ACHIEVEMENTS

研究実績

発表論⽂

2024年

  • Sugata K, Takatori M, Reda O, Tan BJY, Tokunaga M, Sato T, Ueda M, Yamano Y, Utsunomiya A, Satou Y. Viral antigen mismatch affects antiviral T-cell response and may impair immunotherapeutic efficacy against adult T-cell leukemia/lymphoma. The Journal of Infectious Diseases. 2024, jiae457. doi:10.1093/infdis/jiae457
  • White E, Papagno L, Samri A, Sugata K, Hejblum B, Henry AR, Rogan DC, Darko S, Recordon-Pinson P, Dudoit Y, Llewellyn-Lacey S, Chakrabarti LA, Buseyne F, Migueles SA, Price DA, Andreola MA, Satou Y, Thiebaut R, Katlama C, Autran B, Douek DC, Appay V. Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1. Nature Immunology. 25(9):1555-1564. doi: 10.1038/s41590-024-01931-9.
  • Nyame P, Togami A, Yoshida T, Masunaga T, Begum MM, Terasawa H, Monde N, Tahara Y, Tanaka R, Tanaka Y, Appiah-Kubi J, Amesimeku WO, Hossain MJ, Otsuka M, Yoshimura K, Ikeda T, Sawa T, Satou Y, Fujita M, Maeda Y, Tateishi H, Monde K. A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24. J Biol Chem. Online ahead of print. 107701. doi: 10.1016/j.jbc.2024.107701.
  • Hossain B, Uchiyama Y, Rajib SA, Rahman A, Takatori M, Tan BJY, Sugata K, Nagashima M, Kawakami M, Ito H, Kumagai R, Sadamasu K, Ogi Y, Kawaguchi T, Tamura T, Fukuhara T, Ono M, Yoshimura K, Satou Y. A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI. Communications medicine. 2024, 4(161), doi: 10.1038/s43856-024-00582-z
  • Begum MM, Bokani A, Rajib SA, Soleimanpour M, Maeda Y, Yoshimura K, Satou Y, Ebrahimi D, Ikeda T. Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication. Viruses. 16(7):1141. doi: 10.3390/v16071141.
  • Omnia R, Monde K, Sugata K, Rahman A, Sakhor W, Rajib SA, Sithi SN, Tan BJY, Niimura K, Motozono C, Maeda K, Ono M, Takeuchi H, Satou Y. HIV-Tocky system to visualize proviral expression dynamics. Communications Biology, 7: 344, 2024. doi: 10.1038/s42003-024-06025-8.
  • Ono M and Satou Y. Spectrum of Treg and Self-Reactive T cells: Single Cell Perspectives from Old Friend HTLV-1. Discovery Immunology 3(1):kyae006, 2024  doi: 10.1093/discim/kyae006.
  • Miyamura Y, Kamei S, Matsuo M, Usuki S, Uemura A, Satou Y, Ohguchi H, and Minami T.FOXO1 stimulates tip cell-enriched gene expression in endothelial cells. iScience, 2024, 27(3), 109161. doi: 10.1016/j.isci.2024.109161.
  • Konno Y, Uriu K, Chikata T, Takada T, Kurita JI, Ueda MT, Islam S, Yang Tan BJ, Ito J, Aso H, Kumata R, Williamson C, Iwami S, Takiguchi M, Nishimura Y, Morita E, Satou Y, Nakagawa S, Koyanagi Y, Sato K.Two-step evolution of HIV-1 budding system leading to pandemic in the human population. Cell Rep. 2024, 43(2),113697,doi: 10.1016/j.celrep.2024.113697

2023年

  • Tomita Y, Sakata S, Imamura K, Iyama S, Jodai T, Saruwatari K, Hamada S, Akaike K, Anai M, Fukusima K, Takaki A, Tsukamoto H, Goto Y, Motozono C, Sugata K, Satou Y, Ueno T, Ikeda T, Sakagami T. Association of Clostridium butyricum therapy using the live bacterial product CBM588 with the survival of patients with lung cancer receiving chemoimmunotherapy combination. Cancer. 2023, 16(1), 47, doi: 10.3390/cancers16010047.
  • Nakahata S, Enriquez-Vera D, M. Jahan I, Sugata K, Satou Y. Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review.Biomolecules, 2023, 13(10), 1543, doi: 10.3390/biom13101543.
  • Matsuda K, Tan BJY, Tsuchiya K, Rajib SA, Satou Y and Maeda K.Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model. STAR Protocol. 2023, 4(4), 102547,doi: 10.1016/j.xpro.2023.102547.
  • Katsuya H, Nakamura H, Maeda A, Ishii K, Nagaie T, Sano H, Sano H, Itamura H, Okamoto S, Ando T, Watanabe T, Uchimaru K, Satou Y, Sueoka E, Kimura S. HTLV-1 cell-free DNA in plasma as a potential biomarker in HTLV-1 carriers and adult T-cell leukemia-lymphoma. eJHaem. 2023, 4(3), 733-737, doi: 10.1002/jha2.725.
  • Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T, Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K, Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O, Satou Y, Saya H, Tan P, Baba H, Ishimoto T. Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. CANCER RESEARCH. 83 (5), 753–770, 10.1158/0008-5472.CAN-22-1890
  • Hossain B, Kobayashi T, Makimoto S, Matsuo M, Nishikaku K, Tan B, Rahman A, Rajib SA, Sugata K, Ohnuki N, Saito M, Inenaga T, Imakawa K, Satou Y. Clone Dynamics and Its Application for the Diagnosis of Enzootic Bovine Leukosis. Journal of Virology. doi:https://doi.org/10.1128/jvi.01542-22

