Angela M. Gronenborn, Thomas E. Smithgall, and Gary Thomas, Small molecule inhibition of HIV-1-induced MHC-I downregulation identifies a temporally regulated switch in Nef action. Mol. Biol.Cell. 21:3279-3292, 2010
	Hirokazu Koizumi*, Masao Hashimoto*, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Different in vivo effects of HIV-1 immunodominant epitope-specific CTLs on selection of escape mutant viruses. J. Virol. 84: 5508-5519, 2010 (* equal contribution)
2009	Masao Hashimoto, Mitsutaka Kitano, Kazutaka Honda, Hirokazu Koizumi, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi, Selection of escape mutation by Pol154-162-specific cytotoxic T cells among chronically HIV-1-infected HLA-B*5401-positive individuals, Human Immunology, 72: 123-127, 2010
	Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung’u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi*, and Philip Goulder* (*equally contribution) Adaptation of HIV-1 to Human Leukocyte Antigen class I . Nature, 458: 641-645, 2009
	Atsuko Hachiya, Kazuki Shimane, Stefan G.Sarafianos, Eiichi N. Kodama, Yasuko Sakagami, Fujie Negishi, Hirokazu Koizumi, Hiroyuki Gatanaga, Masao Matsuoka, Masafumi Takiguchi and Shinichi Oka, Clinical relevance of substitutions in the connection subdomain and RNase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients, Antiviral Research In press
	Hirokazu Koizumi, Tomomi Iwatani, Junko Tanuma, Mamoru Fujiwara, Taisuke Izumi, Shinichi Oka, and Masafumi Takiguchi, Escape mutation selected by Gag28-36-specific cytotoxic T cells in HLA-A*2402-positive HIV-1-infected donors, Microbe and Infection, in press
2008	Mamoru Fujiwara, Junko Tanuma, Hirokazu Koizumi, Yuka Kawashima, Kazutaka Honda, Saori Mastuoka-Aizawa, Sachi Dohki, Shinichi Oka and Masafumi Takiguchi, Different Ability of Escape Mutant-Specific Cytotoxic T Cells to Suppress Replication of Escape Mutant and Wild-type HIV-1 in New Hosts, J. Virol., ,82: 138-147, 2008

■学会発表
2008	小泉寛和, 藤原守, 蜂谷敦子, 川島夕佳, 上野貴将, 滝口雅文, 高い抗ウイルス機能を持つHIV-1特異的CTLとHIV-1逃避変異体の出現の解析, 第56回ウイルス学会学術集会（岡山）平成20年10月26-28日
	Hirokazu Koizumi, Mamoru Fujiwara, Atsuko Hachiya, Yuka Kawashima, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi, Different effects of HIV-1-specific CTLs having a strong ability to suppress HIV-1 replication on selection of escape mutant viruses, 第9回熊本エイズセミナー (熊本) 平成20年9月18-19日
2007	小泉寛和、岩谷知美、蜂谷敦子、川島夕佳、上野貴将、岡慎一、滝口雅文(2007) HIV-1特異的CTLのHIV-1増殖抑制能とHIV-1逃避変異の出現の解析 第55回日本ウイルス学会学術集会(札幌) 10月21日-23日
2006	小泉寛和、藤原守、川島夕佳、上野貴将、岡慎一、滝口雅文 (2006) HLA-A*1101 拘束性 Nef特異的CTLのHIV-1増殖抑制機能とHIV-1感染者体内のウイルス量の関係　第５４回日本ウイルス学会学術集会（名古屋）11月19日〜21日
	H. Koizumi, M. Fujiwara, Y. Kawashima, T. Ueno, S. Oka, M. Takiguchi, Analysis of HLA-A*1101-restricted Nef73-specific CTLs with a strong ability to suppress HIV-1 replication, 7th AIDS Seminar in Kumamoto. (Kumamoto, Japan) September 21-22, 2006.
	H. Koizumi, M. Fujiwara, Y. kawashima, T. Ueno, S. Oka, M. Takiguchi (2006) Analysis of HLA-A*1101-restricted Nef73-specific CTLs with a strong abilitiy to suppress HIV-1 replication, Aids Vaccine 2006 Conference(Amsterdam,Netherlands)Aug 29-Sep 1, 2006
2005
	小泉寛和、藤原守、川島夕佳、有海康雄、上野貴将、岡慎一、滝口雅文 (2005)　2つのHLA-A*1101拘束性Nef特異的CTLによるHIV-1の排除と変異の誘導　第19回日本エイズ学会学術集会(熊本)12月1日〜3日
	小泉寛和、藤原守、川島夕佳、有海康雄、上野貴将、岡慎一、滝口雅文 (2005) 2つのHLA-A*1101拘束性Nef特異的CTLによるウイルス増殖抑制とウイルス変異の誘導　第53回日本ウイルス学会学術集会(横浜)11月20日〜22日
	Hirokazu Koizumi, Mamoru Fujiwara, Ueno Takamasa, Yasuo Ariumi, Shinichi Oka, Masafumi Takiguchi, Effect of two HLA-A*1101-restricted Nef-specific CTLs on HIV-1 evolution, AIDS VACCINE 2005 INTERNATIONAL CONFERENCE (Montreal, Quebec, Canada) September 6 to 9, 2005 →発表の様子はこちらから
	Hirokazu Koizumi, Mamoru Fujiwara, Takamasa Ueno, Shinichi Oka, Masafumi Takiguchi, Escape of HIV-1 from A*1101-restricted Nef-84-specific CTL, Seventh International Congress on AIDS in Asia and the Pacific (Kobe, Japan) July 1-5, 2005 →発表の様子はこちらから
2004	小泉寛和、冨山宏子、藤原守、上野貴将、岡慎一、滝口雅文 (2004) 長期未治療患者におけるNef 特異的HLA A＊1101 拘束性CD 8+T 細胞の解析 第18回日本エイズ学会学術集会(静岡) 2004年12月9日〜11日

院生業績TOPへ戻る