ACHIEVEMENTS

研究実績

過去の発表論⽂

2019年

  • Miyazato P, Matsuo M, Tan BJY, Tokunaga M, Katsuya H, Islam S, Ito J, Murakawa Y, Satou Y. HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP. Retrovirology, 16(1):38, doi: 10.1186/s12977-019-0500-3,2019.
  • Katsuya H, Islam S, Tan BJY, Ito J, Miyazato P, Matsuo M, Inada Y, Iwase SC, Uchiyama Y, Hata H, Sato T, Yagishita N, Araya N, Ueno T, Nosaka K, Tokunaga M, Yamagishi M, Watanabe T, Uchimaru K, Fujisawa JI, Utsunomiya A, Yamano Y, Satou Y. The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 29(3):724-735.e4, doi: 10.1016/j.celrep.2019.09.016, 2019.
  • Iwase S, Miyazato P, Katsuya H, Islam S, Tan BJY, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus.
    Scientific Reports, 29(3):724-735.e4, doi: 10.1016/j.celrep.2019.09.016, 2019.
  • Baba M, Furuya M, Motoshima T, Martin L, Funasaki S, Wenjuan M, Hong-Wei S, Hasumi H, Ying H, Kato I,
    Kadomatsu T, Satou Y, Nicole MN, Baktiar OK, Lilia I, Joseph DK, Luh AWK, Hasumi Y, Sugiyama A,
    Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T,
    Oike Y, Laura SS and W. Marston L. TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.
    Molecular Cancer Research, 17(8):1613-1626, doi: 10.1158/1541-7786.MCR-18-1235, 2019.
  • 松尾美沙希宮里パオラ佐藤賢文
    「HTLV-1感染細胞クローン選択におけるウイルス組み込み部位の意義
    〜レトロウイルスHTLV-1とヒトゲノムの相互作用に関する最近の話題〜」
    ウイルス 第69巻 第1号 2019年
  • 佐藤賢文「HIV-1ウイルスリザーバの成立・維持の仕組み」 日本エイズ学会誌 21:167-172 2019年

2018年

  • Miura M, Miyazato P, Satou Y, Tanaka Y, Bangham CRM. Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5′ and 3′ long terminal repeats.
    Wellcome Open Research, 3:105, doi: 10.12688/wellcomeopenres.14741.2. eCollection 2018, 2018.
  • Katsuya H, Cook LBM, Rowan AG, Satou Y, Taylor GP, Bangham CRM. Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma.
    Biomarker Research, 6:24, doi: 10.1186/s40364-018-0138-7, 2018.
  • Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T,
    Satou Y, Matsushita S. Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: retrospective longitudinal analysis.
    Journal of Acquired Immune Deficiency Syndromes, 78(2):239-247, doi: 10.1097/QAI.0000000000001662, 2018.

2017年

  • Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y,
    Miyazato P,
    Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K. Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.
    Scientific Reports, 7(1):6913, doi: 10.1038/s41598-017-07307-4, 2017.

2016年

  • Miyazato P, Katsuya H,
    Fukuda A, Uchiyama Y, Matsuo M, Tokunaga M, Hino S , Nakao M, Satou Y. Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome. Scientific Reports, 6:28324, doi: 10.1038/srep28324, 2016.
  • Miyazato P, Matsuo M, Katsuya H, Satou Y. Transcriptional and Epigenetic Regulatory Mechanisms affecting HTLV-1 provirus. Viruses, 8(6):171, doi: 10.3390/v8060171, 2016.
  • Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M,
    Fukuda A, Nosaka K, Watanabe T, Rowan A, Nakao M, Bangham C. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proceedings of the National Academy of Sciences of the United States of America, 113(11):3054-9, doi: 10.1073/pnas.1423199113, 2016.
    [熊大HP][EurekAlert!HP][HTLV-1学会]

2014年

  • Zhao T, Satou Y, Matsuoka M. Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice. Archives of Virology. 159(7):1849-56, doi: 10.1007/s00705-014-2099-y, 2014.

