Hayato Murakoshi, Takayuki Chikata, Tomohiro Akahoshi, Chengcheng Zou, Mohamed Ali Borghan, Giang Van Tran, Trung Vu Nguyen, Kinh Van Nguyen, Nozomi Kuse, and Masafumi Takiguchi, Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15:05 on clinical outcome in HIV-1 subtype A/E infection, AIDS 35: 33-43, 2021 (Division of International Collaboration Research / Takiguchi Lab.)
カテゴリー: Publications(JP)
「免疫逃避変異を認識するT細胞による逃避変異集団の構築」に関する論文を発表しました（滝口研、PLoS Pathogens）
Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J. Brumme, Hayato Murakoshi, Zabrina L. Brumme, Shinichi Oka, and Masafumi Takiguchi, T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics, PLoS Pathog. 16(12): e1009177, 2020
英国インペリアル大学との共同研究成果【新型コロナウイルス感染症の重症化に特徴的なT細胞の異常を発見】を論文発表しました。（佐藤研、Frontiers in Immunology）
Joint research with Imperial College London was published in Frontiers in Immunology. [T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis]
逃避変異特異的T細胞によるHIV-1の増殖抑制とHIV-1の共進化に関する論文が、J.Virol.に滝口研から発表されました。
Yu Zhang, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Hayato Murakoshi, and Masafumi Takiguchi, Role of escape mutant-specific T cells in suppression of HIV-1 replication and co-evolution with HIV-1, J. Virol. 94:e01151, 2020 (Division of International Collaboration Research / Takiguchi Lab.)
新型コロナウイルス感染症COVID-19の患者数・死亡者数が何故アジア人が欧米人に比べ少ないのか？Factor Xの候補として、 ACE1 II genotypeを報告 (有海研がGene誌に報告）2020.7.3
Yamamoto N*, Ariumi Y*(*co-first), Nishida Y, Yamamoto R, Bauer G, Gojobori T, Shimotohno K, Mizokami M. SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene Jul 3:144944, 2020 (Division of Retrolelement)
ヒトＴ細胞白血病ウイルスに関する網羅的かつ高精度な新規ウイルス配列情報解析方法を確立（佐藤研がCell Rep誌に発表)
Katsuya, H., Islam, S., Tan, B., Ito, J., Miyazato, P., Matsuo, M., Inada, Y., Iwase, S., Uchiyama, Y., Hata, H., Sato, T., Yagishita, N., Araya, N., Ueno, T., Nosaka, K., Tokunaga, M., Yamagishi, M., Watanabe, T., Uchimaru, K., Fujisawa, J., Utsunomiya, A., Yamano, Y. and Satou, Y. The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach. Cell Reports, 29(3), pp.724-735.e4. , 2019 (Division of Genomics and Transcriptomics)
DNAプローブと次世代シークエンスによる網羅的HIV-1プロウイルス解析法を確立（佐藤研がSci Rep誌に発表)
Iwase SC, Miyazato P, Katsuya H, Islam S, Tan B, Ito J, Matsuo M, Takeuchi H, Ishida T, Matsuda K, Maeda K, and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus. Sci Rep, 9(1):12326, 2019 (Division of Genomics and Transcriptomics)
びまん性大細胞B細胞性リンパ腫におけるIL-34の異所性発現を発見（鈴研がClin Transl Immunology誌に発表)
Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S. Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma. Clinical & Translational Immunology 8 (8): e1074, 2019. (Division of Infection and Hematopoiesis)
タンザニアにおける治療前ＨＩＶ感染者に認める薬剤耐性を発見（上野研がJ Antimicrob Chemother誌に発表）
G Barabona, M Mahiti, S Masoud, P Mbelele, A Shaban Mgunya, L Minja, B Sunguya, U Shigemi, M Matsuda, A Hachiya, Y Iwatani, E Lyamuya, T Ueno. Pre-treatment and acquired HIV drug resistance in Dar es Salaam, Tanzania in the era of tenofovir and routine viral load monitoring. J Antimicrob Chemother https://doi.org/10.1093/jac/dkz272 , 2019 (Division of Infection and Immunity)
HLA-C*12:02を持つ感染者において免疫学的に重要なウイルスエピトープを特定（滝口研がJ. Virol誌に発表）
Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Identification of immunodominant HIV-1 epitopes presented by HLA-C*12:02, a protective allele, using an immunopeptidomics approach, J. Virol, 93(17), e00634-19,2019 (Division of International Collaboration Research / Takiguchi Lab.)
