Publications
2024
Takeo Kuwata,* Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Ryuta Uraki, Kyo Okazaki, Rumi Minami, Yoji Nagasaki, Mami Nagashima, Isao Yoshida, Kenji Sadamasu, Kazuhisa Yoshimura, Mutsumi Ito, Maki Kiso, Seiya Yamayoshi, Masaki Imai, Terumasa Ikeda, Kei Sato, Mako Toyoda, Takamasa Ueno, Takako Inoue, Yasuhito Tanaka, Kanako Tarakado Kimura, Takao Hashiguchi, Yukihiko Sugita, Takeshi Noda, Hiroshi Morioka, Yoshihiro Kawaoka, Shuzo Matsushita,* and G2P-Japan Consortium (*Corresponding)
Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case
Yudai Oishi #, Mako Toyoda # (#equal contribution), Nanami Hano, Chihiro Motozono, Takamasa Ueno, Makoto Takafuji * (*Correspondence)
Polycyclic aromatic polymer nanoparticles show potent infectious particle adsorption capability
Kenji Sugata, Mitsuyoshi Takatori, Omnia Reda, Benjy Jek Yang Tan, Masahito Tokunaga, Tomoo Sato, Mitsuharu Ueda, Yoshihisa Yamano, Atae Utsunomiya, Yorifumi Satou*
(*correspondence)
Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against adult T-cell leukemia/lymphoma
Eoghann White, Laura Papagno, Assia Samri, Kenji Sugata, Boris Hejblum, Amy R Henry, Daniel C Rogan, Samuel Darko, Patricia Recordon-Pinson, Yasmine Dudoit, Sian Llewellyn-Lacey, Lisa A Chakrabarti, Florence Buseyne, Stephen A Migueles, David A Price, Marie-Aline Andreola, Yorifumi Satou, Rodolphe Thiebaut, Christine Katlama, Brigitte Autran, Daniel C Douek, Victor Appay*
(*correspondence)
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1
Perpetual Nyame, Akihiro Togami, Tomofumi Yoshida, Takuya Masunaga, Mst Monira Begum, Hiromi Terasawa, Nami Monde, Yurika Tahara, Reiko Tanaka, Yuetsu Tanaka, Joyce Appiah-Kubi, Wright Andrews Ofotsu Amesimeku, Md Jakir Hossain, Masami Otsuka, Kazuhisa Yoshimura, Terumasa Ikeda, Tomohiro Sawa, Yorifumi Satou, Mikako Fujita, Yosuke Maeda, Hiroshi Tateishi, Kazuaki Monde*
(*correspondence)
A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24
Md Belal Hossain, Yoshikazu Uchiyama, Samiul Alam Rajib, Akhinur Rahman, Mitsuyoshi Takatori, Benjy Jek Yang Tan, Kenji Sugata, Mami Nagashima, Mamiyo Kawakami, Hitoshi Ito, Ryota Kumagai, Kenji Sadamasu, Yasuhiro Ogi, Tatsuya Kawaguchi, Tomokazu Tamura, Takasuke Fukuhara, Masahiro Ono, Kazuhisa Yoshimura, Yorifumi Satou*
(*correspondence)
A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI
Begum MM, Bokani A, Rajib SA, Soleimanpour M, Maeda Y, Yoshimura K, Satou Y, Ebrahimi D, Ikeda T* (*correspondence)
Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication
Tsujino S#, Deguchi S#, Nomai T#, Padilla-Blanco M#, Plianchaisuk A#, Wang L#, Begum MM#, Uriu K# (#equal contribution), Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima Hi, Sasaki-Tabata K, Guo Z, Hinay Jr. AA, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T*, Takayama K*, Zahradnik J*, Hashiguchi T*, Fukuhara T*, Sato K* (*equal correspondence)
Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant
Nozomi Kuse, Osamu Noyori, Naofumi Takahashi, Yu Zhang, Shinya Suzu, and Masafumi Takiguchi, Recognition of HIV-1-infected fibrocytes lacking Nef-mediated HLA-B downregulation by HIV-1-specific T cells. J Virol. 98: e00791-24, 2024
Masahiro Ono, Yorifumi Satou
Spectrum of Treg and Self-Reactive T cells: Single Cell Perspectives from Old Friend HTLV-1
Discovery Immunology
DOI : 10.1093/discim/kyae006.