2013年

  • Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y, Ito M, Aihara K, Dong Sung An and Koyanagi Y. HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo. PLoS Pathogens, 9(12):e1003812, doi: 10.1371/journal.ppat.1003812, 2013.
  • Nanae Yamamoto-Taguchi, Yorifumi Satou, Paola Miyazato, Koichi Ohshima, Masanori Nakagawa, Koko Katagiri, Tatsuo Kinashi, Masao Matsuoka.HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. PLoS Pathog., 9(9):e1003630, doi: 10.1371/journal.ppat.1003630, 2013.
  • Satou Y, Matsuoka M. Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1.Reviews in Medical Virology, 10:885, doi: 10.3389/fmicb.2019.00885, 2013.

2012年

  • Satou Y, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, Matsuoka M. HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. Retrovirology, 9:46, doi: 10.1186/1742-4690-9-46, 2012.
  • Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, and Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines, Blood, 119(2):434-44, doi: 10.1182/blood-2011-05-357459, 2012.
  • Satou Y, Matsuoka M. Molecular and cellular mechanism of leukemogenesis of ATL; emergent evidence of significant role of HBZ in HTLV-1-induced pathogenesis. Leukemia Research and Treatment, 2012:213653, doi: 10.1155/2012/213653, 2012.

2011年

  • Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T, and Matsuoka M. HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood, 118: 118(7):1865-76, doi: 10.1182/blood-2010-12-326199, 2011.
  • Shimizu-Kohno K, Satou Y, Arakawa F, Kiyasu J, Kimura Y, Niino D, Sugita Y, Ishikawa F, Matsuoka M, Ohshima K. Detection of human T-cell leukemia virus type 1 by means of HBZ in situ hybridization in formalin-fixed and paraffin-embedded tissues. Cancer Science, 102(7):1432-6, doi: 10.1111/j.1349-7006.2011.01946.x, 2011.
  • Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, and Koyanagi Y. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood, 117(21):5663-73, doi: 10.1182/blood-2010-09-305979, 2011.
  • Hagiya K, Yasunaga J, Satou Y, Oshima K and Matsuoka M. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. Retrovirology, 8:19, doi: 10.1186/1742-4690-8-19, 2011.
  • Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, Shimizu K, Ohshima K, Green P, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M, HTLV-1 bZIP Factor Induces T-cell Lymphoma and Systemic Inflammation In Vivo.PLoS Pathogens, 7(2):e1001274, doi: 10.1371/journal.ppat.1001274, 2011.

2010年以前

  • Satou Y and Matsuoka M. HTLV-1 and the host immune system: How the virus disrupts immune regulation, leading to HTLV-1 associated diseases. Journal of Clinical and Experimental Hematopathology, 50(1):1-8, doi: 10.3960/jslrt.50.1, 2010.
  • Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M. APOBEC3G Generates Nonsense Mutations in HTLV-1 Proviral Genomes In Vivo. Journal of Virology, 84(14):7278-87, doi: 10.1128/JVI.02239-09, 2010.
  • Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y. In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology, 6:19, doi: 10.1186/1742-4690-6-19, 2009.
  • Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, Fujii M, Matsuoka M. Human T-cell Leukemia virus type 1 bZIP factor selectively suppresses classical pathway of NF-kB. Blood, 113(12):2755-64, doi: 10.1182/blood-2008-06-161729, 2009.
  • Yoshida M, Satou Y, Yasunaga JI, Fujisawa JI, Matsuoka M. Transcriptional control of spliced and unspliced HTLV-1 bZIP factor gene. Journal of Virology, 86(2):107-12, doi: 10.1532/IJH97.07103, 2008.
  • Satou Y, Matsuoka M. Implication of the HTLV-I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia. International Journal of hematology, 107-12, doi: 10.1532/IJH97.07103, 2007.
  • Satou Y, Yasunaga JI, Yoshida M, Matsuoka M. HTLV- I bZIP factor gene mRNA supports proliferation of adult T-cell leukemia cells. Proceedings of the National Academy of Sciences of the United States of America, 113(12):2755-64, doi: 10.1182/blood-2008-06-161729, 2006.
  • Doi K, Wu X, Taniguchi Y, Yasunaga JI, Satou Y, Okayama A, Nosaka K, Matsuoka M. Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states. Blood, 106(3):1048-5, doi: 10.1182/blood-2004-11-4350, 2005.
  • Yasunaga JI, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T, Mitsuya H, Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Research, 64(17):6002-9, doi: 10.1158/0008-5472.CAN-04-1422, 2004.
  • Satou Y, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia, 18(8):1357-63, doi: 10.1038/sj.leu.2403400, 2004.