Nozomi Kuse,* Hayato Murakoshi,* Tomohiro Akahoshi,* Takayuki Chikata, Katherine L James, Hiroyuki Gatanaga, Sarah L Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi (*equal contribution), Collaboration of a detrimental HLA-B*35:01 allele with HLA-A*24:02 in co-evolution of HIV-1 with T-cells leading to poorer clinical outcomes, J. Virol. 95: e01259-21, 2021
Nozomi Kuse, Tomohiro Akahoshi, and Masafumi Takiguchi, STING ligand-mediated priming of functional CD8+ T-cells specific for HIV-1 protective epitopes from naive T-cells, J. Virol. 95: e00699-21, 2021
新型コロナに感染して回復した症例から中和抗体を分離し、ウイルスへの強い結合活性をもった中和抗体が変異株へも有効であることを発表しました。
Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19
Yu Kaku, Takeo Kuwata* Hasan Md Zahid, Takao Hashiguchi, Takeshi Noda, Noriko Kuramoto, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Kazuya Shimura, Chiho Onishi, Yukiko Muramoto, Tateki Suzuki, Jiei Sasaki, Yoji Nagasaki, Rumi Minami, Chihiro Motozono, Mako Toyoda, Hiroshi Takahashi, Hiroto Kishi, Kazuhiko Fujii, Tsuneyuki Tatsuke, Terumasa Ikeda, Yosuke Maeda, Takamasa Ueno, Yoshio Koyanagi, Hajime Iwagoe, and Shuzo Matsushita*
The PhD study by George Judicate et al., has been accepted in Frontiers in Microbiology. The online publication will be coming soon.
ウイルスの感染力を高め、日本人に高頻度な細胞性免疫応答から免れるSARS-CoV-2変異の発見した論文を発表しました。
Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*corresponding authors)
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.
Cell Host and Microbe (2021)
→ Web site (Cell Host and Microbe 2021 )
Yu Zhang, Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Giang Van Tran, Trung Vu Nguyen, Hiroyuki Gatanaga, Kinh Van Nguyen, Shinichi Oka, Nozomi Kuse, and Masafumi Takiguchi, Effect of difference in consensus sequence between HIV-1 subtype A/E and subtype B viruses on elicitation of Gag-specific CD8+ T cells and accumulation of HLA-associated escape mutations, J. Virol. 95: e02061-20, 2021
Joint research about bovine leukemia virus with Tokyo University of Agriculture and Tokai University has been published in Scientific Reports. (Division of Genomics and Transcriptomics)
[A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP]
Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Chengcheng Zou, Mohamed Ali Borghan, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Nozomi Kuse, and Masafumi Takiguchi, Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15:05 on clinical outcome in HIV-1 subtype A/E infection, AIDS 35: 33-43, 2021 (Division of International Collaboration Research / Takiguchi Lab.)
Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J. Brumme, Hayato Murakoshi, Zabrina L. Brumme, Shinichi Oka, and Masafumi Takiguchi, T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics, PLoS Pathog. 16(12): e1009177, 2020
Joint research with Imperial College London was published in Frontiers in Immunology. [T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis]
Copyright @ 2019 Joint Research Center for Human Retrovirus Infection, Kumamoto University