Isaac Ngare ,Toong Seng Tan 1,Mako Toyoda 1,Takeo Kuwata 1,Soichiro Takahama ,Eriko Nakashima 3,Naoya Yamasaki ,Chihiro Motozono 1,Teruhisa Fujii ,Rumi Minami ,Godfrey Barabona ,Takamasa Ueno
Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV
Viruses
Begum MM, Ichihara K, Takahashi O, Nasser H, Jonathan M, Tokunaga K, Yoshida I, Nagashima M, Sadamasu K, Yoshimura K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K, Ikeda T* (*correspondence)
Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity.
Front Virol.
Islam MS, Rabin NN, Begum MM, Goto N, Tagawa R, Nagashima M, Sadamasu K, Yoshimura K, Sekine Y, Ikeda T*, Hayami S* (*equal correspondence).
Assessing the efficacy of GO-anchored filters versus various commercial masks.
RSC Appl Interfaces
Tamura T#, Mizuma K#, Nasser H#, Deguchi S#, Padilla-Blanco M#, Uriu K#, Tolentino JEM# (#equal contribution), Tsujino S, Suzuki R, Kojima I, Nao N, Shimizu R, Jonathan M, Kosugi Y, Guo Z, Hinay Jr. AA, Putri O, Kim Y, Tanaka YL, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Ito J, Irie T, Zahradnik J*, Ikeda T*, Takayama K*, Matsuno K*, Fukuhara T*, Sato K* (*equal correspondence).
Virological characteristics of the SARS-CoV-2 BA.2.86 variant.
Cell Host Microbe.
Click for more details →
2023
Omnia R, Monde K, Sugata K, Rahman A, Sakhor W, Rajib SA, Sithi SN, Tan BJY, Niimura K, Motozono C, Maeda K, Ono M, Takeuchi H, Satou Y.
HIV-Tocky system to visualize proviral expression dynamics.
Communications Biology, 7: 344, 2024. doi: 10.1038/s42003-024-06025-8.
Godfrey Barabona, Isaac Ngare, Doreen Kamori, Lilian Nkinda, Yusuke Kosugi, Ambele Mawazo, Rayi Ekwabi, Gloria Kinasa, Harrison Chuwa,The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato, Bruno Sunguya &Takamasa Ueno
Neutralizing immunity against coronaviruses in Tanzanian health care workers
DOI: 10.1038/s41598-024-55989-4
Godfrey Barabona, Isaac Ngare, Doreen Kamori, Lilian Nkinda, Yusuke Kosugi, Ambele Mawazo, Rayi Ekwabi, Gloria Kinasa, Harrison Chuwa,The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato, Bruno Sunguya &Takamasa Ueno
Neutralizing immunity against coronaviruses in Tanzanian health care workers
DOI: 10.1038/s41598-024-55989-4
Jonathan M, Ikeda T* (*correspondence)
APOBEC3 family proteins as drivers of virus evolution
Front Virol
Front Virol DOI : https://doi.org/10.1016/j.chom.2024.01.001
詳しくはこちら →
Nozomi Kuse, Hiroyuki Gatanaga, Yu Zhang, Takayuki Chikata, Shinichi Oka, and Masafumi Takiguchi, Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8+ T cells. J. Virol. 97: e0102423, 2023
Takayuki Chikata, Hiroyuki Gatanaga, Hung The Nguyen, Daisuke Mizushima, Yu Zhang, Nozomi Kuse, Shinichi Oka, and Masafumi Takiguchi, HIV-1 protective epitope-specific CD8+ T cells in HIV-1-exposed seronegative individuals. iScience 26: 108089, 2023
Emmanuel Nkuwi, George P. Judicate, Toong Seng Tan, Godfrey Barabona, Mako Toyoda, Bruno Sunguya, Doreen Kamori, Takamasa Ueno.Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity
Journal of Virology DOI: 10.1128/jvi.00823-23
Emmanuel Nkuwi, George P. Judicate, Toong Seng Tan, Godfrey Barabona, Mako Toyoda, Bruno Sunguya, Doreen Kamori, Takamasa Ueno.Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity
Journal of Virology DOI: 10.1128/jvi.00823-23
Ikeda T#,* (*correspondence), Shimizu R# (#equal contribution), Nasser H, Carpenter MA, Cheng AZ, Brown WL, Sauter D, Harris RS.
APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1.
mBio
Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Godfrey Barabona, Akiko Yonekawa, Nobuyuki Shimono, Rumi Minami, Yoji Nagasaki, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Shuzo Matsushita , Takeo Kuwata, Takamasa Ueno.Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay. https://doi.org/10.1128/spectrum.00660-2
Tamura T#, Ito J#, Uriu K#, Zahradnik J#, Kida I#, Anraku Y, Nasser H#, Shofa M#, Oda Y#, Lytras S# (#equal contribution), Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Lin P, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S*, Matsuno K*, Takayama K*, Sato K* (*equal correspondence).
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
Uchida T, Teraoka Y, Imamura M, Abe-Chayama H, Makokha GN, Hayes CN, Aikata H, Hamamura S, Ishida Y, Tateno C, Shirouzu T, Kawai S, Tanaka Y, Ohdan H, Okada S, Chayama K.
A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system.
Matsumoto K, Kuwata T, Tolbert WD, Richard J, Ding S, Prévost J, Takahama S, Judicate GP, Ueno T, Nakata H, Kobayakawa T, Tsuji K, Tamamura H, Smith AB 3rd, Pazgier M, Finzi A, Matsushita S. , Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates. ,Journal of Virology ,IF: 6.549
Islam MS, Fukuda M, Hossain MJ, Rabin NN, Tagawa R, Nagashima M, Sadamasu K, Yoshimura K, Sekine Y, Ikeda T*, Haymai S* (*equal correspondence). SARS-CoV-2 suppression depending on pH of graphene oxide nanosheet. Nanoscale Adv, 5, 2413-2417, 2023.
Phikulsod P, Kariya R, Panaampon J, Okada S.
Dihydroartemisinin Induced Apoptosis and Synergized With Chemotherapy in Pleural Effusion Lymphoma Cells.
Phumesin P, Panaampon J, Kariya R, Limjindaporn T, Yenchitsomanus PT, Okada S.
Cepharanthine inhibits dengue virus production and cytokine secretion.
2022
Kimura I#, Yamasoba D#, Nasser H#, Zahradnik J#, Kosugi Y#, Wu J# (#equal contribution), Nagata K, Uriu, K, Tanaka YL, Ito J, Shimizu R, Tan TS, Butlertanaka EP, Asakura H, Sadamasu K, Yoshimura K, Ueno T, Takaori-Kondo A, Schreiber G, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Toyoda M, Shirakawa K, Irie T, Saito A*, Nakagawa S*, Ikeda T*, Sato K* (*equal correspondence)
The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant.
