Md Belal Hossain, Tomoko Kobayashi, Sakurako Makimoto, Misaki Matsuo, Kohei Nishikaku, Benjy Jek Yang Tan, Akhinur Rahman, Samiul Alam Rajib, Kenji Sugata, Nagaki Ohnuki, Masumichi Saito, Toshiaki Inenaga, Kazuhiko Imakawa, Yorifumi Satou. Clone Dynamics and Its Application for the Diagnosis of Enzootic Bovine Leukosis. Journal of Virology. doi:https://doi.org/10.1128/jvi.01542-22
Benjy J. Y. Tan, Kenji Sugata, Masahiro Ono and Yorifumi Satou. HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system. Frontiers in Immunology. 13:991928. doi: 10.3389/fimmu.2022.991928
Tan B, Ono M, Satou Y. Single-cell transcriptome analysis of Treg, In: Ono M. (eds) Regulatory T Cells. pp259-278.
Victoria Maksimova, Susan Smith, Jaideep Seth, Cameron Phelps, Stefan Niewiesk, Yorifumi Satou, Patrick L Green, Amanda R Panfil. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Frontiers in Immunology. 13:954077. doi: 10.3389/fimmu.2022.954077
Matsuo M, Ueno T, Monde K, Sugata K, Tan B, Rahman A, Miyazato P, Uchiyama K, Islam S, Katsuya H, Nakajima S, Tokunaga M, Nosaka K, Hata H, Utsunomiya A, Fujisawa, Satou Y. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Nature Communications. 13,2405, 2022. doi:10.1038/s41467-022-30029-9
Monde K, Satou Y, Goto M, Uchiyama Y, Ito J, Kaitsuka T, Terasawa H, Monde N, Yamaga S, Matsusako T, Wei FY, Inoue I, Tomizawa K, Ono A, Era T, Sawa T, Maeda Y. Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells., J Virol. in press
Rajib SA, Ogi Y, Hossain MB, Tanaka E, Kawaguchi T, Satou Y. A SARS-CoV-2 Delta variant containing mutation in the probe binding region used for qRT-PCR test in Japan exhibited atypical PCR amplification and might induce false negative result Journal of Infection and Chemotherapy in press
Katsuya H, Cook L, Rowan AG, Melamed A, Turpin J, Ito J, Islam S, Miyazato P, Tan B, Matsuo M, Miyakawa T, Nakata H, Matsushita S, Taylor GP, Bangham CRM, Kimura S, Satou Y. Clonality of HIV-1 and HTLV-1 infected cells in naturally coinfected individuals. The Journal of Infectious Diseases 225(2), 317-326, 2022.
2021年
Tan B, Sugata K, Reda O, Matsuo M, Uchiyama K, Miyazato P, Hahaut V, Yamagishi M, Uchimaru K, Suzuki Y, Ueno T, Suzushima H, Katsuya H, Tokunaga M, Uchiyama Y, Nakamura H, Sueoka E, Utsunomiya A, Ono M, Satou Y. HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma. The Journal of Clinical Investigation 131(24), e150472, 2021.
Matsuda K, Islam S, Takada T, Tsuchiya K, Tan B, Hattori S, Katsuya H, Kitagawa K, Kim K,Matsuo M, Sugata K, Delino N, Gatanaga H, Yoshimura K, Matsushita S, Mitsuya H, Iwami S, Satou Y, Maeda K. A widely distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro. Cell Reports Methods 1(8), 100122, 2021.
Hiyoshi M, Takahashi N, Eltalkhawy YM, Noyori O, Lotfi S, Panaampon J, Okada S, Tanaka Y, Ueno T, Fujisawa JI, Sato Y, Suzuki T, Hasegawa H, Tokunaga M, Satou Y, Yasunaga JI, Matsuoka M, Utsunomiya A, Suzu S. M-Sec induced by HTLV-1 mediates an efficient viral transmission. PLoS Pathogens 17:e1010126, 2021.
Ohnuki N, Kobayashi T, Matsuo M, Nishikaku K, Kusama K, Torii Y, Inagaki Y, Hori M, Imakawa K, Satou Y. A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP. Scientific Reports 11(1), 4521, 2021.
Sugata K,Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman M, Anczurowski M, Wang C, Murata K, Saijo H, Kagoya Y, Ly D, Burt B, Butler M, Mak T, Hirano N. Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Nature Biotechnology doi: 10.1038/s41587-021-00836-4, 2021.
Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Mukouyama Y, Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, and Kubota Y. Blood and lymphatic systems are segregated by the FLCN tumor suppressor. Nature Communications, 11:6314, 11(1):6314, doi: 10.1038/s41467-020-20156-6, 2020.
Kalfaoglu B, Almeida-Santos J, Tye A C, Satou Y, Ono M. T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis. Frontiers in Immunology, 11:589380, doi: 10.3389/fimmu.2020.589380. eCollection 2020, 2020.
*国立研究開発法人日本医療研究開発機構(AMED) プレスリリース
*国立大学法人熊本大学 プレスリリース
Aso H, Nagaoka S, Kawakami E, Ito J, Misawa N, Islam S, Tan B, Nakaoka S, Ashizaki K, Shiroguchi K, Suzuki Y, Satou Y, Koyanagi Y, Sato K. Multi-omics investigation revealing comprehensive characteristics of HIV-1-infected cells in vivo. Cell Reports, 32(2):107887, doi: 10.1016/j.celrep.2020.107887, 2020.
2019年
Miyazato P, Matsuo M, Tan BJY, Tokunaga M, Katsuya H, Islam S, Ito J, Murakawa Y, Satou Y. HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP. Retrovirology, 16(1):38, doi: 10.1186/s12977-019-0500-3,2019.
Katsuya H, Islam S, Tan BJY, Ito J, Miyazato P, Matsuo M, Inada Y, Iwase SC, Uchiyama Y, Hata H, Sato T, Yagishita N, Araya N, Ueno T, Nosaka K, Tokunaga M, Yamagishi M, Watanabe T, Uchimaru K, Fujisawa JI, Utsunomiya A, Yamano Y, Satou Y. The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 29(3):724-735.e4, doi: 10.1016/j.celrep.2019.09.016, 2019.
Iwase S, Miyazato P, Katsuya H, Islam S, Tan BJY, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus. Scientific Reports, 29(3):724-735.e4, doi: 10.1016/j.celrep.2019.09.016, 2019.
Baba M, Furuya M, Motoshima T, Martin L, Funasaki S, Wenjuan M, Hong-Wei S, Hasumi H, Ying H, Kato I,
Kadomatsu T, Satou Y, Nicole MN, Baktiar OK, Lilia I, Joseph DK, Luh AWK, Hasumi Y, Sugiyama A,
Kurahashi R, Nishimoto K, Oyama M, Nagashima Y, Kuroda N, Araki K, Eto M, Yao M, Kamba T, Suda T,
Oike Y, Laura SS and W. Marston L. TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease. Molecular Cancer Research, 17(8):1613-1626, doi: 10.1158/1541-7786.MCR-18-1235, 2019.
Miura M, Miyazato P, Satou Y, Tanaka Y, Bangham CRM. Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5′ and 3′ long terminal repeats. Wellcome Open Research, 3:105, doi: 10.12688/wellcomeopenres.14741.2. eCollection 2018, 2018.
Katsuya H, Cook LBM, Rowan AG, Satou Y, Taylor GP, Bangham CRM. Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma. Biomarker Research, 6:24, doi: 10.1186/s40364-018-0138-7, 2018.
Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S. Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: retrospective longitudinal analysis. Journal of Acquired Immune Deficiency Syndromes, 78(2):239-247, doi: 10.1097/QAI.0000000000001662, 2018.
2017年
Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y,
Miyazato P,
Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K. Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model. Scientific Reports, 7(1):6913, doi: 10.1038/s41598-017-07307-4, 2017.
2016年
Miyazato P, Katsuya H,
Fukuda A, Uchiyama Y, Matsuo M, Tokunaga M, Hino S , Nakao M, Satou Y. Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome. Scientific Reports, 6:28324, doi: 10.1038/srep28324, 2016.
Miyazato P, Matsuo M, Katsuya H, Satou Y. Transcriptional and Epigenetic Regulatory Mechanisms affecting HTLV-1 provirus. Viruses, 8(6):171, doi: 10.3390/v8060171, 2016.
Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M,
Fukuda A, Nosaka K, Watanabe T, Rowan A, Nakao M, Bangham C. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proceedings of the National Academy of Sciences of the United States of America, 113(11):3054-9, doi: 10.1073/pnas.1423199113, 2016. [熊大HP][EurekAlert!HP][HTLV-1学会]
2014年
Zhao T, Satou Y, Matsuoka M. Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice. Archives of Virology. 159(7):1849-56, doi: 10.1007/s00705-014-2099-y, 2014.
2013年
Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y, Ito M, Aihara K, Dong Sung An and Koyanagi Y. HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo. PLoS Pathogens, 9(12):e1003812, doi: 10.1371/journal.ppat.1003812, 2013.
