■ March 4, Thursday
■ March 5, Friday

■ March 4, Thursday ( 6th floor, GTC 9:00 - 17:10 )

Opening Remarks
Hiroaki Mitsuya
[Director for AIDS gCOE, Kumamoto Univ.]

Plenary Talk T and Joint SessionT 9:50-12:00 〔130〕
Chairs: Takamasa Ueno and Hirotomo Nakata
01 Paul L. Boyer
[ National Cancer Institute, USA ]
Slowing the Speeding Train: NRTIs versus HIV-1 Reverse Transcriptase

02 Takeo Kuwata
[ Kumamoto Univ. ]
Contribution of antibody response to effective viral suppression and progression of disease during SIV infection

03 Ryuta Sakuma
[ Tokyo Medical and Dental Univ. ]
Rhesus Monkey TRIM5alpha Mediated-Late Restriction of HIV-1 Lifecycle

04 Guillaume B.E. Stewart-Jones
[ University of Oxford, UK ]
Structural basis for T-cell receptor recongnition of HIV-1 epitopes in MHC class I


Parallel SessionU:
Immune ResponsesT
14:00-15:30 〔90〕
Chairs: Madoka Koyanagi and Kazutaka Honda
05 Masao Hashimoto
[ Kumamoto Univ. ]
Comprehensive analysis of escape mutation from HIV-1-specific cytotoxic T cells restricted by Asian allele HLA-B*5401

06 Tetsuo Tsukamoto
[ University of Tokyo ]
Benefit of single epitope-specific CD8+ T-cell memory induction without virus-specific CD4+ T-cell help for immunodeficiency virus control

07 Chihiro Motozono
[ Kumamoto Univ. ]
T cell receptor cross-reactivity toward variant HIV antigens is dependent on cognate peptide specificity

08 Jeffrey J. Ishizuka
[ Harvard Medical School, USA ]
Models of Protection and Pathogenesis in HIV-1 Immune Activation

Parallel SessionU:
PathogenesisT
16:00-17:10 〔70〕
Chairs: Shigeyoshi Harada and Terumasa Ikeda
09 Ranya Hassan
[ Kumamoto Univ. ]
A unique function of HIV-1 Nef that depends on its highest affinity host factor Hck

10 Masateru Hiyoshi
[ Kumamoto Univ. ]
Molecular mechanism by which HIV-1 Nef-Hck axis induces the Golgi dys-function

11 Kei Sato
[ Kyoto Univ. ]
A novel HIV-1 infection model using humanized mice


■ March 4, Thursday ( 2nd floor, CAIDS 14:00 - 17:10 )
Parallel SessionV:
Drug ResistanceT
14:00-15:30 〔90〕
Chairs: Kazuhisa Yoshimura and Yasushi Tojo
12 Shigeyoshi Harada
[ Kumamoto Univ. ]
In vitro selections of raltegravir resistant variants using diverse primary isolates, subtype B, C, CRF01_AE, and CRF08_BC

13 Masako Nishizawa
[ National Institute of Infectious Diseases ]
Analyses of minority drug-resistant populations in newly-diagnosed HIV/AIDS patients in Japan using highly sensitive allele-specific PCR

14 Kazuhiko Ide
[ Kumamoto Univ. ]
Novel HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) and a novel polycyclic ligand

15 Hiromi Aoki
[ Kumamoto Univ. ]
Early phase dynamics of HIV-1 infection in hPBM-transplanted NOD/SCID/Jak3-/- mice using infectious HIV-1 carrying fluorescent protein mCherry

Parallel SessionW:
Drug ResistanceU
16:00-17:10 〔70〕
Chairs: Nobuyo Kuwata and Hiromi Aoki
16 Takashi Masaoka
[ Nagoya Medical Center ]
Novel high-throughput phenotypic resistance assay for HIV-1 protease using wheat cell-free protein production system

17 Masayuki Amano
[ Kumamoto Univ. ]
Inserts in Gag Proteins Elicit Degradation of the Gag Proteins in Multi-drug-resistant HIV Variants

18 Manabu Aoki
[ Kumamoto Univ. ]
The binary mechanism of HIV-1 resistance to tipranavir(TPV): Loss of inhibition of protease catalytic activity and protease dimerization



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