Md Belal Hossain, Tomoko Kobayashi#, Sakurako Makimoto, Misaki Matsuo, Kohei Nishikaku, Benjy Jek Yang Tan, Akhinur Rahman, Samiul Alam Rajib, Kenji Sugata, Nagaki Ohnuki, Masumichi Saito, Toshiaki Inenaga, Kazuhiko Imakawa and Yorifumi Satou.Clone dynamics and its application for the diagnosis in Enzootic Bovine Leukosis
National Library of Medicine →
2021
Yu Zhang, Takayuki Chikata, Nozomi Kuse, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi, Immunological control of HIV-1 disease progression by rare protective HLA allele. J. Virol. 96 e01248-22, 2022
Toong Seng Tan, Mako Toyoda, Hirotaka Ode, Godfrey Barabona, Hiroshi Hamana, Mizuki Kitamatsu, Hiroyuki Kishi, Chihiro Motozono, Yasumasa Iwatani, Takamasa Ueno, Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike, Journal of Virology, Vol. 96, 2001162-22, 2022
Nozomi Kuse,* Yu Zhang,* Takayuki Chikata,* Hung The Nguyen, Shinichi Oka, Hiroyuki Gatanaga, and Masafumi Takiguchi (*equal contribution), Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine, Nat. Commun. 13: 5251, 2022
Hung The Nguyen*, Nozomi Kuse*, Yu Zhang, Hayato Murakoshi, Yosuke Maeda, Yoshiko Tamura, Rie Maruyama, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Shinichi Oka, Takayuki Chikata, and Masafumi Takiguchi (*equal contribution), Control of HIV-1 replication by CD8+ T cells specific for two novel Pol protective epitopes in HIV-1 subtype A/E infection, J. Virol, 96: e00811-22, 2022
本園千尋 講師、豊田真子 特任助教、Tan Toong Seng研究員らの新型コロナウイルスオミクロン株に対するT細胞応答に関する研究成果が、Nature Communications誌に公開されました！
プレスリリース：オミクロンBA.1株のG446S変異がワクチン誘導型T細胞の抗ウイルス機能を高めることを発見
Nasser H, Takahashi N, Eltalkhawy YM, Reda O, Lotfi S, Nasu K, Sakuragi J, Suzu S. Inhibitory and stimulatory effects of IL-32 on HIV-1 infection. J Immunol 209:970-978, 2022
URL: https://www.jimmunol.org/content/early/2022/08/05/jimmunol.2200087
Takayuki Chikata, Wayne Paes, Nozomi Kuse, Thomas Partridge, Hiroyuki Gatanaga, Yu Zhang, Kimiko Kuroki, Katsumi Maenaka, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Impact of micropolymorphism outside the peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection, J. Virol. 96: e00432-22, 2022
Daichi Yamasoba#, Izumi Kimura#, Hesham Nasser#, Yuhei Morioka#, Naganori Nao#, Jumpei Ito#, Keiya Uriu#, Masumi Tsuda#, Jiri Zahradnik#, Kotaro Shirakawa, Rigel Suzuki, Mai Kishimoto, Yusuke Kosugi, Kouji Kobiyama, Teppei Hara, Mako Toyoda, Yuri L. Tanaka, Erika P. Butlertanaka, Ryo Shimizu, Hayato Ito, Lei Wang, Yoshitaka Oda, Yasuko Orba, Michihito Sasaki, Kayoko Nagata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Jin Kuramochi, Motoaki Seki, Ryoji Fujiki, Atsushi Kaneda, Tadanaga Shimada, Taka-aki Nakada, Seiichiro Sakao, Takuji Suzuki, Takamasa Ueno, Akifumi Takaori-Kondo, Ken J. Ishii, Gideon Schreiber, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hirofumi Sawa, Akatsuki Saito*, Takashi Irie*, Shinya Tanaka*, Keita Matsuno*, Takasuke Fukuhara*, Terumasa Ikeda*, Kei Sato*. (#Equal contribution; *Corresponding author)
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. 2022
DOI: 10.1016/j.cell.2022.04.035
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00533-5
DOI：
10.1038/s41467-022-30029-9
URL：
https://www.nature.com/articles/s41467-022-30029-9
https://www.amed.go.jp/news/release_20220506.html
https://www.kumamoto-u.ac.jp/whatsnew/seimei-sentankenkyu/20220506
Yasuo Ariumi, Host cellular RNA helicases regulate SARS-CoV-2 infection, J. Virol. 2022.
