本園千尋 講師、豊田真子 特任助教、Tan Toong Seng研究員らの新型コロナウイルスオミクロン株に対するT細胞応答に関する研究成果が、Nature Communications誌に公開されました!
プレスリリース:オミクロンBA.1株のG446S変異がワクチン誘導型T細胞の抗ウイルス機能を高めることを発見
本園千尋 講師、豊田真子 特任助教、Tan Toong Seng研究員らの新型コロナウイルスオミクロン株に対するT細胞応答に関する研究成果が、Nature Communications誌に公開されました!
プレスリリース:オミクロンBA.1株のG446S変異がワクチン誘導型T細胞の抗ウイルス機能を高めることを発見
Takayuki Chikata, Wayne Paes, Nozomi Kuse, Thomas Partridge, Hiroyuki Gatanaga, Yu Zhang, Kimiko Kuroki, Katsumi Maenaka, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi, Impact of micropolymorphism outside the peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection, J. Virol. 96: e00432-22, 2022
Daichi Yamasoba#, Izumi Kimura#, Hesham Nasser#, Yuhei Morioka#, Naganori Nao#, Jumpei Ito#, Keiya Uriu#, Masumi Tsuda#, Jiri Zahradnik#, Kotaro Shirakawa, Rigel Suzuki, Mai Kishimoto, Yusuke Kosugi, Kouji Kobiyama, Teppei Hara, Mako Toyoda, Yuri L. Tanaka, Erika P. Butlertanaka, Ryo Shimizu, Hayato Ito, Lei Wang, Yoshitaka Oda, Yasuko Orba, Michihito Sasaki, Kayoko Nagata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Jin Kuramochi, Motoaki Seki, Ryoji Fujiki, Atsushi Kaneda, Tadanaga Shimada, Taka-aki Nakada, Seiichiro Sakao, Takuji Suzuki, Takamasa Ueno, Akifumi Takaori-Kondo, Ken J. Ishii, Gideon Schreiber, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Hirofumi Sawa, Akatsuki Saito*, Takashi Irie*, Shinya Tanaka*, Keita Matsuno*, Takasuke Fukuhara*, Terumasa Ikeda*, Kei Sato*. (#Equal contribution; *Corresponding author)
Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. 2022
DOI: 10.1016/j.cell.2022.04.035
URL: https://www.cell.com/cell/fulltext/S0092-8674(22)00533-5
Benjy Jek Yang Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono and Yorifumi Satou
DOI:10.1172/JCI150472
Nozomi Kuse,* Hayato Murakoshi,* Tomohiro Akahoshi,* Takayuki Chikata, Katherine L James, Hiroyuki Gatanaga, Sarah L Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi (*equal contribution), Collaboration of a detrimental HLA-B*35:01 allele with HLA-A*24:02 in co-evolution of HIV-1 with T-cells leading to poorer clinical outcomes, J. Virol. 95: e01259-21, 2021
Nozomi Kuse, Tomohiro Akahoshi, and Masafumi Takiguchi, STING ligand-mediated priming of functional CD8+ T-cells specific for HIV-1 protective epitopes from naive T-cells, J. Virol. 95: e00699-21, 2021
新型コロナに感染して回復した症例から中和抗体を分離し、ウイルスへの強い結合活性をもった中和抗体が変異株へも有効であることを発表しました。
Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19
Yu Kaku, Takeo Kuwata* Hasan Md Zahid, Takao Hashiguchi, Takeshi Noda, Noriko Kuramoto, Shashwata Biswas, Kaho Matsumoto, Mikiko Shimizu, Yoko Kawanami, Kazuya Shimura, Chiho Onishi, Yukiko Muramoto, Tateki Suzuki, Jiei Sasaki, Yoji Nagasaki, Rumi Minami, Chihiro Motozono, Mako Toyoda, Hiroshi Takahashi, Hiroto Kishi, Kazuhiko Fujii, Tsuneyuki Tatsuke, Terumasa Ikeda, Yosuke Maeda, Takamasa Ueno, Yoshio Koyanagi, Hajime Iwagoe, and Shuzo Matsushita*
ウイルスの感染力を高め、日本人に高頻度な細胞性免疫応答から免れるSARS-CoV-2変異の発見した論文を発表しました。
Motozono, C., Toyoda, M., Zahradnik, J., Saito, A., Nasser, H., Tan, T.S., Ngare, I., Kimura, I., Uriu, K., Kosugi, Y., Yue, Y., Shimizu, R., Ito, J., Torii, S., Yonekawa, A., Shimono, N., Nagasaki, Y., Minami, R., Toya, T., Sekiya, N., Fukuhara, T., Matsuura, Y., Schreiber, G., The Genotype to Phenotype Japan (G2P-Japan) Consortium, *Ikeda, T., *Nakagawa, S., *Ueno, T., *Sato, K. (*corresponding authors)
SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity.
Cell Host and Microbe (2021)
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