9th AIDS Seminar in KUMAMOTO
　　　
　　 9th AIDS Seminar in KUMAMOTO Program
　　　
　　　 ■　18 September
　　　■　19 September
　　　■　Poster Session
■　19 September
Pathogenesis-I
8:00-9:45
Chairpersons: S. Harada[Kumamoto Univ.], S. Suzu[Kumamoto Univ.]
8:00-8:25 Tatsuo Shioda [Osaka Univ.]
Viral determinant of TRIM5α sensitivity

8:25-8:50 Akihide Ryo [NIID]
Identification of host factors required for HIV-1 Gag trafficking

8:50-9:05 Ranya Hassan [Kumamoto Univ.]
More severe protein maturation interference by HIV-1 Nef and Hck: molecular mechanism
and its restoration by small molecule compound

9:05-9:45 Gary Thomas [Vollum Institute]
HIV-1 Nef assembles a multi-kinase cascade to downregulate cell-surface MHC-I
Coffee break
9:45-10:00
Immunology-I
10:00-11:25
Chairpersons: M. Takiguchi[Kumamoto Univ.], T. Kuwata[Kumamoto Univ.]

10:00-10:25 Tetsuro Matano [Univ. of Tokyo]
Impact of vaccine-induced Gag-specific CTL responses on SIV control

10:25-10:45 Takamasa Ueno [Kumamoto Univ.]
The balance of power: Nef and CTL

10:45-11:25 Victor Appay [INSERM]
The nature of CD8+ T cell efficacy in HIV-1 infection
Immunology-II
11:25-12:20
Chairpersons: T. Takiguchi[Kumamoto Univ.], T. Ueno[Kumamoto Univ.]

11:25-11:40 Hiroshi Takata [Kumamoto Univ.]
Detailed analysis of functionally distinct human effector CD8+ T cell subsets

11:40-12:20 Rafick-Pierre Sekaly [Universite de Montreal]
Systems Biology approaches to The understanding of memory T cell homeostasis and pathogenesis
Lunch/Poster viewing
12:20-13:25
Drug/resistance
13:25-14:55
Chairpersons: H. Mitsuya [Kumamoto Univ.], S. Oka [IMCJ]

13:25-13:40 Kenji Maeda [NCI, NIH]
Structure-guided approach for the development of AIDS therapeutics: Design of CCR5 inhibitors and the study of their interactions with CCR5

13:40-14:00 Yasuhiro Koh [Kumamoto Univ.]
Non-peptidyl small molecule protease dimerization inhibitors (PDIs): molecular and structural analysis of their HIV-1 inhibition and interactions with protease monomer subunit

14:00-14:15 Atsuko Hachiya [Kumamoto Univ./IMCJ]
Mutations in the connection and RNase H subdomains of HIV-1 reverse transcriptase in the antiretroviral treatment-naive patients.

14:15-14:55 Michael A. Parniak [Univ. of Pittsburgh]
HIV ribonuclease H as a target for antiretroviral drug discovery
 
Coffee break
14:55-15:05
Pathogenesis-II
15:05-16:30
Chairpersons: S. Matsushita [Kumamoto Univ.], T. Matano T [Univ. of Tokyo]

15:05-15:45 Jason Brenchley [NIAID, NIH]
Mucosal dysfunction and immune activation in lentiviral infections

15:45-16:10 Tatsuhiko Igarashi [Kyoto Univ.]
“Work In Progress” toward developing a better non-human primate model for AIDS

16:10-16:30 Takeo Kuwata [Kumamoto Univ./NIAID, NIH]
Two modes of disease progression in SIV infection: Implication of naive CD4+ T cell depletion and autoantibodies for progressive CD4+ T cell decline

Closing Remarks Hiroaki Mitsuya [Kumamoto Univ.]
← 18 Sep.