Benjy Jek Yang Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono and Yorifumi Satou
DOI:10.1172/JCI150472
JCI
熊本大学
Imperial College London
Masateru Hiyoshi, Naofumi Takahashi, Youssef M. Eltalkhawy, Osamu Noyori, Sameh Lotfi, Jutatip Panaampon, Seiji Okada, Yuetsu Tanaka, Takaharu Ueno, Jun-ichi Fujisawa, Yuko Sato, Tadaki Suzuki, Hideki Hasegawa, Shinya Suzu, M-Sec induced by HTLV-1 mediates an efficient viral transmission, Plos Pathogens, 2021
DOI：org/ 10.1371/journal.ppat.1010126
著者：齊藤暁#, 入江崇#, 鈴木理滋#, 前村忠#, Hesham Nasser#, 瓜生慧也#, 小杉優介#, 白川康
太郎, 貞升健志, 木村出海, 伊東潤平, 呉佳齊, 岩附研子, 伊藤睦美, 山吉誠也, Samantha Loeber,
津田真寿美, Lei Wang, 大園誠也, バトラー田中英里佳, 田中友理, 清水凌, 清水健太, 吉松組子,
川端涼子, 坂口剛正, 徳永研三, 吉田勲, 浅倉弘幸, 長島真美, 数馬安浩, 野村亮介, 堀澤欣史, 吉村
和久, 高折晃史, 今井正樹, The Genotype to Phenotype Japan (G2P-Japan) Consortium, 田中
伸哉*, 中川草*, 池田輝政*, 福原崇介*, 河岡義裕*, 佐藤佳*
（#Equal contribution; *Corresponding author）
熊大プレスリリース
Nozomi Kuse,* Hayato Murakoshi,* Tomohiro Akahoshi,* Takayuki Chikata, Katherine L James, Hiroyuki Gatanaga, Sarah L Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi (*equal contribution), Collaboration of a detrimental HLA-B*35:01 allele with HLA-A*24:02 in co-evolution of HIV-1 with T-cells leading to poorer clinical outcomes, J. Virol. 95: e01259-21, 2021
Nozomi Kuse, Tomohiro Akahoshi, and Masafumi Takiguchi, STING ligand-mediated priming of functional CD8+ T-cells specific for HIV-1 protective epitopes from naive T-cells, J. Virol. 95: e00699-21, 2021
新型コロナに感染して回復した症例から中和抗体を分離し、ウイルスへの強い結合活性をもった中和抗体が変異株へも有効であることを発表しました。
Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19
Yu Kaku, Takeo Kuwata* Hasan Md Zahid, Takao Hashiguchi, Takeshi Noda, Noriko Kuramoto, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Kazuya Shimura, Chiho Onishi, Yukiko Muramoto, Tateki Suzuki, Jiei Sasaki, Yoji Nagasaki, Rumi Minami, Chihiro Motozono, Mako Toyoda, Hiroshi Takahashi, Hiroto Kishi, Kazuhiko Fujii, Tsuneyuki Tatsuke, Terumasa Ikeda, Yosuke Maeda, Takamasa Ueno, Yoshio Koyanagi, Hajime Iwagoe, and Shuzo Matsushita*
ウイルスの感染力を高め、日本人に高頻度な細胞性免疫応答から免れるSARS-CoV-2変異の発見した論文を発表しました。
Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*corresponding authors)
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.
Cell Host and Microbe (2021)
→ Web site (Cell Host and Microbe 2021 )
Joint research about bovine leukemia virus with Tokyo University of Agriculture and Tokai University has been published in Scientific Reports. (Division of Genomics and Transcriptomics)
[A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP]
2020
Yu Zhang, Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Giang Van Tran, Trung Vu Nguyen, Hiroyuki Gatanaga, Kinh Van Nguyen, Shinichi Oka, Nozomi Kuse, and Masafumi Takiguchi, Effect of difference in consensus sequence between HIV-1 subtype A/E and subtype B viruses on elicitation of Gag-specific CD8+ T cells and accumulation of HLA-associated escape mutations, J. Virol. 95: e02061-20, 2021
Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Chengcheng Zou, Mohamed Ali Borghan, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Nozomi Kuse, and Masafumi Takiguchi, Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15:05 on clinical outcome in HIV-1 subtype A/E infection, AIDS 35: 33-43, 2021 (Division of International Collaboration Research / Takiguchi Lab.)
Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J. Brumme, Hayato Murakoshi, Zabrina L. Brumme, Shinichi Oka, and Masafumi Takiguchi, T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics, PLoS Pathog. 16(12): e1009177, 2020
Joint research with Imperial College London was published in Frontiers in Immunology. [T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis]
→ Web site (Frontiers in Immunology)
Yu Zhang, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Hayato Murakoshi, and Masafumi Takiguchi, Role of escape mutant-specific T cells in suppression of HIV-1 replication and co-evolution with HIV-1, J. Virol. 94:e01151, 2020 (Division of International Collaboration Research / Takiguchi Lab.)