2022年

  • Tan B, Sugata K, Ono M and Satou Y. HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system. Frontiers in Immunology. 13:991928. doi: 10.3389/fimmu.2022.991928
  • Tan B, Ono M, Satou Y. Single-cell transcriptome analysis of Treg, In: Ono M. (eds) Regulatory T Cells. pp259-278.
  • Maksimova V, Smith S, Seth J, Phelps C, Niewiesk S, Satou Y, Green P, Panfil A. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Frontiers in Immunology. 13:954077. doi: 10.3389/fimmu.2022.954077
  • Matsuo M, Ueno T, Monde K, Sugata K, Tan B, Rahman A, Miyazato P, Uchiyama K, Islam S, Katsuya H, Nakajima S, Tokunaga M, Nosaka K, Hata H, Utsunomiya A, Fujisawa,  Satou Y. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Nature Communications. 13,2405, 2022. doi:10.1038/s41467-022-30029-9
  • Monde K, Satou Y, Goto M, Uchiyama Y, Ito J, Kaitsuka T, Terasawa H, Monde N, Yamaga S, Matsusako T, Wei FY, Inoue I, Tomizawa K, Ono A, Era T, Sawa T, Maeda Y. Movements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells., J Virol. in press
  • Rajib SA, Ogi Y, Hossain MB, Tanaka E, Kawaguchi T, Satou Y. A SARS-CoV-2 Delta variant containing mutation in the probe binding region used for qRT-PCR test in Japan exhibited atypical PCR amplification and might induce false negative result. Journal of Infection and Chemotherapy 28(5):669-677, 2022.
  • Katsuya H, Cook L, Rowan AG, Melamed A, Turpin J, Ito J, Islam S, Miyazato P, Tan B, Matsuo M, Miyakawa T, Nakata H, Matsushita S, Taylor GP, Bangham CRM, Kimura S, Satou Y. Clonality of HIV-1 and HTLV-1 infected cells in naturally coinfected individuals. The Journal of Infectious Diseases 225(2), 317-326, 2022.

2021年

  • Tan B, Sugata K, Reda O, Matsuo M, Uchiyama K, Miyazato P, Hahaut V, Yamagishi M, Uchimaru K, Suzuki Y, Ueno T, Suzushima H, Katsuya H, Tokunaga M, Uchiyama Y, Nakamura H, Sueoka E, Utsunomiya A, Ono M, Satou Y. HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma. The Journal of Clinical Investigation 131(24), e150472, 2021.
  • Matsuda K, Islam S, Takada T, Tsuchiya K, Tan B, Hattori S, Katsuya H, Kitagawa K, Kim K,Matsuo M, Sugata K, Delino N, Gatanaga H, Yoshimura K, Matsushita S, Mitsuya H, Iwami S, Satou Y, Maeda K. A widely distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro. Cell Reports Methods 1(8), 100122, 2021.
  • Hiyoshi M, Takahashi N, Eltalkhawy YM, Noyori O, Lotfi S, Panaampon J, Okada S, Tanaka Y, Ueno T, Fujisawa JI, Sato Y, Suzuki T, Hasegawa H, Tokunaga M, Satou Y, Yasunaga JI, Matsuoka M, Utsunomiya A, Suzu S. M-Sec induced by HTLV-1 mediates an efficient viral transmission. PLoS Pathogens 17:e1010126, 2021.
  • Ohnuki N, Kobayashi T, Matsuo M, Nishikaku K, Kusama K, Torii Y, Inagaki Y, Hori M, Imakawa K, Satou Y. A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP. Scientific Reports 11(1), 4521, 2021.
  • Sugata K,Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman M, Anczurowski M, Wang C, Murata K, Saijo H, Kagoya Y, Ly D, Burt B, Butler M, Mak T, Hirano N. Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. Nature Biotechnology doi: 10.1038/s41587-021-00836-4, 2021.

2020年

  • Kalfaoglu B, Almeida-Santos J, Tye CA, Satou Y, Ono M. T-cell dysregulation in COVID-19. Biochemical and Biophysical Research Communications, 538:204-210, doi: 10.1016/j.bbrc.2020.10.079, 2020.
  • Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Mukouyama Y, Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, Baba M, and Kubota Y. Blood and lymphatic systems are segregated by the FLCN tumor suppressor. Nature Communications, 11:6314, 11(1):6314, doi: 10.1038/s41467-020-20156-6, 2020.
  • Kalfaoglu B, Almeida-Santos J, Tye A C, Satou Y, Ono M. T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis. Frontiers in Immunology, 11:589380, doi: 10.3389/fimmu.2020.589380. eCollection 2020, 2020.
    ＊国立研究開発法人日本医療研究開発機構（AMED） プレスリリース
    ＊国立大学法人熊本大学 プレスリリース
  • Aso H, Nagaoka S, Kawakami E, Ito J, Misawa N, Islam S, Tan B, Nakaoka S, Ashizaki K, Shiroguchi K, Suzuki Y, Satou Y, Koyanagi Y, Sato K. Multi-omics investigation revealing comprehensive characteristics of HIV-1-infected cells in vivo. Cell Reports, 32(2):107887, doi: 10.1016/j.celrep.2020.107887, 2020.
過去の発表実績