Satou Y, Matsuoka M. Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1.Reviews in Medical Virology, 10:885, doi: 10.3389/fmicb.2019.00885, 2013.
2012年
Satou Y, Utsunomiya A, Tanabe J, Nakagawa M, Nosaka K, Matsuoka M. HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. Retrovirology, 9:46, doi: 10.1186/1742-4690-9-46, 2012.
Sugata K, Satou Y, Yasunaga J, Hara H, Ohshima K, Utsunomiya A, Mitsuyama M, and Matsuoka M. HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines, Blood, 119(2):434-44, doi: 10.1182/blood-2011-05-357459, 2012.
Satou Y, Matsuoka M. Molecular and cellular mechanism of leukemogenesis of ATL; emergent evidence of significant role of HBZ in HTLV-1-induced pathogenesis. Leukemia Research and Treatment, 2012:213653, doi: 10.1155/2012/213653, 2012.
2011年
Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T, and Matsuoka M. HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood, 118: 118(7):1865-76, doi: 10.1182/blood-2010-12-326199, 2011.
Shimizu-Kohno K, Satou Y, Arakawa F, Kiyasu J, Kimura Y, Niino D, Sugita Y, Ishikawa F, Matsuoka M, Ohshima K. Detection of human T-cell leukemia virus type 1 by means of HBZ in situ hybridization in formalin-fixed and paraffin-embedded tissues. Cancer Science, 102(7):1432-6, doi: 10.1111/j.1349-7006.2011.01946.x, 2011.
Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, and Koyanagi Y. A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood, 117(21):5663-73, doi: 10.1182/blood-2010-09-305979, 2011.
Hagiya K, Yasunaga J, Satou Y, Oshima K and Matsuoka M. ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells. Retrovirology, 8:19, doi: 10.1186/1742-4690-8-19, 2011.
Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, Shimizu K, Ohshima K, Green P, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M, HTLV-1 bZIP Factor Induces T-cell Lymphoma and Systemic Inflammation In Vivo.PLoS Pathogens, 7(2):e1001274, doi: 10.1371/journal.ppat.1001274, 2011.
2010年以前
Satou Y and Matsuoka M. HTLV-1 and the host immune system: How the virus disrupts immune regulation, leading to HTLV-1 associated diseases. Journal of Clinical and Experimental Hematopathology, 50(1):1-8, doi: 10.3960/jslrt.50.1, 2010.
Fan J, Ma G, Nosaka K, Tanabe J, Satou Y, Koito A, Wain-Hobson S, Vartanian JP, Matsuoka M. APOBEC3G Generates Nonsense Mutations in HTLV-1 Proviral Genomes In Vivo. Journal of Virology, 84(14):7278-87, doi: 10.1128/JVI.02239-09, 2010.
Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y. In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology, 6:19, doi: 10.1186/1742-4690-6-19, 2009.
Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, Fujii M, Matsuoka M. Human T-cell Leukemia virus type 1 bZIP factor selectively suppresses classical pathway of NF-kB. Blood, 113(12):2755-64, doi: 10.1182/blood-2008-06-161729, 2009.
Yoshida M, Satou Y, Yasunaga JI, Fujisawa JI, Matsuoka M. Transcriptional control of spliced and unspliced HTLV-1 bZIP factor gene. Journal of Virology, 86(2):107-12, doi: 10.1532/IJH97.07103, 2008.
Satou Y, Matsuoka M. Implication of the HTLV-I bZIP Factor Gene in the Leukemogenesis of Adult T-Cell Leukemia. International Journal of hematology, 107-12, doi: 10.1532/IJH97.07103, 2007.
Satou Y, Yasunaga JI, Yoshida M, Matsuoka M. HTLV- I bZIP factor gene mRNA supports proliferation of adult T-cell leukemia cells. Proceedings of the National Academy of Sciences of the United States of America, 113(12):2755-64, doi: 10.1182/blood-2008-06-161729, 2006.
Doi K, Wu X, Taniguchi Y, Yasunaga JI, Satou Y, Okayama A, Nosaka K, Matsuoka M. Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states. Blood, 106(3):1048-5, doi: 10.1182/blood-2004-11-4350, 2005.
Yasunaga JI, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T, Mitsuya H, Matsuoka M. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Research, 64(17):6002-9, doi: 10.1158/0008-5472.CAN-04-1422, 2004.
Satou Y, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro.Leukemia, 18(8):1357-63, doi: 10.1038/sj.leu.2403400, 2004.