Yamamoto N*, Ariumi Y*(*co-first), Nishida Y, Yamamoto R, Bauer G, Gojobori T, Shimotohno K, Mizokami M. (2020) SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene Jul 3:144944. Online ahead of print(Division of Retroelement)
Yamamoto N*, Ariumi Y*(*co-first), Nishida Y, Yamamoto R, Bauer G, Gojobori T, Shimotohno K, Mizokami M. SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene Jul 3:144944, 2020 (Division of Retrolelement)
2019
Katsuya, H., Islam, S., Tan, B., Ito, J., Miyazato, P., Matsuo, M., Inada, Y., Iwase, S., Uchiyama, Y., Hata, H., Sato, T., Yagishita, N., Araya, N., Ueno, T., Nosaka, K., Tokunaga, M., Yamagishi, M., Watanabe, T., Uchimaru, K., Fujisawa, J., Utsunomiya, A., Yamano, Y. and Satou, Y. The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 29(3), pp.724-735.e4. , 2019 (Division of Genomics and Transcriptomics)
Iwase SC, Miyazato P, Katsuya H, Islam S, Tan B, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K, and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus. Sci Rep, 9(1):12326, 2019 (Division of Genomics and Transcriptomics)
Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S. Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma. Clinical & Translational Immunology 8 (8): e1074, 2019. (Division of Infection and Hematopoiesis)
G Barabona, M Mahiti, S Masoud, P Mbelele, A Shaban Mgunya, L Minja, B Sunguya, U Shigemi, M Matsuda, A Hachiya, Y Iwatani, E Lyamuya, T Ueno. Pre-treatment and acquired HIV drug resistance in Dar es Salaam, Tanzania in the era of tenofovir and routine viral load monitoring. J Antimicrob Chemother https://doi.org/10.1093/jac/dkz272 , 2019 (Division of Infection and Immunity)
Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Identification of immunodominant HIV-1 epitopes presented by HLA-C*12:02, a protective allele, using an immunopeptidomics approach, J. Virol, 93(17), e00634-19,2019 (Division of International Collaboration Research / Takiguchi Lab.)
Ueno M, Nogawa M, Siddiqui R, Watashi K, Wakita T, Kato N, Ikeda M, Okimura T, Isaka S, Oda T, Ariumi Y. Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection. Int. J. Biol. Macromol. 124:282-290, 2019.（Division of Retroelement）
Smita Kulkarni, Alexandra Lied, Viraj Kulkarni, Marijana Rucevic, Maureen P. Martin, Victoria Walker-Sperling, Stephen K. Anderson, Rodger Ewy, Sukhvinder Singh, Hoang Nguyen, Paul J. McLaren, Mathias Viard, Vivek Naranbhai, Chengcheng Zou, Zhansong Lin, Hiroyuki Gatanaga, Shinichi Oka, Masafumi Takiguchi, Chloe L. Thio, Joseph Margolick, Gregory D. Kirk, James J. Goedert, W. Keith Hoots, Steven G. Deeks, David W. Haas, Nelson Michael, Bruce Walker, Sylvie Le Gall, Fatema Z. Chowdhury, Xu G. Yu and Mary Carrington, CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome, Nat Immunol. 20:824-834, 2019（Division of International Collaboration Research / Takiguchi Lab）
Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Anna Lissina, Takuya Yamamoto, Victor Appay, and Masafumi Takiguchi, Priming of HIV-1-specific CD8+ T cells with strong functional properties from naive T cells, EBioMedicine 42:109-119, 2019（Division of International Collaboration Research / Takiguchi Lab）
Chengcheng Zou*, Hayato Murakoshi*, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomas Hanke, and Masafumi Takiguchi (*Equal contribution), Effective suppression of HIV-1 replication by CTLs specific for Pol epitopes in conserved mosaic vaccine immunogens, J. Virol. 93:e02142-18, 2019（Division of International Collaboration Research / Takiguchi Lab）
Copyright @ 2019 Joint Research Center for Human Retrovirus Infection, Kumamoto University